Lethal infection by Herpes simplex virus 1 (HSV-1) in a captive Azara's Owl Monkey (Aotus azarae) in Paraguay

J. Richard Vetter; Marlene Florentín-Morel; María-Graciela Riera-Domínguez; Ricardo G Cañiza

doi:10.17533/udea.rccp.38n3a5

Autores

J. Richard Vetter Universidad Nacional de Asunción https://orcid.org/0000-0002-4665-2659
Marlene Florentín-Morel Clinica Veterinaria Diego Dacak
María-Graciela Riera-Domínguez Laboratorio Meyer Lab https://orcid.org/0000-0002-4217-4960
Ricardo G Cañiza Universidad Nacional de Asunción

DOI:

https://doi.org/10.17533/udea.rccp.38n3a5

Palavras-chave:

Antropozoonose, Aotus azarae, Herpesvírus, Vírus herpes simplex, Paraguai, PCR, Platyrrhini, Primata do Novo Mundo

Resumo

Anamnese: Um Aotus azarae macho de 2 anos de idade foi trazido para a clínica de animais selvagens. O animal pesava 975 gramas e estava em baixa condição corporal. O indivíduo estava em contato próximo com os cuidadores e era principalmente alimentado pelas pessoas da casa, compartilhando suas refeições. De acordo com o cuidador, o animal estava astênico e anoréxico há aproximadamente dois dias. Achados clínicos e laboratoriais: Na inspeção clínica, o animal estava debilitado, com mucosa oral pálida e faringe hiperêmica, e temperatura retal de 34,2ºC. Crostas secas foram observadas na região perinasal e uma leve dispneia foi percebida. O paciente morreu durante a inspeção. O hemograma foi sugestivo de anemia normocítica normocrômica, leucopenia, hipoproteinemia e trombocitopenia. O resultado observado na análise molecular foi detectável para HSV-1. Conclusões: Os dados obtidos na anamnese e na história clínica, bem como os achados hematológicos e os resultados da PCR confirmaram o diagnóstico de infecção pelo HSV-1. Para o conhecimento dos autores, este é o primeiro relato da doença em um primata não humano no Paraguai.

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Biografia do Autor

J. Richard Vetter, Universidad Nacional de Asunción

Departamento de Recursos Faunísticos y Medio Natural, Facultad de Ciencias Veterinarias, Universidad Nacional de Asunción, Paragua
Refugio Silvestre Urutaú, Paraguay

Marlene Florentín-Morel, Clinica Veterinaria Diego Dacak

Clinica Veterinaria Diego Dacak, Paraguay

María-Graciela Riera-Domínguez, Laboratorio Meyer Lab

Departamento de Investigación y Docencia, Laboratorio Meyer Lab, Paraguay

Ricardo G Cañiza, Universidad Nacional de Asunción

Departamento de Recursos Faunísticos y Medio Natural, Facultad de Ciencias Veterinarias, Universidad Nacional de Asunción, Paraguay

Referências

Araújo JL, Frade MTS, Melo CMF, dos Santos Carneiro R, Galiza GJN, Olinda RG, Lucena RB & Dantas AFM. Infecção sistêmica por herpesvírus simples em um sagui-de tufo-branco (Callithrix jacchus) no semiárido da paraíba. Veterinária e Zootecnia 2016; 23(2):203–208. https://pesquisa.bvsalud.org/portal/resource/pt/vti-762783

Barahona H, Melendez LV, Hunt RD, Daniel MD. The owl monkey (Aotus trivirgatus) as an animal model for viral diseases and oncologic studies. Lab Anim Sci. 1976; 26(6):1104–1112. https://pubmed.ncbi.nlm.nih.gov/190472/

Calle PP, Joslin JO. New world and old world monkeys. In: Miller E, Fowler M, editors. Zoo and Wild Animal Medicine. 8th ed. St Louis: Elsevier Saunders; 2015. p.301–335. https://doi.org/10.1016/B978-1-4557-7397-8.00037-2

