Racionalidad de los esquemas de superovulación y sincronización en la transferencia de embriones en bovinos: ¿terapéutica basada en la evidencia o ausencia de ética?

Authors

  • Juan Guillermo Maldonado Estrada
  • Paula A. Bolívar

DOI:

https://doi.org/10.17533/udea.rccp.324314

Keywords:

animal welfare, embryo donor, ethics in animal research, receptor cow, synchronization protocol, superovulation protocol

Abstract

Summary

Since the beginning of the use of bovine embryo transfer (ET) in Colombia, hormonal protocols for superovulation (SOV) of donors and for synchronization of recipients (RS) have been used in accordance with protocols reported elsewhere. Several variations of ET protocols have been reported most of they not based in controlled clinical studies but in the supposed pharmacological mechanisms of action of the used hormones, neither with pharmacokinetic studies nor considering the potential collateral effects on cow's fertility. Such collateral effects could be directly or indirectly related with the uncontrolled use of exogenous hormones, or with the time-related additional open days of donor and recipients, without considering the bioethics for animal experimentation. The huge proliferation of protocols for SOV and RS aims for improving both grade I and II (transferable or freezable embryos) embryo yield per transfer, and pregnancy rates for transferred embryos, without having achieved significant improvements during the last 20 years all around the world. In the present review we critic the use of exogenous hormones in bovine ET with emphasis in the rationality of indiscriminating use of exogenous hormones and embryo yield. Finally, we suggest several arguments on the bioethics of the protocols for SOV and RS in bovine ET.

 

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References

..Al.Katanami.YM,.Drost.M,.Monson.RL,.Rutledge.JJ,.Krininger.III.CE,.et al .. Pregnancy.rates.following.timed.embryo.transfer.with.fresh.or.vitrifed.in.vitro.produced.embryos.in.lactating.dairy.cows.under.heat.stress.condition ..Theriogenology.2002;.58:171-182 .

..Ax.RL,.Armbrust.S,.Tappan.R,.Gilbert.G,.Oyarzo.JN,.et al ..Superovulation.and.embryo.recovery.from.peripubertal.Holstein.heifers ..Anim.Reprod.Sci.2005;.85:71-80 .

Bader JF, Kojima FN, �ehrman ME, Lindsey BR, Kerley MS,.et al .. Effects.of.prepartum.lipid.supplementation.on.FSH.superstimulation.and.transferable.embryo.recovery.in.multiparous.beef.cows ..Anim.Reprod.Sci.2005;.85:61-70 ..

..Barros.CM,.Nogueira.MF ..Embryo.transfer.in.Bos indicus.cattle ..Theriogenology.2001;.56:1483-1496 ..

..Baruselli.PS,.De.Oliveira.M ..Últimos.avances.en.superovulación.de.donantes.de.razas.cebuinas ..IV.Seminario.Internacional.de.Reproducción.de.grandes.Animales ..2003 .

..Baruselli.PS,.De.Sá.Filho.MF,.Martins.CM,.Nasser.LF,.Nogueira.M,.et al .. Superovulation.and.embryo.transfer.in.Bos indicus.catlle ..Theriogenology.2006;.65:77-88 .

..Baruselli.PS,.De.sá.Filho.MF,.Martins.CM,.Reis.EL,.Nasser.LF,.et al .. Nuevos.avances.en.los.tratamientos.de.SOV. en.donadoras.de.embriones.bovinos ..Congreso.internacional.de.reproducción.bovina ..2005;.139-153 ..

..Benyei. B, . Gaspardy. A, . Cseh. S .. Effect. of . the. El . Nino.phenomenon. on . the. ovarian. responsiveness. and. embryo.production.of .donor.cows .. Acta.Vet.Hung.2003;.51:209-218 .

..Benyei.B,.Komlosi.I,. Pecsi.A,.Pollott.G,.Marcos.CH,.et al .. The.effect.of.internal.and.external.factors.on.bovine.embryo.transfer.results.in.a. tropical.environment ..Anim.Reprod.Sci.2005;.93:268-279 .

