Nefritis tubulointersticial aguda. Revisión bibliográfica

Palabras clave: Enfermedades Renales, Insuficiencia Renal, Lesión Renal Aguda, Nefritis Tubulointersticial

Resumen

La nefritis tubulointersticial aguda hace referencia a un tipo de daño renal que afecta principalmente el intersticio y ocasiona la lesión renal aguda, potencialmente reversible. Su curso puede ser subclínico, con deterioro progresivo hasta evolucionar hacia la insuficiencia renal crónica. La nefritis tubulointersticial aguda tiene múltiples etiologías, las más frecuentes son los medicamentos, productos herbales, las infecciones y las enfermedades autoinmunes.

Las principales manifestaciones clínicas son la poliuria, polaquiuria, nocturia, dolor lumbar, microhematuria y leucocituria, aunque puede ser totalmente asintomática. El tratamiento depende de la causa de base y los esteroides juegan un papel importante cuando la condición es de origen medicamentoso o autoinmune. El pronóstico generalmente es bueno, si el problema se identifica de forma oportuna y se trata adecuadamente.

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Biografía del autor/a

John Fredy Nieto-Ríos, Universidad de Antioquia

Médico Internista, Nefrólogo

Luis Miguel Ruiz-Velásquez, Universidad Pontificia Bolivariana

Médico Residente de Medicina Interna

Laura Álvarez, Fundación Universitaria San Martín

Médico General

Lina Maria Serna-Higuita, Eberhard Karls University, Institute for Clinical Epidemiology und Applied Biometrics
Estudiante de doctorado, Departamento de Epidemiología clínica y Biometría

Citas

(1.) Surendra M, Raju S, Chandragiri S, Uppin MS, Raju N. Steroid therapy in drug induced acute interstitial nephritis-Retrospective analysis of 83 cases. Saudi J Kidney Dis Transpl. 2019;30(1):157-65. DOI 10.4103/1319-2442.252906.

(2.) Ulinski T, Sellier-Leclerc AL, Tudorache E, Bensman A, Aoun B. Acute tubulointerstitial nephritis. Pediatr Nephrol. 2012;27(7):1051-7. DOI 10.1007/s00467-011-1915-9.

(3.) Kizilbash Q. Successful management of acute interstitial nephritis in two cases of disseminated tuberculosis. Tuberculosis (Edinb). 2016;101S:S135-S6. DOI 10.1016/j.tube.2016.09.014.

(4.) Johnson R, Feehally J, Floege J, Tonelli M. Comprehensive Clinical Nephrology. 6ed. EE. UU: Elsevier; 2019. 1360 p.

(5.) Skorecki K, Chertow G, Marsden P, Taal M, You A. Brenner y Rector. El riñón. 10 ed. España: Elsevier; 2018.

(6.) Praga M, Gonzalez E. Acute interstitial nephritis. Kidney Int. 2010;77(11):956-61. DOI 10.1038/ki.2010.89.

(7.) Cameron JS. Allergic interstitial nephritis: clinical features and pathogenesis. Q J Med. 1988;66(250):97-115.

(8.) Pettersson E, von Bonsdorff M, Tornroth T, Lindholm H. Nephritis among young Finnish men. Clin Nephrol. 1984;22(5):217-22.

(9.) Eddy AA. Drug-induced tubulointerstitial nephritis: hypersensitivity and necroinflammatory pathways. Pediatr Nephrol. 2019. DOI 10.1007/s00467-019-04207-9.

(10.) Haas M, Spargo BH, Wit EJ, Meehan SM. Etiologies and outcome of acute renal insufficiency in older adults: a renal biopsy study of 259 cases. Am J Kidney Dis. 2000;35(3):433-47. DOI 10.1016/S0272-6386(00)70196-X.

(11.) Farrington K, Levison DA, Greenwood RN, Cattell WR, Baker LR. Renal biopsy in patients with unexplained renal impairment and normal kidney size. Q J Med. 1989;70(263):221-33.

(12.) Praga M, Sevillano A, Aunon P, Gonzalez E. Changes in the aetiology, clinical presentation and management of acute interstitial nephritis, an increasingly common cause of acute kidney injury. Nephrol Dial Transplant. 2015;30(9):1472-9. DOI 10.1093/ndt/gfu326.

