Implementación de la tecnología CRISPR-Cas para el tratamiento de enfermedades en la acuicultura de peces: Revisión sistemática

Mighelangelo Santiago Arcila Quintero; Sara Michel Morales Polo

doi:10.17533/ udea.hm.v15n1a04

Authors

Mighelangelo Santiago Arcila Quintero Universidad de Antioquia https://orcid.org/0009-0004-8732-0409
Sara Michel Morales Polo Estudiante de pregrado de la escuela de microbiología

DOI:

https://doi.org/10.17533/%20udea.hm.v15n1a04

Keywords:

Aquiculture, control, crispr-cas, early diagnosis, fish diseases, treatment

Abstract

Introduction: Approximately 50% of production losses in aquaculture destined for human consumption are attributed to diseases caused by pathogens. Many traditional treatments for these diseases are prohibited due to their negative impacts on the environment, consumer health, or fish growth. Genetic modification, particularly through CRISPR-Cas technology, presents a promising solution. This technology enables precise genetic modifications and the detection of specific sequences with higher accuracy compared to other methods. Objective: To describe the applications of CRISPR-Cas technology in the treatment of fish diseases within the aquaculture industry. Methodology: A literature search was conducted using the terms aquaculture, CRISPR, CRISPR-Cas, CRISPR-Cas Systems, diseases, fish disease, treatment, treatments, and control. The search was limited to original articles published between 2014 and 2024 in English, and was conducted in ScienceDirect, Scopus, and Google Scholar. Results: Results indicate that China and the United States are leading in this field. Viral pathogens were most frequently studied, and Ictalurus punctatus and Salmo salar were the most common fish species. The most significant application of CRISPR-Cas is the diagnosis of viral and bacterial diseases through fluorescence. CRISPR-Cas is becoming an essential tool for the early diagnosis of fish diseases. Its use is expanding to address both bacterial and viral diseases due to the challenges associated with their treatment and control. Conclusions: Further research is necessary to confirm its efficacy and sustainability as a viable alternative for treating diseases in aquaculture.

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Author Biography

Mighelangelo Santiago Arcila Quintero, Universidad de Antioquia

Estudiante de la escuela de microbiología

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