Perfil de resistencia a antimicrobianos de aislamientos clínicos de Clostridium, Paeniclostridium y Paraclostridium spp. (2015-2020)

Carlos Quesada-Gómez; Fabiola Rodriguez-Mena

doi:10.17533/udea.hm.v16n2a02

Authors

Carlos Quesada-Gómez Universidad de Costa Rica https://orcid.org/0000-0002-2293-8257
Fabiola Rodriguez-Mena Universidad de Costa Rica

DOI:

https://doi.org/10.17533/udea.hm.v16n2a02

Keywords:

Anaerobic bacteria, Antimicrobial resistance, antibiotic, Clostridium, Paraclostridium, Paeniclostridium

Abstract

Background: The genera Clostridium, Paraclostridium, and Paeniclostridium comprise Gram-positive, spore-forming, anaerobic bacteria widely distributed in the environment and human microbiota. Their ability to produce a broad range of toxins and their frequent exposure to antimicrobials confer high clinical relevance in diverse infections. Objective: To analyze resistance profiles to 11 antimicrobials in clinical isolates of these genera. Methods: A search and review of articles published in the period 2015-2020 in PubMed was carried out. Results: The highest resistance was observed against moxifloxacin, while tigecycline showed the lowest. Isolates with the highest resistance levels were mainly derived from traumatic wounds and bacteremia. A consistent finding was the comparatively lower resistance of C. perfringens compared to other species. Conversely, a C. innocuum strain exhibited a multidrug-resistant profile, with resistance to penicillin, clindamycin, and amoxicillin-clavulanic acid, in addition to its intrinsic resistance to vancomycin. Conclusion: These findings highlight the importance of active and continuous surveillance of antimicrobial resistance profiles in anaerobic bacteria, especially since such analyses are not routinely performed in clinical laboratories.

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