Perfil hematológico de los trabajadores de la minería del oro expuestos a vapores de mercurio metálico en el municipio de Amalfi, Antioquia

Paola A.  Acevedo Toro; Natalia M.  Guevara Arismendy; Adriana M.  Rodríguez Acevedo

doi:10.17533/udea.hm.5222

Authors

Paola A. Acevedo Toro University of Antioquia
Natalia M. Guevara Arismendy University of Antioquia
Adriana M. Rodríguez Acevedo University of Antioquia

DOI:

https://doi.org/10.17533/udea.hm.5222

Keywords:

chronic exposure, complete blood count, Hemoglobin, mercury vapours, mining, peripheral blood smear

Abstract

Introduction

The complete blood count (hemoleucogram) is a test that provides information on the health status of an individual, and may be altered in gold mining workers who are chronically exposed to metallic mercury vapors.

Objective

To determine the hematologic profile in gold mining workers from Amalfi, Antioquia, chronically exposed to metallic mercury vapours.

Materials and methods

This study included 41 miners and seven workers from the gold trading industry exposed to metallic mercury vapors (paired with 48 unexposed subjects in accordance with individual characteristics). A complete blood count was done for each participant, as well as a peripheral blood smear and mercury detection in urine after 24 hours.

Results

Gold mining workers had a mean concentration of 59.7 μg/L of mercury in their urine, and were found to have multiple qualitative (morphological) and quantitative abnormalities in their complete blood count. Of these abnormalities, the values of hemoglobin, mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC), showed a statistically significant difference between the groups of exposed and unexposed individuals (p<0.05).

Conclusions

There is a possible relationship between exposure to metallic mercury vapors and alterations in the differential white blood cell count, hemoglobin and red blood cell indices; however, additional studies are needed to confirm the effect of this metal on hematopoietic homeostasis.

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Author Biographies

Paola A. Acevedo Toro , University of Antioquia

Microbiologist and Bioanalyst. Master in Basic Biomedical Sciences. Professor, School of Microbiology, University of Antioquia, Colombia.

Natalia M. Guevara Arismendy, University of Antioquia

Student of Microbiology and Bioanalysis. Teaching Assistant, School of Microbiology, University of Antioquia, Colombia.

Adriana M. Rodríguez Acevedo, University of Antioquia

Student of Microbiology and Bioanalysis, School of Microbiology, University of Antioquia, Colombia.

References

Municipio de Amalfi. Alcaldía local acceso 27 de Junio 2009. Disponible en: http://www.amalfi-antioquia.gov.co/ 2.

Instituto Colombiano de Geología y Minería – INGEO-MINAS. Dirección de Servicio Minero. Subdirección de Fiscalización y Ordenamiento Minero. Grupo de Re-caudo y Distribución de Regalías. Informe Detallado Producción de Metales Preciosos. I y II Trimestre Año 2009 (en gramos); 2009.

Montenegro R. Estudio sobre el impacto ambiental y sanitario de las minas de oro, caso Cordón Esquel. Universidad Nacional de Córdoba Argentina; 2003.

Marín D. Intoxicación profesional por mercurio Tesis. Medellín: Universidad de Antioquia; 2004.

Fagala G, Wigg C. Psychiatric manifestations of mercury poisoning. J Am Acad Child Adolesc Psychiatry. 1992; 31: 306-11.

Fourtes L, Weismann D, Graeff M, Bale J, Tannous R, Peters C. Immune Thrombocytopenia and Elemental Mercury Poisoning. J Toxicol Clin Toxicol. 1995; 33: 449-55.

Lanskowsky P. Manual of pediatric hematology and oncology. 4th ed. Burlington: Elsevier; 2005.

Maramba N, Reyes J, Francisco-Rivera A, Panganiban L, Dioquino C, Dando N, et al. Environmental and human exposure assessment Monitoring of communities near an abandoned mercury mine in the Philippines: A toxic legacy. J Environ Manag. 2006; 81: 135-45.

Rowens B, Guerrero-Betancourt D, Gottlieb C, et al.Respiratory failure and death following acute inhalation of mercury vapor: A clinical and histologic perspective. Chest. 1991; 99: 185-90.

Schumacher H, Rock W, Stass S. Handbook of Hematologic Pathology. New York: Marcel Dekker Inc; 2000.

Schwartz J, Snider T, Montiel M. Toxicity of a family from vacuumed mercury. Am J Emerg Med. 1992; 10: 258-61.

Siblerud RL. The relationship between mercury from dental amalgam and the cardiovascular system. Sci Total Environ. 1990; 99: 23-36.

Zabinzki Z, Rutowski J, Moszczynski P, Dabrowski Z.Red cell system and selected red cell enzymes in men occupationally exposed to mercuric vapours. Przeql Lek. 2006; 63 Supl 7: 74-83.

Ercal N, Gurer-Orhan H, Aykin-Burns N. Toxic metals and oxidative stress, Part I: mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem. 2001; 1: 529-39.

