Pharmacological treatment with cabergoline in three cats with acromegaly

Elber A. Soler Arias; Jorge D. García; Víctor A. Castillo

doi:10.17533/udea.rccp.v30n4a07

Authors

Elber A. Soler Arias University of Buenos Aires
Jorge D. García University of Buenos Aires
Víctor A. Castillo University of Buenos Aires

DOI:

https://doi.org/10.17533/udea.rccp.v30n4a07

Keywords:

diabetes, dopaminergic agonist, growth hormone, hypersomatotropism, IGF-1, insulin resistance

Abstract

Anamnesis: Three cats diagnosed with diabetes mellitus (DM) were referred for examination due to the presence of insulin resistance signs, which included polyuria, polydipsia, polyphagia and high fructosamine levels, even with insulin glargine doses greater than 2 U/Kg/application. Clinical and laboratory findings: All patients had enlarged facial features along with increased interdental space. The biochemical tests revealed high IGF-1 concentrations. The magnetic resonance imaging displayed enlarged pituitary gland in one of the cats and images compatible with a pituitary macroadenoma in the other two. Acromegaly was the final diagnosis. Treatment approach: Oral cabergoline at 10 μg/Kg every 48 h was administered. Conclusion: The treatment with cabergoline successfully decreased IGF-1 concentrations and all insulin resistance signs, and it enhanced glycemic control for the DM in the three cats. Our results suggest cabergoline could be used for the treatment of acromegaly in cats.

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Author Biographies

Elber A. Soler Arias, University of Buenos Aires

MV, Sp., Endocrinology Unit, Small Animal Medical Clinic Area, School Hospital, Faculty of Veterinary Sciences, University of Buenos Aires (UBA), Autonomous City of Buenos Aires, Argentina.

Jorge D. García, University of Buenos Aires

MV., Endocrinology Unit, Small Animal Medical Clinic Area, School Hospital, Faculty of Veterinary Sciences, University of Buenos Aires (UBA), Autonomous City of Buenos Aires, Argentina.

Víctor A. Castillo, University of Buenos Aires

MV., Endocrinology Unit, Small Animal Medical Clinic Area, School Hospital, Faculty of Veterinary Sciences, University of Buenos Aires (UBA), Autonomous City of Buenos Aires, Argentina.

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