De humanos a caninos: Desentrañando el impacto de la salud metabólica en el cáncer de mama entre especies
DOI:
https://doi.org/10.17533/udea.rccp.v38n3a4Palabras clave:
Biomarcadores, cáncer de mama, dieta y estilo de vida, obesidad, oncología comparativa, resistencia a la insulina, salud metabólica, tumor mamario caninoResumen
La relación entre la salud metabólica y el cáncer de mama emerge como un área en expansión en la oncología comparativa, destacada especialmente en estudios realizados entre humanos y caninos. Esta revisión explora cómo los hábitos dietéticos, la obesidad y los síndromes metabólicos influyen en el riesgo, la progresión y la respuesta a los tratamientos contra el cáncer de mama. Con este fin, se examina el impacto de la obesidad, la dieta y el estilo de vida en los mecanismos de carcinogénesis y el pronóstico en pacientes humanos y caninos afectados por tumores mamarios. Al revisar estudios comparativos que abordan la relación entre la salud metabólica y el cáncer de mama en mujeres y caninos, se identifican vías moleculares y bioquímicas comunes en ambas especies. Este enfoque proporciona una comprensión más amplia de las enfermedades oncológicas y su desarrollo, sugiriendo estrategias potenciales para la prevención, el diagnóstico y el tratamiento del cáncer de mama desde una perspectiva metabólica. Sin embargo, dado que esta área de investigación está en desarrollo, es necesario explorar nuevas líneas de investigación para comprender completamente la compleja relación entre la salud metabólica y el cáncer en diferentes especies desde perspectivas bioquímicas, moleculares, genéticas y epigenéticas, con el objetivo de obtener conocimientos valiosos que contribuyan al desarrollo de nuevas herramientas diagnósticas, pronósticas y terapéuticas.
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