De humanos a caninos: Desvendando o impacto da saúde metabólica no câncer de mama entre espécies
DOI:
https://doi.org/10.17533/udea.rccp.v38n3a4Palavras-chave:
Biomarcadores, câncer de mama, dieta e estilo de vida, obesidade, oncologia comparativa, resistência à insulina, saúde metabólica, tumor mamário caninoResumo
A relação entre saúde metabólica e câncer de mama emerge como uma área em expansão na oncologia comparativa, especialmente destacada em estudos conduzidos entre humanos e caninos. Esta revisão explora como hábitos alimentares, obesidade e síndromes metabólicas influenciam o risco, a progressão e a resposta aos tratamentos contra o câncer de mama. Para isso, examina-se o impacto da obesidade, da dieta e do estilo de vida nos mecanismos de carcinogênese e no prognóstico em pacientes humanos e caninos afetados por tumores mamários. Ao examinar estudos comparativos que abordam a relação entre saúde metabólica e câncer de mama em mulheres e caninos, são identificadas vias moleculares e bioquímicas comuns em ambas as espécies. Este enfoque proporciona uma compreensão mais ampla das doenças oncológicas e seu desenvolvimento, sugerindo estratégias potenciais para a prevenção, diagnóstico e tratamento do câncer de mama sob uma perspectiva metabólica. No entanto, dado que esta área de pesquisa ainda está em desenvolvimento, é necessário explorar novas linhas de pesquisa para compreender completamente a complexa relação entre saúde metabólica e câncer em diferentes espécies a partir de perspectivas bioquímicas, moleculares, genéticas e epigenéticas, com o objetivo de obter conhecimentos valiosos que contribuam para o desenvolvimento de novas ferramentas de diagnóstico, prognóstico e terapêuticas.
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