Effects of ivermectin on cytokine and immunoglobulin levels in sheep
DOI:
https://doi.org/10.17533/udea.rccp.v36n4a5Keywords:
avermectins, immunity, immunoglobulin E, immunoglobulin G, immunoglobulin M, interferon-α, interleukin-2, interleukin-6, interleukin-10, ivermectin, sheep, tumor necrosis factor-αAbstract
Background: Ivermectin may affect the levels of cytokines and immunoglobulins in sheep, considering that avermectins have an effect on the immune system. Objective: To determine whether ivermectin has an effect on cytokines and immunoglobulins in sheep. Methods: After administration of ivermectin to 10 healthy sheep, sheep-specific interferon-α, tumor necrosis factor-α, interleukin-2, interleukin-6, interleukin-10, immunoglobulin G, immunoglobulin M, and immunoglobulin E levels were measured with an ELISA reader. Results: Significant (p<0.05) fluctuations were detected in interleukin-2 and interleukin-10 levels. Transient increases (p<0.05) were measured in tumor necrosis factor-α and immunoglobulin E levels (p<0.05). Conclusion: Ivermectin may affect immune system parameters in healthy sheep; however, the effects of ivermectin administration on infected sheep should be investigated.
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