Effects of ivermectin on cytokine and immunoglobulin levels in sheep
DOI:
https://doi.org/10.17533/udea.rccp.v36n4a5Keywords:
avermectins, immunity, immunoglobulin E, immunoglobulin G, immunoglobulin M, interferon-α, interleukin-2, interleukin-6, interleukin-10, ivermectin, sheep, tumor necrosis factor-αAbstract
Background: Ivermectin may affect the levels of cytokines and immunoglobulins in sheep, considering that avermectins have an effect on the immune system. Objective: To determine whether ivermectin has an effect on cytokines and immunoglobulins in sheep. Methods: After administration of ivermectin to 10 healthy sheep, sheep-specific interferon-α, tumor necrosis factor-α, interleukin-2, interleukin-6, interleukin-10, immunoglobulin G, immunoglobulin M, and immunoglobulin E levels were measured with an ELISA reader. Results: Significant (p<0.05) fluctuations were detected in interleukin-2 and interleukin-10 levels. Transient increases (p<0.05) were measured in tumor necrosis factor-α and immunoglobulin E levels (p<0.05). Conclusion: Ivermectin may affect immune system parameters in healthy sheep; however, the effects of ivermectin administration on infected sheep should be investigated.
Downloads
References
Akdogan M, Yontem M. Cytokines. OTSBD; 2018; 3:36-45. https://doi.org/10.26453/otjhs.350321
Amarasekera M. Immunoglobulin E in health and disease. Asia Pac Allergy 2011; 1:12-15. https://doi.org/10.5415/apallergy.2011.1.1.12
Ashour DS. Ivermectin: From theory to clinical application. Int J Antimicrob Ag 2019; 54:134- https://doi.org/142.10.1016/j.ijantimicag.2019.05.003
Bekdur Y, Aslan O, Senturk M, Cigdem M. The effect of ivermectin on serum TNF-α and IL-6 levels in bovine papillomatosis. J Health Sci 2018; 26:156-161. https://dergipark.org.tr/tr/pub/eujhs/issue/44575/553263
Blakley BR, Rousseaux CG. Effect of ivermectin on the immune response in mice (abstract). Am J Vet Res 1991; 52:593-595. https://pubmed.ncbi.nlm.nih.gov/1828942/
Ci X, Li H, Yu Q, Zhang X, Yu L, Chen N, Song Y, Deng X. Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway. Fundam Clin Pharmacol 2009; 23:449-455. https://doi.org/10.1111/j.1472-8206.2009.00684.x
Omer MO, Ashra M, Javeed A, Maqbool A. Immunostimulatory effect of ivermectin on macrophage engulfment and delayed type hypersensitivity in broilers. J Anim Plant Sci 2012; 22:250-255. www.thejaps.org.pk/docs/v-22-2/01.pdf
Paradis M. New approaches to the treatment of canine demodicosis. Vet Clin North Am Small Anim 1999; 29:1425-1436. https://doi.org/10.1016/s0195-5616(99)50136-8
Shimogawara R, Hata N, Schuster A, Lesshafft H, De Oliveira SG, Ignatius R, Akao N, Ohta N, Feldmeier H. Hookworm-related cutaneous larva migrans in patients living in an endemic community in Brazil: immunological patterns before and after ivermectin treatment. Eur J Microbiol Immunol 2013; 3:258-266. https://doi.org/10.1556/EuJMI.3.2013.4.4
Uhlir J, Volf P. Ivermectin: its effect on the immune system of rabbits and rats infested with ectoparasites. Vet Immunol Immunopathol 1992; 34:325-336. https://doi.org/10.1016/0165-2427(92)90173-n
Ventre E, Rozieres A, Lenief V, Albert F, Rossio P, Laoubi L, Dombrowicz D, Staels B, Ulmann L, Julia V, Vial E, Jomard A, Hacini-Rachinel F, Nicolas JF, Vocanson M. Topical ivermectin improves allergic skin inflammation. Allergy 2017; 72:1212-1221. https://doi.org/10.1111/all.13118
Yan S, Ci X, Chen N, Chen C, Li X, Chu X, Li J, Deng X. Anti-inflammatory effects of ivermectin in mouse model of allergic asthma. Inflamm Res 2011; 60:589-596. https://doi.org/10.1007/s00011-011-0307-8.
Yazar E. Chemotherapeutics. In: Yazar E, editor. Veterinary Drug Guide and Treatment Handbook. Istanbul: Nobel Tip Publisher; 2020. p.81-233.
Yilmaz N, Akgul Y. Immunoglobulins and septicemia. Uludag Univ J Fac Vet Med 2014; 33:33-42. https://dergipark.org.tr/tr/download/article-file/412339
Zhang X, Song Y, Ci X, An N, Ju Y, Li H, Wang X, Han C, Cui J, Deng X. Ivermectin inhibits LPS-induced production of inflammatory cytokines and improves LPS-induced survival in mice. Inflamm Res 2008; 57:524-529. https://doi.org/10.1007/s00011-008-8007-8
Downloads
Published
Versions
- 2024-09-25 (2)
- 2023-07-12 (1)
How to Cite
Issue
Section
License
Copyright (c) 2021 Revista Colombiana de Ciencias Pecuarias
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The authors enable RCCP to reprint the material published in it.
The journal allows the author(s) to hold the copyright without restrictions, and will allow the author(s) to retain publishing rights without restrictions.
