Principales características de la genética bacteriana de Pseudomonas aeruginosa que contribuyen con su patogénesis y resistencia

Johanna Marcela Vanegas M.; Judy Natalia Jiménez Q.

doi:10.17533/udea.hm.21091

Authors

Johanna Marcela Vanegas M. University of Antioquia
Judy Natalia Jiménez Q. University of Antioquia

DOI:

https://doi.org/10.17533/udea.hm.21091

Keywords:

bacteria genetics, accesory genome, core genome, Pseudomonas aeruginosa, antimicrobial resistance, pathogenesis

Abstract

Pseudomonas aeruginosa has emerged as an important pathogen in the hospital environment due to its role in the origin of diverse clinical conditions and its development of antibiotic resistance. Advances in molecular biology have enabled genome knowledge of this microorganism and elucidated the components that contribute to its pathogenesis and resistance.

Objective: Describe the main features of core and accessory ge-nomes of P. aeruginosa that promote its pathogenesis and resistance.

Methodology: Narrative review.

Development: Genome of P. aeruginosa shows its ability to adapt to different hosts and environments in nature. While the core genome is conserved, the accessory geno-me is highly variable and is composed of genetic elements as plasmids, transposons and integrons, which do not possess virulence genes only, but also antibiotic resistance genes.

Conclusions: Pathogenesis and resistance of P. aeruginosa are me-diated by diverse genes both constitutive and acquired that promote its persistence in nature and human hosts.

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Author Biographies

Johanna Marcela Vanegas M. , University of Antioquia

Bacterial Molecular Epidemiology Line, Molecular Microbiology Group, Basic and Applied Microbiology Group (MICROBA), School of Microbiology, University of Antioquia.

Judy Natalia Jiménez Q. , University of Antioquia

Bacterial Molecular Epidemiology Line, Molecular Microbiology Group, Basic and Applied Microbiology Group (MICROBA), School of Microbiology, University of Antioquia.

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