Effects of ivermectin on cytokine and immunoglobulin levels in sheep

Rahmi Canbar; Irmak Dik; Muhittin Uslu; Merve Ider; Mustafa-Sedat Arslan; Enver Yazar

doi:10.17533/udea.rccp.v36n4a5

Authors

Rahmi Canbar Necmettin Erbakan University
Irmak Dik Selcuk University
Muhittin Uslu Yozgat Bozok University
Merve Ider Selcuk University
Mustafa-Sedat Arslan Selcuk University
Enver Yazar Selcuk University

DOI:

https://doi.org/10.17533/udea.rccp.v36n4a5

Keywords:

avermectins, immunity, immunoglobulin E, immunoglobulin G, immunoglobulin M, interferon-α, interleukin-2, interleukin-6, interleukin-10, ivermectin, sheep, tumor necrosis factor-α

Abstract

Background: Ivermectin may affect the levels of cytokines and immunoglobulins in sheep, considering that avermectins have an effect on the immune system. Objective: To determine whether ivermectin has an effect on cytokines and immunoglobulins in sheep. Methods: After administration of ivermectin to 10 healthy sheep, sheep-specific interferon-α, tumor necrosis factor-α, interleukin-2, interleukin-6, interleukin-10, immunoglobulin G, immunoglobulin M, and immunoglobulin E levels were measured with an ELISA reader. Results: Significant (p<0.05) fluctuations were detected in interleukin-2 and interleukin-10 levels. Transient increases (p<0.05) were measured in tumor necrosis factor-α and immunoglobulin E levels (p<0.05). Conclusion: Ivermectin may affect immune system parameters in healthy sheep; however, the effects of ivermectin administration on infected sheep should be investigated.

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Author Biographies

Rahmi Canbar, Necmettin Erbakan University

Department of Pharmacology and Toxicology, Veterinary Medicine, Necmettin Erbakan University, 42310, Eregli, Konya, Turkey
https://orcid.org/0000-0001-7100-4437

Irmak Dik, Selcuk University

Department of Virology, Faculty of Veterinary Medicine, Selcuk University, 42130, Selcuklu, Konya, Turkey
https://orcid.org/0000-0003-2516-9489

Muhittin Uslu, Yozgat Bozok University

Laboratory and Veterinary Health Program, Sefaatli Veterinary Department, Yozgat Bozok University, 66800, Sefaatli, Yozgat, Turkey
https://orcid.org/0000-0002-9027-4229

Merve Ider, Selcuk University

Department of Internal Medicine, Faculty of Veterinary Medicine, Selcuk University, 42130, Selcuklu, Konya, Turkey
https://orcid.org/0000-0003-2928-5452

Mustafa-Sedat Arslan, Selcuk University

Department of Anatomy, Faculty of Veterinary Medicine, Selcuk University, 42130, Selcuklu, Konya, Turkey
https://orcid.org/0000-0002-4079-500X

Enver Yazar, Selcuk University

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Selcuk University, 42130, Selcuklu, Konya, Turkey
https://orcid.org/0000-0002-6508-7245

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