Cannabinoides no psicoactivos en cáncer: estudios in vivo

Autores/as

  • Julián Arango Universidad de Antioquia
  • Vanesa Bedoya Betancur Universidad Pontificia Bolivariana

DOI:

https://doi.org/10.17533/udea.hm.v11n1a04

Palabras clave:

cannabinoides, cannabidiol, inmunomodulación, ensayos in-vivo cáncer

Resumen


El cannabis alberga gran cantidad de compuestos con características de importancia en diversos procesos que incluyen los industriales, recreativos y medicinales. Los compuestos más abundantes en estas plantas son los cannabinoides, siendo los más importantes y estudiados el tetrahidrocannabinol (THC), un compuesto que a pesar de que se le han descrito múltiples propiedades medicinales y potencial terapéutico, su uso se ha visto limitado debido a sus efectos psicoactivos; y el cannabidiol (CBD) que se diferencia del anterior porque no presenta esta propiedad. Este último ha cobrado importancia por sus propiedades para tratar algunas enfermedades como el cáncer gracias a su efecto pro-apotótico, anti-proliferativo y anti-angiogénico. Esta revisión tiene como objetivo describir los mecanismos inmunomoduladores asociados a los cannabinoides no psicoactivos en modelos in vivo de diferentes tipos de cáncer como: glioblastoma, cáncer de seno, cáncer de pulmón, cáncer colorrectal y melanoma. Entre los hallazgos obtenidos en diferentes trabajos se destaca la capacidad de este compuesto, en combinación con otros fármacos antineoplásicos, de inducir apoptosis e inhibir la metástasis mediante la regulación de ciertas moléculas como CD31, Id-1, caspasas 3 y 9, y metaloproteinasas, entre otras. A pesar de que estos compuestos son vistos como prometedores fármacos, hacen falta más estudios que evalúen los mecanismos inmunomoduladores de los cannabinoides no psicoactivos, debido a que evidencias previas solo han descrito sus propiedades in vitro, por lo tanto, hace falta ahondar un poco más en el estudio de modelos in vivo, para un posible uso posterior en ensayos clínicos, y de esta forma ser considerados como verdaderos agentes terapéuticos.  

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Biografía del autor/a

Julián Arango, Universidad de Antioquia

Grupo de Micología Médica y Experimental, Corporación para Investigaciones Biológicas. Escuela de Microbiología, Universidad de Antioquia.

Vanesa Bedoya Betancur, Universidad Pontificia Bolivariana

Grupo de Micología Médica y Experimental, Corporación para Investigaciones Biológicas. Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana.          

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Publicado

2020-10-26

Cómo citar

Arango, J., & Bedoya Betancur, V. (2020). Cannabinoides no psicoactivos en cáncer: estudios in vivo. Hechos Microbiológicos, 11(1 y 2), 61–71. https://doi.org/10.17533/udea.hm.v11n1a04

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