Pituitary tumor diagnosis using gadolinium-enhanced magnetic resonance imaging in a dog with hyperadrenocorticism. A case report
DOI:
https://doi.org/10.17533/udea.rccp.324102Palavras-chave:
canine, Cushing, imaging, pituitary, tumoral biologyResumo
Summary
Cushing's disease is a common endocrine disorder of dogs, caused by persistent high concentration of cortisol in circulating blood. Almost eighty five percent of the cases of spontaneous hyperadrenocorticism in dogs are the result of a functional pituitary tumor or hyperplasia. Advanced imaging techniques like computed tomography (CT) or magnetic resonance imaging (MRI) are the best means to obtain a diagnosis of a pituitary tumor in dogs with pituitary-dependent hyperadrenocorticism (PDH). Moreover these imaging techniques are required to asses the size and location of the pituitary tumor when planning surgical removal of the tumor mass or of the complete pituitary gland. In Colombia, the use of these imaging techniques is very limited in the small animal practice, but it has recently become available for veterinary patients thanks to agreements with human clinical institutions. This report describes the case of an eleven year-old golden retriever with PDH as a result of a functional pituitary tumor, visualized by magnetic resonance imaging using gadolinium as contrast agent.
Resumen
La enfermedad de Cushing es un trastorno endocrino común en perros causado por altas y persistentes concentraciones de cortisol en sangre. Casi el 85% de los casos de hiperadrenocorticismo espontáneo en perros son el resultado de un tumor funcional o una hiperplasia pituitaria. Las técnicas avanzadas de diagnóstico por imagen como la tomografía axial computarizada (TAC) o la resonancia magnética (RM) son los mejores métodos para obtener el diagnóstico de un tumor pituitario en pacientes con hiperadrenocorticismo dependiente de la hipófisis (PDH). Además estas técnicas son necesarias para determinar el tamaño y localización del tumor pituitario cuando se planea la extracción quirúrgica de la masa o la hipófisis completa. En nuestro país, el uso de estas técnicas por imagen está muy restringido en la práctica de pequeñas especies, sin embargo recientemente han estado disponibles para los pacientes veterinarios gracias al uso de instituciones médicas humanas. En este reporte se describe el caso de un Golden retriever de 11 años con PDH como resultado de un tumor funcional pituitario, que fue visualizado usando RM utilizando gadolinio como medio de contraste.
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Referências
Axlund TW, Behrend EN. Surgical treatment of canine Hyperadrenocorticism. Compendium 2003; 25: 334-347.
Behrend E, Kemppainen RJ, Clark TP. Diagnosis of hyperadrenocorticism in dogs: a survey of internists and dermatologists. JAVMA 2002; 220: 1643-1649. DOI: https://doi.org/10.2460/javma.2002.220.1643
Duesburg C, Feldman E, Richard W et . al. Magnetic resonance imaging for diagnosis of pituitary macrotumors in dogs. JAVMA 1995; 206: 657-662. DOI: https://doi.org/10.2460/javma.1995.206.05.657
Feldman EC, Nelson RW. Hyperadrenocorticism (Cushing’s syndrome). In: Feldman BF, Nelson RW (editors): Canine and feline endocrinology and Reproduction, 2nd ed. Philadelphia: WB Saunders; 1996. p 187-265.
Feldman EC, Nelson RW, Feldman MS. Use of low- and high-dose dexamethasone tests for distinguishing pituitary-dependent from adrenal tumor hyperadrenocorticism in dogs. JAVMA 1996; 209:772-775. DOI: https://doi.org/10.2460/javma.1996.209.04.772
Goldstein EJ, Burnett KR, Wolf GL, et.al. Contrast enhancement of spontaneous animal CNS tumors with gadolinium DTPA: a correlation of MRI with x-ray CT). Physiol Chem Phys Med NMR 1985; 17: 113-122.
Guptill L, Scott-Moncrieff JC, Widmer W. Diagnosis of canine hyperadrenocorticism. Vet Clin North Am Small Anim Prac 1997; 27:215-225. DOI: https://doi.org/10.1016/S0195-5616(97)50028-3
Hall WA, Luciano M, Doppman Jl, Patrpmas NJ, et.al. Pituitary Magnetic Resonance Imaging in Normal Human Volunteers Occult Adenomas in the General Population. Ann Intern Med1994; 120: 817-820. DOI: https://doi.org/10.7326/0003-4819-120-10-199405150-00001
Pooya HA. Magnetic Resonance Imaging in Small Animal Medicine: Clinical Applications. Compendium 2004; 26: 292-301.
Snellman M. Magnetic resonance Imaging in canine spontaneous neurological disorders: an evaluation of equipment and methods. Academic Dissertation presented in the Auditorium Maximum, Helsinki. 2000.
Tucker RL, Gavin PR. Brain imaging. Vet Clin North Am Small Anim Pract 1996; 26: 735-758. DOI: https://doi.org/10.1016/S0195-5616(96)50103-8
Van der Vlugt-Meijer RH, Voorhout G, P. Meij B. Imaging of the pituitary gland in dogs with pituitary-dependent hyperadrenocorticism. Mol Cel endocrinal 2002.197: 81-87. DOI: https://doi.org/10.1016/S0303-7207(02)00282-4
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