Compromiso neurológico en chikungunya: un meta-análisis de su prevalencia

  • Alfonso J. Rodríguez Morales Universidad Tecnológica de Pereira, Fundación Cenit Colombia, Asociación Colombiana de Infectología, Organización Latinoamericana para el Fomento de la Investigación en Salud
  • Diana M. Castañeda Hernández Universidad Tecnológica de Pereira, Fundación Cenit Colombia, Fundación Universitaria del Área Andina
  • Andrea G. Rodríguez Morales Clínica Sanitas
Palabras clave: virus chikungunya, encefalitis, convulsiones, América Latina, metanálisis, epidemiología

Resumen

Objetivo: Determinar la proporción de pacientes que desarrollan manifestaciones  y/o  complicaciones  neurológicas  de  la infección por chikungunya (NeuroCHIK)

Métodos: Se llevó a cabo una revisión sistemática de la literatura en tres bases de datos (PubMed, SCI y Scopus) con el fin de identificar estudios que evaluaran la proporción de pacientes que presentan NeuroCHIK. Se realizó un modelo de meta-análisis de efectos aleatorios para calcular  la  prevalencia  combinada  y  su  IC95%.  Se  estimaron  y  reportaron  medidas  de  heterogeneidad,  incluyendo  el  estadístico  Q  de  Cochrane,  el  índice  I2  y  la  prueba  de  tau  cuadrado.  Se  hicieron  análisis  de  subgrupos  por  tipos  de  estudios,  países,  estudios  con ≥200 pacientes, estudios evaluando dificultades de  atención,  encefalitis  y  convulsiones.  El  sesgo  de  publicación se evaluó usando un funnel-plot.

Conclusión: De acuerdo a los resultados, en el escenario más conservador, cerca de  33% de casos  cHiK Desarrollarían neurocHiK (36% si consideramos solo los estudios prospectivos),  10% en cefalitis y 3% convulsiones.

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Biografía del autor/a

Alfonso J. Rodríguez Morales, Universidad Tecnológica de Pereira, Fundación Cenit Colombia, Asociación Colombiana de Infectología, Organización Latinoamericana para el Fomento de la Investigación en Salud
Grupo de Investigación Salud Pública e Infecciones, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira, Risaralda, Colombia. Fundación Cenit Colombia, Pereira, Risaralda, Colombia. Comité de Zoonosis y Fiebres Hemorrágicas, Asociación Colombiana de Infectología, Bogotá, DC, Colombia. Organización Latinoamericana para el Fomento de la Investigación en Salud (OLFIS), Bucaramanga, Santander, Colombia.
Diana M. Castañeda Hernández, Universidad Tecnológica de Pereira, Fundación Cenit Colombia, Fundación Universitaria del Área Andina

Grupo de Investigación Salud Pública e Infecciones, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira, Risaralda, Colombia. Fundación Cenit Colombia, Pereira, Risaralda, Colombia. Fundación Universitaria del Área Andina, Pereira, Risaralda, Colombia.

Andrea G. Rodríguez Morales, Clínica Sanitas

Clínica Sanitas, Caracas, DC, Venezuela.

Citas

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Publicado
2016-06-21
Cómo citar
Rodríguez Morales A. J., Castañeda Hernández D. M., & Rodríguez Morales A. G. (2016). Compromiso neurológico en chikungunya: un meta-análisis de su prevalencia. Hechos Microbiológicos, 5(2), 77-91. Recuperado a partir de https://revistas.udea.edu.co/index.php/hm/article/view/323253
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Artículos de investigación original