Casagrande RA. Herpesvirus simplex Tipo 1 (HSV-1) em sagüis (Callithrix jacchus e Callithrix penicillata)-Caracterização anatomopatológica e molecular (Doctoral dissertation). Universidade de São Paulo; 2007. https://doi.org/10.11606/D.10.2007.tde-20082007-133334

Casagrande RA. Herpesviroses em Primatas. In: Cubas ZS, Ramos Silva JC, Catao-Dias JL, editors. Tratado de Animais Selvagens. 2nd ed. Rio de Janeiro: Roca; 2014. Pp. 1321–1336.

Eberle R, Jones-Engel L. Understanding primate herpesviruses. J Emerging Dis Virol 2017; 3(1). https://doi.org/10.16966%2F2473-1846.127

Fortman JD, Hewett TA, Halliday LC. The laboratory nonhuman primate. 2nd ed. Florida: CRC Press; 2018. https://doi.org/10.1201/9781315117065

Gozalo AS, Montoya EJ, Weller RE. Dyscoria associated with herpesvirus infection in owl monkeys (Aotus nancymae). J Am Assoc Lab Anim Sci. 2008; 47(4):68–71. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694719/

Hatt JM, Grest P, Posthaus H, Bossart W. Serologic survey in a colony of captive common marmosets (Callithrix jacchus) after infection with herpes simplex type 1–like virus. J Zoo Wildl Med. 2004; 35(3):387–390. https://doi.org/10.1638/03-041

Huemer HP, Larcher C, Czedik-Eysenberg T, Nowotny N, Reifinger M. Fatal infection of a pet monkey with human herpesvirus 1. Emerg Infect Dis. 2002; 8(6):639. https://doi.org/10.3201%2Feid0806.010341

Imura K, Chambers JK, Uchida K, Nomura S, Suzuki S, Nakayama H, Miwa Y. Herpes simplex virus type 1 infection in two pet marmosets in Japan. J Vet Med Sci. 2014; 76(12):1667–1670. https://doi.org/10.1292/jvms.14-0374

Juan-Sallés C, Ramos-Vara JA, Prats N, Solé-Nicolás J, Segalés J, Marco AJ. Spontaneous herpes simplex virus infection in common marmosets (Callithrix jacchus). J Vet Diagn Invest. 1997; 9(3):341–345. https://doi.org/10.1177/104063879700900325

Katzin DS, Connor JD, Wilson LA, Sexton RS. Experimental herpes simplex infection in the owl monkey. Proc Soc Exp Biol Med. 1967; 125(2):391–398. https://doi.org/10.3181/00379727-125-32100

Kreutzer R, Kreutzer M, Günther CP, Mätz‐Rensing K, Wohlsein P. Systemic herpesvirus infection in an Azara’s Night Monkey (Aotus azarae). J Med Primatol. 2011; 40(3):197–199. https://doi.org/10.1111/j.1600-0684.2011.00469.x

Kukhanova MK, Korovina AN, Kochetkov SN. Human herpes simplex virus: life cycle and development of inhibitors. Biochem (Mosc). 2014; 79:1635–1652. https://doi.org/10.1134/S0006297914130124

Lapid R, Eshar D. Fatal Herpes simplex virus 1 (HSV-1) infection in a group of zoo-kept white-faced saki monkeys (Pithecia pithecia) in Israel. Isr J Vet Med. 2017; 72:51–55. https://www.ijvm.org.il/node/529

Ludlage E, Mansfield K. Clinical care and diseases of the common marmoset (Callithrix jacchus). Comp Med. 2003; 53(4):369–382. https://www.ingentaconnect.com/content/aalas/cm/2003/00000053/00000004/art00006

Mätz-Rensing K, Jentsch KD, Rensing S, Langenhuyzen S, Verschoor E, Niphuis H, Kaup FJ. Fatal Herpes simplex infection in a group of common marmosets (Callithrix jacchus). Vet Pathol. 2003; 40(4):405–411. https://doi.org/10.1354/vp.40-4-405

