Compromiso neurológico en chikungunya: un meta-análisis de su prevalencia
DOI:
https://doi.org/10.17533/udea.hm.323253Palabras clave:
virus chikungunya, encefalitis, convulsiones, América Latina, metanálisis, epidemiologíaResumen
Objetivo: Determinar la proporción de pacientes que desarrollan manifestaciones y/o complicaciones neurológicas de la infección por chikungunya (NeuroCHIK)
Métodos: Se llevó a cabo una revisión sistemática de la literatura en tres bases de datos (PubMed, SCI y Scopus) con el fin de identificar estudios que evaluaran la proporción de pacientes que presentan NeuroCHIK. Se realizó un modelo de meta-análisis de efectos aleatorios para calcular la prevalencia combinada y su IC95%. Se estimaron y reportaron medidas de heterogeneidad, incluyendo el estadístico Q de Cochrane, el índice I2 y la prueba de tau cuadrado. Se hicieron análisis de subgrupos por tipos de estudios, países, estudios con ≥200 pacientes, estudios evaluando dificultades de atención, encefalitis y convulsiones. El sesgo de publicación se evaluó usando un funnel-plot.
Conclusión: De acuerdo a los resultados, en el escenario más conservador, cerca de 33% de casos cHiK Desarrollarían neurocHiK (36% si consideramos solo los estudios prospectivos), 10% en cefalitis y 3% convulsiones.
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