(13.) Muriithi AK, Leung N, Valeri AM, Cornell LD, Sethi S, Fidler ME, et al. Clinical characteristics, causes and outcomes of acute interstitial nephritis in the elderly. Kidney Int. 2015;87(2):458-64. DOI 10.1038/ki.2014.294.

(14.) Davison AM, Jones CH. Acute interstitial nephritis in the elderly: a report from the UK MRC Glomerulonephritis Register and a review of the literature. Nephrol Dial Transplant. 1998;13 Suppl 7:12-6. DOI 10.1093/ndt/13.suppl_7.12.

(15.) Lamy PP. Renal effects of nonsteroidal antiinflammatory drugs. Heightened risk to the elderly? J Am Geriatr Soc. 1986;34(5):361-7. DOI 10.1111/j.1532-5415.1986.tb04319.x.

(16.) Wilson GJ, Kark AL, Francis LP, Hoy W, Healy HG, Mallett AJ. The increasing rates of acute interstitial nephritis in Australia: a single centre case series. BMC Nephrol. 2017;18(1):329. DOI 10.1186/s12882-017-0747-7.

(17.) Reddy S, Salant DJ. Treatment of acute interstitial nephritis. Ren Fail. 1998;20(6):829-38. DOI 10.3109/08860229809045180.

(18.) Schwarz A, Krause PH, Kunzendorf U, Keller F, Distler A. The outcome of acute interstitial nephritis: risk factors for the transition from acute to chronic interstitial nephritis. Clin Nephrol. 2000;54(3):179-90.

(19.) Baker RJ, Pusey CD. The changing profile of acute tubulointerstitial nephritis. Nephrol Dial Transplant. 2004;19(1):8-11.

DOI 10.1093/ndt/gfg464.

(20.) Arias LF. Nefropatología [Internet]. [Cited 2018 July 12]. Disponible en: https://cutt.ly/JePPH6p

(21.) Fogo A, Kashgarian M. Diagnostic Atlas of Renal Pathology. 3 ed. Reino Unido: Elsevier; 2016.

(22.) Raghavan R, Eknoyan G. Acute interstitial nephritis - a reappraisal and update. Clin Nephrol. 2014;82(3):149-62. DOI 10.5414/CN10838.

(23.) Lucas GNC, Leitao ACC, Alencar RL, Xavier RMF, Daher EF, Silva Junior GBD. Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs. J Bras Nefrol. 2019;41(1):124-30. DOI 10.1590/2175-8239-jbn-2018-0107.

(24.) Perazella MA, Markowitz GS. Drug-induced acute interstitial nephritis. Nat Rev Nephrol. 2010;6(8):461-70. DOI 10.1038/nrneph.2010.71.

(25.) Nast CC. Medication-Induced Interstitial Nephritis in the 21st Century. Adv Chronic Kidney Dis. 2017;24(2):72-9. DOI 10.1053/j.ackd.2016.11.016.

(26.) Rho M, Perazella MA. Nephrotoxicity associated with antiretroviral therapy in HIV-infected patients. Curr Drug Saf. 2007;2(2):147-54. DOI 10.2174/157488607780598269.

(27.) Simpson IJ, Marshall MR, Pilmore H, Manley P, Williams L, Thein H, et al. Proton pump inhibitors and acute interstitial nephritis: report and analysis of 15 cases. Nephrology (Carlton, Vic). 2006;11(5):381-5. DOI 10.1111/j.1440-1797.2006.00651.x.

(28.) Sierra F, Suarez M, Rey M, Vela MF. Systematic review: Proton pump inhibitor-associated acute interstitial nephritis. Aliment Pharmacol Ther. 2007;26(4):545-53. DOI 10.1111/j.1365-2036.2007.03407.x.

(29.) Ambruzs JM, Walker PD, Larsen CP. The histopathologic spectrum of kidney biopsies in patients with inflammatory bowel disease. Clin J Am Soc Nephrol. 2014;9(2):265-70. DOI 10.2215/CJN.04660513.

(30.) Gisbert JP, Gonzalez-Lama Y, Mate J. 5-Aminosalicylates and renal function in inflammatory bowel disease: a systematic review. Inflamm Bowel Dis. 2007;13(5):629-38. DOI 10.1002/ibd.20099.

