Una mirada a las proteínas C3 y C5 en el Covid-19

Henry David Mosquera-Daza

doi:10.17533/udea.acbi.v43n115a05

Autores/as

Henry David Mosquera-Daza La Salle University https://orcid.org/0000-0001-6695-2539

DOI:

https://doi.org/10.17533/udea.acbi.v43n115a05

Palabras clave:

C3, C5, Complemento, Inhibición, SARS-CoV-2

Resumen

La emergencia causada por el nuevo virus SARS-CoV-2, causante de la enfermedad Covid-19, ha desencadenado una pandemia a nivel global. Uno de los factores más característicos de la infección por el virus SARS-CoV-2, es la activación desregulada del sistema del complemento, especialmente por parte las proteínas C3 y C5. Estas proteínas desencadenan reacciones de iniciación y de mantenimiento de actividades biológicas inadecuadas, además de respuestas inmunitarias descontroladas por parte de las células inmunes, en especial los neutrófilos. Generan diversas patologías como: accidente cerebrovascular agudo, ataque al corazón, coagulopatías, falla multiorgánica, inflamación, inmunotrombinosis, insuficiencia cardíaca, lesión renal aguda, lesiones agudas en el área pulmonar, microangiopatía trombótica, neumonía, y respuestas inmunes disfuncionales. Debido al rol crucial que presentan las proteínas C3 y C5 en la infección por el virus SARS-COV-2, nuevos tratamientos de inhibición del sistema del complemento han emergido como una posible primera línea de defensa contra los peores síntomas desarrollados durante la enfermedad Covid-19. En este artículo se revisará de manera general, el rol de las proteínas C3 y C5 y los tratamientos dirigidos a la inhibición de estas mismas proteínas durante la infección por SARS-CoV-2.

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Biografía del autor/a

Henry David Mosquera-Daza, La Salle University

Universidad de La Salle, Department of Basic Sciences, Bogotá, Colombia.

Citas

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