Efecto inmunodulador y microbicida de las células mesenquimales estromales obtenidas de médula ósea

Julián Camilo  Arango Rincón

doi:10.17533/udea.hm.v11n1a05

Authors

Julián Camilo Arango Rincón University of Antioquia https://orcid.org/0000-0001-5094-8260

DOI:

https://doi.org/10.17533/udea.hm.v11n1a05

Keywords:

mesenchymal stromal cells, mesenchymal stem cells, immunomodulation, microbicidal effect

Abstract

Mesenchymal stromal cells or mesenchymal stem cells obtained from bone marrow (BMMSCs) are adult stem cells with interesting qualities in regenerative medicine, since they have the ability to differentiate between mesenchymal tissue cells and lung, neuronal and liver tissue cells, among others. Likewise, other features consist of immunomodulatory properties based on migration to inflamed tissue, the release of anti-inflammatory molecules, the differentiation between specific tissue, and the release of exosomes. Finally, some studies have explored their microbicidal capacity, which can be direct (the release of antimicrobial molecules and processes such as phagocytosis) or indirect (the release of mediators that activate other cells or immune mechanisms). Considering the aforementioned properties, BMMSCs have been postulated as a promising therapeutic alternative in the treatment of autoimmune and inflammatory diseases, either by autologous transplants or purification of their exosomes. This review aims to describe the main molecular and immunological mechanisms associated with the immunomodulatory and microbicidal capacity of BMMSCs in experimental models of some infectious diseases such as paracoccidioidomycosis, candidiasis, aspergillosis, tuberculosis, and COVID19 among others, with the aim of their being proposed for future human clinical trials.

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Author Biography

Julián Camilo Arango Rincón, University of Antioquia

Group of Medical and Experimental Mycology, Corporation for Biological Research. School of Microbiology, University of Antioquia.

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