Özdabak HN, Karaoğlanğlu S, Akgül N, Polat F, Seven N. The effects of amalgam restorations on plasma mercury levels and total antioxidant activity. Arch Oral Biol. 2008; 53: 1101-6.

Kobal AB, Horvat M, Prezelj M, Briški AS, Krsnik M, Dizdarevič T, et al. The impact of long term past expo-sure to elemental mercury on antioxidative capacity and lipid peroxidation in mercury miners. J Trace Elem Med Biol. 2004; 17: 261-74.

World Health Organization. Inorganic mercury. In ‘‘Environmental Health Criteria 118’’. World Health Organization. Geneva: WHO; 1991.

Nordberg G, Brune D, Gerhardsson L, Grandjean P, Vesterberg O, Wester P. The ICOH and IUPAC international programme for establishing reference values of metals. Sci Total Environ. 1992; 120: 17-21.

American Conference of Industrial Hygienists. Threshold limit values for chemical substances and physical Agents & biological exposures indices. Cincinnati: AC-GIH; 2005.

Berrío M, Correa M, Jiménez M. El hemograma: análisis e interpretación con las tres generaciones. Medellín: Editorial Universidad de Antioquia; 2003.

Leclair S. Alteraciones cuantitativas de los leucocitos. En: Rodak B. Hematología. Fundamentos y Aplicaciones Clínicas. 2a ed. Argentina: Editorial Médica Panamericana; 2004.

Sullivan K, Mei Z, Grummer-Strawn L, Parvanta I. Haemoglobin adjustments to define anaemia. Trop Med Int Health. 2008; 13: 1267-71.

Method 7473. Mercury in solids and solutions by thermal decomposition, amalgamation, and atomic absorption spectrophotometry acceso 20 de febrero de 2009. En: Environmental Protection Agency. 1998. Available from: http://www.epa.gov/osw//hazard/testmethods/sw846/pdfs/7473.pdf/24. Boylan H, Walter P, Kingston H. “Direct Mercury Analy-sis: Field and Laboratory Validation for EPA Method 7473”; 1997.25. Glass G, Sorenson J, Schmidt K, Rapp G, Yap D, Fra-ser D. Mercury deposition and sources for the upper Great-Lakes region. Water Air Soil Pollut. 1991; 56: 235-49.

World Health Organization. Concise International Chemical Assessment Document, No 50. Elemental mercury and inorganic mercury compounds human health aspects.. Geneva: WHO; 2003.

Vimercati L, Santarelli L, Pesola G, Drago I, Lasorsa G, Valentino M, et al. Monocyte-macrophage system and polymorphonuclear leukocytes in workers exposed to low levels of metallic Mercury. Sci Total Environ. 2001; 270: 157-63.

Bain BJ. Blood Cells. A Practical Guide. 4th ed. Malden Massachussets: Blackwell Sinergy; 2006.

Tkachuk DC, Hirschmann JV. Wintrobe’s Atlas of Clinical Hematology. Philadelphia: Lippincott Williams and Wilkins; 2007.

Giralt M. Neutropenias y agranulocitosis. En: SansSabrafen J, Besses C, Vives J. Hematología Clínica. 4a ed. Madrid: Harcourt; 2001.

Sweet L, Passino-Reader D, Meier P, Omann G. Effects of polychlorinated biphenyls, hexachlorocyclohexanes, and mercury on human neutrophil apoptosis, actin cytoskelton, and oxidative state. Environ Toxicol Pharmacol. 2006; 22: 179-88.

Contrino J, Marucha P, Ribaudo R, Ference R, Bigazzi P, Kreutzer D. Effects of mercury on human polymorphonuclear leukocyte function in vitro. Am J Pathol. 1988; 132: 110-8.

Obel N, Hansen B, Christensen M, Nielsen S, Rungby J.Methyl mercury, mercuric chloride, and silver lactate decrease superoxide anion formation and chemotaxis in human polymorphonuclear leucocytes. Hum Exp Toxicol. 1993; 12: 361-4.

Shenker B, Berthold P, Decker S, Mayro J, Rooney C, Vitale L, Shapiro I. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. II. Alterations in cell viability. Immunopharmacol Immunotoxicol. 1992; 14: 555-77.

Shenker B, Berthold P, Rooney C, Vitale L, DeBolt K, Shapiro I. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. III. Alterations in B-cell function and viability. Immunopharmacol Immu-notoxicol. 1993; 15: 87-112.

Shenker B, Guo T, Shapiro I. Low-Level Methylmercury Exposure Causes Human T-Cells to Undergo Apoptosis: Evidence of Mitochondrial Dysfunction. Environ Res. 1998; 77: 149-59.37. Leclair S. Alteraciones cualitativas de los leucocitos. En: Rodak B. Hematología. Fundamentos y Aplicacio-nes Clínicas. 2a ed. Argentina: Editorial Médica Pana-mericana; 2004.

Leclair S. Alteraciones cualitativas de los leucocitos. En: Rodak B. Hematología. Fundamentos y Aplicaciones Clínicas. 2a ed. Argentina: Editorial Médica Panamericana; 2004.