(31.) Vasanth P, Parmley M, Torrealba J, Hamdi T. Interstitial Nephritis in a Patient with Inflammatory Bowel Disease. Case Rep Nephrol. 2016. DOI 10.1155/2016/4260365.

(32.) Chaponda M, Pirmohamed M. Hypersensitivity reactions to HIV therapy. Br J Clin Pharmacol. 2011;71(5):659-71. DOI 10.1111/j.1365-2125.2010.03784.x.

(33.) Effa EE, Ekrikpo UE, Borkum M, Rayner BL, Heering P, Okpechi IG. Clinical profile and outcome of patients with biopsy-proven acute interstitial nephritis in Cape Town: a 10-year review. Clin Nephrol. 2017;88(8):97-104. DOI 10.5414/CN109163.

(34.) Lanot A, Bouvier N, Chatelet V, Dina J, Bechade C, Ficheux M, et al. [BK virus infections in kidney transplantation]. Nephrol Ther. 2016;12(2):76-85. DOI 10.1016/j.nephro.2015.11.003.

(35.) Maripuri S, Grande JP, Osborn TG, Fervenza FC, Matteson EL, Donadio JV, et al. Renal involvement in primary Sjogren's syndrome: a clinicopathologic study. Clin J Am Soc Nephrol. 2009;4(9):1423-31. DOI 10.2215/CJN.00980209.

(36.) Serna Higuita LM, Londono J, Velez-Echeverri C, Serrano AK, Ochoa-Garcia C, Rojas Rosas L, et al. Síndrome de nefritis túbulo-intersticial y uveítis en una paciente pediátrica. NefroPlus. 2015;7(1):72-5. DOI 10.3265/NefroPlus.pre2015.Feb.12529.

(37.) Krishnan N, Perazella MA. Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment. Iran J Kidney Dis. 2015;9(1):3-13.

(38.) Moledina DG, Perazella MA. Drug-Induced Acute Interstitial Nephritis. Clin J Am Soc Nephrol. 2017;12(12):2046-9. DOI 10.2215/CJN.07630717.

(39.) Yao YH, Lin CC, Chung YM, Yang AH, Li SY, Lin CC, et al. Tubulointerstitial nephritis and uveitis syndrome (TINU) with Fanconi's syndrome. Clin Nephrol. 2011;75 Suppl 1:75-8. DOI 10.5414/CN106471.

(40.) Karras DJ. Severe low back pain secondary to acute interstitial nephritis following administration of ranitidine. Am J Emerg Med. 1994;12(1):67-8. DOI 10.1016/0735-6757(94)90203-8.

(41.) Strutz F, Grupp C. [Tubulointerstitial Nephritis (Drug-Induced, Inflammatory)]. Dtsch Med Wochenschr. 2018;143(11):802-5. DOI 10.1055/a-0511-8458.

(42.) Rosen S, Stillman IE. Acute tubular necrosis is a syndrome of physiologic and pathologic dissociation. J Am Soc Nephrol. 2008;19(5):871-5. DOI 10.1681/ASN.2007080913.

(43.) Chawla LS, Kellum JA. Acute kidney injury in 2011: Biomarkers are transforming our understanding of AKI. Nat Rev Nephrol. 2012;8(2):68-70. DOI 10.1038/nrneph.2011.216.

(44.) Brodsky S, Nadasdy T. En: Charles J, Vivette D, D'Agati, Jean L. Olson, Silva FG. Heptinstall's Pathology of the Kidney. 7 Ed. Toronto: Wolters Kluwer; 2015. p. 1111-65.

(45.) Chowdry AM, Azad H, Mir I, Najar MS, Ashraf BM, Muzafar WM, et al. Drug-induced acute interstitial nephritis: Prospective randomized trial comparing oral steroids and high-dose intravenous pulse steroid therapy in guiding the treatment of this condition. Saudi J Kidney Dis Transpl. 2018;29(3):598-607. DOI 10.4103/1319-2442.235171.

(46.) Clarkson MR, Giblin L, O'Connell FP, O'Kelly P, Walshe JJ, Conlon P, et al. Acute interstitial nephritis: clinical features and response to corticosteroid therapy. Nephrol Dial Transplant. 2004;19(11):2778-83. DOI 10.1093/ndt/gfh485.

