Sistematización de las investigaciones que evalúan  la asociación de la infección con parásitos y cáncer

Andres Mauricio Calderón; Yeison Panesso Restrepo; Ana Luz Galván Díaz; Astrid Milena Bedoya

doi:10.17533/udea.hm.335241

Authors

Andres Mauricio Calderón University of Antioquia
Yeison Panesso Restrepo University of Antioquia
Ana Luz Galván Díaz University of Antioquia https://orcid.org/0000-0002-2127-4209
Astrid Milena Bedoya University of Antioquia

DOI:

https://doi.org/10.17533/udea.hm.335241

Keywords:

parasites, cancer, carcinogenesis, biomarker, tumor, neoplasia

Abstract

IntroductIon: cancer is one of the main causes of death in the world. It is estimated that between 16 and 20% of cancer cases are produced by infectious agents. The aim of this review was to systematize studies that describe the relationship between para-sites and cancer.

Methods: a systematic review of original stud-ies was conducted by completing the identification, screening, eligibility and inclusion phases. The repro-ducibility of the study was guaranteed through the ap-plication of the research protocol by two researchers, independently.

Results: out of 233,613 publications identified in the electronic databases, a total of 229 articles were included in this study. A total of twenty-seven (27) parasites were found to be associated with thirty-nine (39) types of cancer. Helminths constituted the main group of parasites related to cancer, being Schistosoma haematobium the most commonly studied. The descrip-tive (n = 86) and experimental (n = 75) studies were the most frequent, while few cohort studies (n = 3) and cases and controls (n = 1) were reported. The mechanism of carcinogenesis was established for 9 parasite species, three (3) of which are classed by the International Agency for Research on Cancer (IARC) as group 1 carcinogens (Clonorchis sinensis, Opisthorchis viverrini and Schistosoma haematobium), and one (1) as 2B subgroup (Schistosoma japonicum), which includes pos-sible carcinogens.

Conclusion: the studies showed thatparasites not included by the IARC in its classification are de-scribed as carcinogenic. The fact that their potential as carcinogens is still overlooked may represent an important cause of cancer.

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Author Biographies

Andres Mauricio Calderón, University of Antioquia

Microbiologist and Bioanalyst, School of Microbiology, University of Antioquia.

Yeison Panesso Restrepo, University of Antioquia

Microbiologist and Bioanalyst, School of Microbiology, University of Antioquia.

Ana Luz Galván Díaz, University of Antioquia

Professor, School of Microbiology. Researcher, Environmental Microbiology Group, School of Microbiology, University of Antioquia.

Astrid Milena Bedoya, University of Antioquia

School of Microbiology, University of Antioquia.

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