NANOPARTÍCULAS DE SÍLICE: ENCAPSULACIÓN DE FÁRMACOS Y TRATAMIENTO DE ENFERMEDADES

Natalia| Jaramillo; Carlos Paucar; Claudia Garcia

doi:10.17533/udea.rcm.19345

Authors

Natalia| Jaramillo National University of Colombia
Carlos Paucar National University of Colombia
Claudia Garcia National University of Colombia

DOI:

https://doi.org/10.17533/udea.rcm.19345

Keywords:

Silica nanoparticles, Encapsulating a drug, Reverse micelles

Abstract

In the world there is a great demand for effective technologies and diagnostictreatment of diseases,which it seeks to have dominion over them and prolong theaverage life of society. Traditional methodologies for treatingdiseases, not only have the ability to direct the drug to its site of action, but notconcentrations can keep it for as long and therapeutically levelsnecessary. Furthermore, they have premature release, or otherwise are expelled from the nichecell after a given time without having complied fully their task [1-4]. For thisreason, it becomes a first-order purpose;advancing unconventional therapiesallow pave the way in solving these problems. In the present work,we reported the synthesis of silica nanoparticles, capable to detect and treatmentproper diseases through the encapsulation of a drug. Likewise, it includesmorphological characterization of nanoparticles and some progress made intheiruse dispersibility physiological fluids.

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Author Biographies

Natalia| Jaramillo, National University of Colombia

Chemical Engineer, Master Student in Materials and Processes Engineering, Ceramic and Vitreous Group, National University of Colombia, Medellín Headquarters, Colombia

Carlos Paucar, National University of Colombia

Professor, School of Chemistry, Ceramic and Vitreous Group, National University of Colombia, Medellín Headquarters, Colombia

Claudia Garcia, National University of Colombia

Professor of the School of Physics, Ceramic and Vitreous Group, National University of Colombia, Medellín Headquarters, Colombia

References

Brigger, C., Dubernet, and e. al, “Nanoparticles in cancer therapy and diagnosis”. Adv. DrugDeliv Rev, 2002. 54: páginas,631–651.

Dubernet, B. and P. Couvreur, “Nanoparticles in cancer therapy and diagnosis”. Adv.Drug Delivery Rev, 2002. 54: páginas,631-651.

Manish, G. and S. Vimukta, “Targeted drug delivery system: A Review”. Res. J. Chem. Sci, 2011. 1(2): páginas,135-138.

Moghimi, S.M., A.C. Hunter, and e. al, “Long-circulating and target specific nanoparticles: theory to practice”. Pharmacol Rev, 2001. 53: páginas,283–318.

Wang, M. and M. Thanou, “Targeting nanoparticles to cancer”. Pharmacological Research. 62(2): páginas,90-99.

Haley, B. and E. Frenkel, “Nanoparticles for drug delivery in cancer treatment”. Urologic oncology, 2008. 26(1): páginas,57-64.

Tang, D., R. Yuan, and e. al, “Signal amplification of electrochemical immunosensor for the detection of human serum IgG using double-codified nanosilica particles as labels Clinical chemestry”, 2007. 53: páginas,1323-1329.

Carturan, G., et al., “Encapsulation of functional cells by sol–gel silica: actual progress and perspectives for cell therapy”. J. Mater. Chem, 2004. 14: páginas. 2087-2098.

Andrade, A. and e. al, “Análisis de las reacciones de hidrólisis y condensación en muestras de sílica xerogeles usando espectroscopía infrarroja”. Rev. Mex. Fís, 2000. 46: páginas,593.

Bi, L. and e. al, “Multifunctional organic-inorganic multilayer films of tris(2,2'-bipyridine)ruthenium and decatungstate”. Electrochemistry Communications, 2003. 5(11): páginas,913-918.

Katumba, G., M. B.W, and T.R. Mothibinyane, “FTIR and Raman Spectroscopy of Carbon Nanoparticles in SiO2, ZnO and NiO Matrices”. Nanoscale Research Letters. 3(11): páginas,421-426.

Liu, L. and H. Gao, Molecular structure and vibrational spectra of ibuprofen using density function theory calculations. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 89(0): páginas,201-209.

Vueba, M.L., M.E. Pina, and L.A.E. Batista de Carvalho, “Conformational stability of ibuprofen: Assessed by DFT calculations and optical vibrational spectroscopy”. Journal of Pharmaceutical Sciences, 2008. 97(2): páginas,845-859.