https://revistas.udea.edu.co/index.php/hm/issue/feed 2025-11-05T17:51:29-05:00 Ángel González Marín revistahechosmicrobiologicos@udea.edu.co Open Journal Systems <ul> <li class="show"><strong>ISSN Print:</strong> 2145-8898</li> <li class="show"><strong>On line ISSN:</strong> 2805-6485</li> <li class="show"><strong>Periodicity:</strong> Semestral</li> <li class="show"><strong>Creative Commons:</strong>&nbsp;<a href="https://creativecommons.org/licenses/by-nc-sa/2.5/co/" target="_blank" rel="noopener">by-nc-sa</a></li> </ul> https://revistas.udea.edu.co/index.php/hm/article/view/362037 2025-09-19T16:11:19-05:00 Carlos Quesada-Gómez carlos.quesada@ucr.ac.cr Fabiola Rodriguez-Mena fabiola.rodriguez@ucr.ac.cr

<p><strong>Background:</strong> The genera <em>Clostridium, Paraclostridium</em>, and <em>Paeniclostridium</em> comprise Gram-positive, spore-forming, anaerobic bacteria widely distributed in the environment and human microbiota. Their ability to produce a broad range of toxins and their frequent exposure to antimicrobials confer high clinical relevance in diverse infections. <strong>Objective:</strong> To analyze resistance profiles to 11 antimicrobials in clinical isolates of these genera. <strong>Methods:</strong> A search and review of articles published in the period 2015-2020 in PubMed was carried out. <strong>Results</strong>: The highest resistance was observed against moxifloxacin, while tigecycline showed the lowest. Isolates with the highest resistance levels were mainly derived from traumatic wounds and bacteremia. A consistent finding was the comparatively lower resistance of <em>C. perfringens</em> compared to other species. Conversely, a <em>C. innocuum</em> strain exhibited a multidrug-resistant profile, with resistance to penicillin, clindamycin, and amoxicillin-clavulanic acid, in addition to its intrinsic resistance to vancomycin.<strong> Conclusion:</strong> These findings highlight the importance of active and continuous surveillance of antimicrobial resistance profiles in anaerobic bacteria, especially since such analyses are not routinely performed in clinical laboratories.</p>

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