Detection of irregular antibodies in transfused patients in a clinic at Medellín, Colombia between 2007 and 2010

Authors

  • María Isabel Villa P. University of Antioquia
  • Rocío Pérez E. University of Antioquia
  • Jaiberth Cardona A. University of Antioquia

DOI:

https://doi.org/10.17533/udea.hm.18733

Keywords:

antibodies, irregular, blood transfusion

Abstract

Introduction
Irregular antibodies are one of the main complications of blood transfusion.
 
objective
To determine the prevalence of irregular antibodies in blood receptors from a clinic in Medellín, Colombia during the period of June 2007 to June 2010 and its association with demographic, clinical and hematological features.
 
Materials and Methods
Cross sectional study in 6420 blood receptors. The information was collected and analyzed in SPSS 18 through summary measures, frequencies, confidence intervals and nonparametric statistics.
 
Results
The prevalence of irregular antibodies was 1.1%, there was a 14.8% anti E, 9.8% anti D and 4.9% anti Kell, the frequency of anti C, anti c, anti S, anti Le , anti M and anti Fy was less than 4%. There was no difference in antibody prevalence by age, sex, diagnosis, ABO group and number of transfusions, there was an association with Rh and crossmatch test.
 
Conclusions
The prevalence of irregular antibodies was low and it had no association with the demographic and clinical
characteristics of the receptors.
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Author Biographies

María Isabel Villa P., University of Antioquia

*MSc Microbiology and Bioanalysis, Molecular Hemopathology Research Group, Professor at the School of Microbiology, University of Antioquia. Medellín Colombia.

Rocío Pérez E., University of Antioquia

MSc Education, Molecular Hemopathology Research Group, Professor at the School of Microbiology, University of Antioquia. Medellin Colombia.

Jaiberth Cardona A., University of Antioquia

MSc Epidemiology, Health and Sustainability Research Group, Professor at the School of Microbiology, University of Antioquia. Medellin Colombia.

References

Ameen R, Al shemmari s, Al-Bashir A. Red blood cell alloimmunization among sickle cell Kuwaiti Arab patients who received red blood cell transfusion. Transfus. 2009; 49: 1649-54.

Jalada P, Rinku s, snehalata G. Red cell alloimmu-nization in multitransfused patients and multipa-rous women. Indian J Hematol Blood Transfus. 2009; 25: 49-52.

Tormey C, Fisk J, stack G. Red blood cell alloantibo-dy frequency, specificity, and properties in a population of male military veterans. Transfus. 2008; 48: 2069-76.

Bashawri m, Ahmed m. Red Cell Alloimmunization in Thalassaemia Patients Bahrain Medical Bulletin. 2005; 27.

schonewille H, Van de Watering l, loomans D, Brand A. Red blood cell alloantibodies after trans-fusion: factors influencing incidence and specificity. Transfus. 2006; 46: 250-6.

Ameen R, Al-eyaadi O, Al-shemmari s, Chowdhury R, Al-Bashir A. Frequency of red blood cell alloanti-body in Kuwaiti population. Med Princ Pract. 2005; 14: 230-4.

natukunda B, schonewille H, ndugwa C, Brand A. Red blood cell alloimmunization in sickle cell di-sease patients in Uganda. Transfus. 2010; 50: 20-5.

natukunda B, Brand A, schonewille H. Red blood cell alloimmunization from an African perspective. Curr Opin Hematol. 2010; 17: 565-70.

murao m, Viana mB. Risk factors for alloimmuniza-tion by patients with sickle cell disease. Braz J Med Biol Res. 2005; 38: 675-82.

santos F, magalhães K, mota R, Pitombeira m. Post-Transfus red cell alloimmunisation in pa-tients with acute disorders and medical emergencies Rev bras hematol hemoter 2007; 29: 369-72.

Bauer m, Wiersum-Osselton J, schipperus m, Van-denbroucke JP, Briet e. Clinical predictors of alloim-munization after red blood cell transfusion. Transfus. 2007; 47: 2066-71.

Winters J, Pineda A, Gorden l, Bryant s, melton l, Vamvakas e, et al. RBC alloantibody specificity and antigen potency in Olmsted County, Minnesota. Transfus. 2001; 41: 1413-20.

Aygun B, Padmanabhan s, Paley C, Chandraseka-ran V. Clinical significance of RBC alloantibodies and autoantibodies in sickle cell patients who received transfusions. Transfus. 2002; 42: 37-43.

Wang l, liang D, liu H, Chang F, Wang C, Chan Y, et al. Alloimmunization among patients with transfu-sion-dependent thalassemia in Taiwan. Transfus Med. 2006; 16: 200-3.

Karimi m, nikrooz P, Kashef s, Jamalian n, Davatol-hagh Z. RBC alloimmunization in blood transfusion-dependent beta-thalassemia patients in southern Iran. Int J Lab Hematol. 2007; 29: 321-6.

Gader A, Al Ghumlas A, Al-momen A. Transfusion medicine in a developing country - alloantibodies to red blood cells in multi-transfused patients in Saudi Arabia. Transfus Apher Sci. 2008; 39: 199-204.

Chapman J, elliott C, Knowles s, milkins C, Poole G. Guidelines for compatibility procedures in blood transfusion laboratories. Transfus Med. 2004; 14:59-73.

Daniels G, Poole J, de silva m, Callaghan T, ma-clennan s, smith n. The clinical significance of blood group antibodies. Transfus Med. 2002; 12:287-95.

Gader AG, Al Ghumlas AK, Al-momen AK. Transfu-sion medicine in a developing country - alloantibo-dies to red blood cells in multi-transfused patients in Saudi Arabia. Transfus Apher Sci. 2008; 39(3): 199-204.

Dueñas V, Cortez A, Rovetto P, neuta PA. Embara-zo y transfusión y su asociación con aloanticuerpos inesperados de significancia clínica contra antígenos eritrocitarios. Colomb Med. 1999; 30.

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Published

2014-03-03

How to Cite

Villa P., M. I., Pérez E., R., & Cardona A., J. (2014). Detection of irregular antibodies in transfused patients in a clinic at Medellín, Colombia between 2007 and 2010. Hechos Microbiológicos, 3(2), 17–24. https://doi.org/10.17533/udea.hm.18733

Issue

Vol. 3 No. 2 (2012)

Section

Artículos de investigación original
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