Effects of extracellular osmolarity on membrane potential in articular chondrocytes
DOI:
https://doi.org/10.17533/udea.acbi.329434Keywords:
chondrocytes, mechanosensitive channels, membrane potential, osmolarityAbstract
Articular chondrocytes face continuous changes in their surrounding conditions, due to fluctuations of mechanic load during the movement of joints, which produce variations in the extracellular osmolarity. Chondrocytes respond activating ion and water fluxes in order to maintain their homeostatic conditions in response to these osmotic challenges. The present study assesses the effects of changes in extracellular osmolarity on membrane potential and the mechanisms that are involved in the articular bovine chondrocyte response. The hyperosmolarity caused membrane hyperpolarization and the hypoosmolarity caused membrane depolarization, but osmolarity values below 150 mOsm/l o above 400 mOsm/l did not cause additional changes. The hyperpolarization following hyperosmolarity was dependent on K+ efflux, through specific ionic channels, while depolarization following hypoosmolarity was dependent on Na+ influx through mechanosensitive cationic channels.
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