Anormalidad de Pseudo Chediak-Higashi en un caso de Leucemia Mieloide Aguda, observado en sangre periférica

Patricia E. Jaramillo A.

doi:10.17533/udea.hm.20185

Authors

Patricia E. Jaramillo A. Universidad de Antioquia

DOI:

https://doi.org/10.17533/udea.hm.20185

Keywords:

pseudo Chediak Higashi granules, acute myeloid leukemia, translocation t(8;21)(q22;q22) (RUNX1T1), peripheral blood smear

Abstract

Pseudo Chediak Higschi granules have been reported in myeloid neoplasms, especially in acute myeloid leukemias with maturation and with translocation t(8;21)(q22;q22) (RUNX1T1). These granules are different to Auer bodies and they correspond to fine, larger and irregular intra-cytoplasmic structures. Herein, hematological findings of a patient with diagnosis of acute myeloid leukemia are presented, in accordance with World Health Organization criteria. In the peripheral blood smear, unique or multiple Pseudo Chediak Higashi granules with a pink color and crystalloid aspect were observed, especially in blast cells and neutrophilic myelocites.

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Author Biography

Patricia E. Jaramillo A. , Universidad de Antioquia

Bacteriologist Hematologist, MS. Microbiology with an Emphasis on Hematology. Professor at the University of Antioquia, León XIII Clinic. Medellin Colombia.

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