(47.) González E, Gutiérrez E, Galeano C, Chevia C, de Sequera P, Bernis C, et al. Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis. Kidney Int. 2008;73(8):940-6. DOI 10.1038/sj.ki.5002776.

(48.) Raza MN, Hadid M, Keen CE, Bingham C, Salmon AH. Acute tubulointerstitial nephritis, treatment with steroid and impact on renal outcomes. Nephrology (Carlton, Vic). 2012;17(8):748-53. DOI 10.1111/j.1440-1797.2012.01648.x.

(49.) Prendecki M, Tanna A, Salama AD, Tam FW, Cairns T, Taube D, et al. Long-term outcome in biopsy-proven acute interstitial nephritis treated with steroids. Clin Kidney J. 2017;10(2):233-9. DOI 10.1093/ckj/sfw116.

(50.) Valluri A, Hetherington L, McQuarrie E, Fleming S, Kipgen D, Geddes CC, et al. Acute tubulointerstitial nephritis in Scotland. QJM. 2015;108(7):527-32. DOI 10.1093/qjmed/hcu236.

(51.) Rossert J. Drug-induced acute interstitial nephritis. Kidney Int. 2001;60(2):804-17. DOI 10.1046/j.1523-1755.2001.060002804.x.

(52.) Clive DM, Stoff JS. Renal syndromes associated with nonsteroidal antiinflammatory drugs. N Engl J Med. 1984;310(9):563-72. DOI 10.1056/NEJM198403013100905.

(53.) Fernández-Juárez G, Pérez JV, Caravaca-Fontan F, Quintana L, Shabaka A, Rodriguez E, et al. Duration of Treatment with Corticosteroids and Recovery of Kidney Function in Acute Interstitial Nephritis. Clin J Am Soc Nephrol. 2018;13(12):1851-8. DOI 10.2215/CJN.01390118.

(54.) Moledina DG, Perazella MA. Treatment of Drug-Induced Acute Tubulointerstitial Nephritis: The Search for Better Evidence. Clin J Am Soc Nephrol. 2018;13(12):1785-7. DOI 10.2215/CJN.12001018.

(55.) Porile JL, Bakris GL, Garella S. Acute interstitial nephritis with glomerulopathy due to nonsteroidal anti-inflammatory agents: a review of its clinical spectrum and effects of steroid therapy. J Clin Pharmacol. 1990;30(5):468-75. DOI 10.1002/j.1552-4604.1990.tb03487.x.

(56.) Woodruff AE, Meaney CJ, Hansen EA, Prescott GM. Azithromycin-Induced, Biopsy-Proven Acute Interstitial Nephritis in an Adult Successfully Treated with Low-Dose Corticosteroids. Pharmacotherapy. 2015;35(11):e169-74. DOI 10.1002/phar.1660.

(57.) Preddie DC, Markowitz GS, Radhakrishnan J, Nickolas TL, D'Agati VD, Schwimmer JA, et al. Mycophenolate mofetil for the treatment of interstitial nephritis. Clin J Am Soc Nephrol. 2006;1(4):718-22. DOI 10.2215/CJN.01711105.

(58.) Zuliani E, Zwahlen H, Gilliet F, Marone C. Vancomycin-induced hypersensitivity reaction with acute renal failure: resolution following cyclosporine treatment. Clin Nephrol. 2005;64(2):155-8. DOI 10.5414/CNP64155.

(59.) Galpin JE, Shinaberger JH, Stanley TM, Blumenkrantz MJ, Bayer AS, Friedman GS, et al. Acute interstitial nephritis due to methicillin. Am J Med. 1978;65(5):756-65. DOI 10.1016/0002-9343(78)90793-3.

(60.) Laberke HG, Bohle A. Acute interstitial nephritis: correlations between clinical and morphological findings. Clin Nephrol. 1980;14(6):263-73.

Publicado
2020-04-01
Cómo citar
Nieto-Ríos, J. F., Ruiz-Velásquez, L. M., Álvarez, L., & Serna-Higuita, L. M. (2020). Nefritis tubulointersticial aguda. Revisión bibliográfica. Iatreia, 33(2), 155-166. https://doi.org/10.17533/udea.iatreia.45
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Artículos de revisión