Influencia del factor de crecimiento fibroblástico 2 en células madre in vitro

Autores/as

DOI:

https://doi.org/10.17533/udea.acbi.v41n111a03

Palabras clave:

FGF-2, proliferación celular, senescencia, terapia celular

Resumen


El interés y la necesidad de estudiar las células madre en terapias regenerativas han aumentado en los últimos años debido a su capacidad de proliferación y diferenciación hacia múltiples linajes. Desafortunadamente, el número de células demandado para un trasplante satisfactorio es mayor al que se logra extraer directamente del paciente, por lo que se deben realizar cultivos in vitro de células madre. Sin embargo, con el tiempo las células de estos cultivos se vuelven senescentes, disminuyendo así su número de divisiones celulares y su capacidad proliferativa. Para solucionar esta problemática se han propuesto factores de crecimiento como agentes potenciadores de la proliferación celular. Entre estos se encuentra el factor de crecimiento fibroblástico 2, que al agregarse al medio podría promover la proliferación y aumentar el tiempo de vida de las células en cultivo. En la siguiente revisión se recopila información sobre la biología de este factor de crecimiento y el tipo de señalización que utiliza, al igual que sus aplicaciones en terapia regenerativa y su efecto en la proliferación celular y senescencia.

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Biografía del autor/a

Catalina Rubio-Vargas, Universidad del Tolima.

Facultad de Ciencias, Universidad del Tolima, Ibagué, Colombia. Grupo de modelos experimentales para las ciencias zoohumanas, Facultad de Ciencias, Universidad del Tolima, Ibagué, Colombia

Liliana Francis-Turner, Universidad del Tolima.

Facultad de Ciencias, Universidad del Tolima, Ibagué, Colombia. Grupo de modelos experimentales para las ciencias zoohumanas, Facultad de Ciencias, Universidad del Tolima, Ibagué, Colombia

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Publicado

2020-02-26

Cómo citar

Rubio Vargas, A. C., Alcázar Arzuza, J. P., & Francis Turner, L. (2020). Influencia del factor de crecimiento fibroblástico 2 en células madre in vitro. Actualidades Biológicas, 41(111), 1–8. https://doi.org/10.17533/udea.acbi.v41n111a03

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