Meignier B, Martin B, Whitley RJ, Roizman B. In vivo behavior of genetically engineered herpes simplex viruses R7017 and R7020. II. Studies in immunocompetent and immunosuppressed owl monkeys (Aotus trivirgatus). J Infect Dis. 1990; 162(2):313–321. https://doi.org/10.1093/infdis/162.2.313

Melendez LV, Espana C, Hunt RD, Daniel MD, Garcia FG. Natural herpes simplex infection in the owl monkey (Aotus trivirgatus). Lab Anim Care. 1969; 19(1):38–45. https://pubmed.ncbi.nlm.nih.gov/4304237/

Nolasco Chumpitaz CE. Estudio retrospectivo de las historias clínicas de primates atendidos en el consultorio de animales silvestres y exóticos de la Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, durante el período 2005-2014 (Undergraduate dissertation). Universidad Nacional Mayor de San Marcos; 2017. https://hdl.handle.net/20.500.12672/7254

Roth JC, Cassady KA, Cody JJ, Parker JN, Price KH, Coleman JM, Peggins JO, Noker PE, Powers NW, Grimes SD, Carroll SL, Gillespie GY, Whitley RJ & Markert JM. Evaluation of the safety and biodistribution of M032, an attenuated herpes simplex virus type 1 expressing hIL-12, after intracerebral administration to Aotus nonhuman primates. Hum Gene Ther Clin Development. 2014; 25(1):16–27. https://doi.org/10.1089/humc.2013.201

Schrenzel MD, Osborn KG, Shima A, Klieforth RB, Maalouf GA. Naturally occurring fatal herpes simplex virus 1 infection in a family of white‐faced saki monkeys (Pithecia pithecia pithecia). J Med Primatol. 2003; 32(1):7–14. https://doi.org/10.1034/j.1600-0684.2003.01040.x

Sekulin K, Jankova J, Kolodziejek J, Huemer HP, Gruber A, Meyer J, Nowotny N. Natural zoonotic infections of two marmosets and one domestic rabbit with herpes simplex virus type 1 did not reveal a correlation with a certain gG-, gI-or gE genotype. Clin Microbiol Infect. 2010; 16(11):1669–1672. https://doi.org/10.1111/j.1469-0691.2010.03163.x

Souvignet T, Giorgiadis M, Drouet B, Quintard B. EAZA Best Practice Guidelines capuchin monkeys (Sapajus and Cebus sp.). Mulhouse: European Association of Zoos and Aquaria; 2019.

Takeshita RSC, Monteiro FOB, de Miranda Lins e Lins FL, da Silva GA, Faturi C, Coutinho LN, Monteiro MVB, Kugelmeier T, de Castro PHG & Muniz JAPC. Hematological, hepatic, and renal evaluation in Aotus azarai infulatus. J Med Primatol. 2011; 40(2):104–110. https://doi.org/10.1111/j.1600-0684.2010.00452.x

Todo T, Feigenbaum F, Rabkin SD, Lakeman F, Newsome JT, Johnson PA, Mitchell E, Belliveau D, Ostrove JM & Martuza RL. Viral shedding and biodistribution of G207, a muitimutated, conditionally replicating herpes simplex virus type 1, after intracerebral inoculation in Aotus. Mol Ther. 2000; 2(6):588–595. https://doi.org/10.1006/mthe.2000.0200

Wertheim JO, Smith MD, Smith DM, Scheffler K, Kosakovsky Pond SL. Evolutionary origins of human herpes simplex viruses 1 and 2. Mol Biol Evol. 2014; 31(9):2356–2364. https://doi.org/10.1093/molbev/msu185

Zinsser H. Herpes encephalitis in Cebus monkeys. J Exp Med. 1929; 49(4):661. https://doi.org/10.1084%2Fjem.49.4.661