..Benyei.B,.Kulcsar.M,.Gaspardy.A,.Pecsi.A ..Progesterone.profiles and oestrous cycle changes following superovulatory treatment. of . Holstein-Friesian. dairy. cows. in . a. tropical.environment .. Acta.Vet.Hung.2004;.52:489-499 ..

..Bergfelt.DR,.Bo.GA,.Mapletoft.RJ,.Adams.GP ..Superovulatory.response.following.ablation-induced.follicular.wave.emergence.at. random.stages.of.the.oestrous.cycle.in.cattle ..Anim.Reprod.Sci.1997;.49:1-12 ..

..Bó.GA,.Baruselli.PS,.Chesta.PM,.Martins.CM ..The.timing.of.ovulation.and.insemination.schedules.in.superstimulated.cattle ..Theriogenology.2006;.65:89-101

Bolívar.PA,.MaldonadoEstrada.JGAnálisis.de.costos.de.tres.protocolos.de.transferencia.de.embriones.bovines.utilizados.en.Colombia ..Rev.Colomb.Cienc.Pecu.2008;.21:351-364 .

Brown.JG,.Peterson.DW,.Foote.WDReproductive.response.of.beef.cows.to.exogenous.progestogen,.estrogen.and.gonadotropins.at.various.stages.postpartum ..J. Anim.Sci.1972;.35:362-35369 ..

..Callesen.H,.Lovendahl.P,. Bak.A,.Greve.T ..Factors.affecting.the.developmental.stage.of.embryos.recovered.on.day.7. from.superovulated.dairy.cattle ..J. Anim.Sci.1995;.73:.1539-1543 ..

Caral Gutiérrez JP, Bernal del Sol AE. La súper ovulación en . el . ganado. bovino .. Capítulo. II .. In:. Iglesias. OC. (editor) ..Transferencia. de . embriones .. Centro. de . investigación. para.el mejoramiento animal (CIMA) Estación internacional de transferencia.de .embriones .. Valle.de .Picadura .. 1988 .. p47-92 .

..Chebel.RC,.Demétrio.DG,.Metzger.J ..Factors.affecting.success.of.embryo.collection.and.transfer.in.large.dairy.herds ..Theriogenology.2008;.69:98-106 .

Cifuentes-Sepúlveda E. Selección y manejo de donantes y.receptoras ..Curso.de.colecta,.selección,.transferencia.embriones.en.bovinos ..1999.

..Colazo.MG,.Martinez.MF,.Kastelic.JP,.Mapletoft.RJ ..Effects.of.dose.and.route.of.administration.of.cloprostenol.on.luteolysis,.estrus.and.ovulation.in.beef.heifers ..Anim.Reprod.Sci.2002;.72:47-62 .

Collier RJ, Dahl GE, VanBaale MJ. Major advances associated.with.environmental.effects.on.dairy.cattle ..J.Dairy.Sci.2006;.89:1244-1253 .

..D’Occhio.MJ,.Jillella.D,.Lindsey.BR ..Factors.that.influence follicle recruitment, growth and ovulation during ovarian.superstimulation.in.heifers:.opportunities.to.increase.ovulation.rate.and.embryo.recovery.by.delaying.the.exposure.of.follicles.to.LH ..Theriogenology.1999;.51:9-35 .

..D’Occhio.MJ,.Sudha.G,.Jillella.D,.Whyte.T,.Maclellan.LJ,.et al .. Close.synchrony.of.ovulation.in.superstimulated.heifers.that.have.a.downregulated.anterior.pituitary.gland.and.are.induced.to.ovulate.with.exogenous.LH ..Theriogenology.1998;.49:637-644 ..

..Evans. BR ..The. prospect. for. international. regulatory.interventions.in .embryo.transfer.and.reproductive.technologies.in .the.next.century .. Theriogenology;.1999;.51:71-80 .

..Galli.C,.Duchi.R,.Crotti.G,.Turini.P,.Ponderato.N,.et al ..Bovine.embryo.technologies ..Theriogenology.2003;.59:599-616 ..

..Ginther.OJ,.Wiltbank.MC,.Fricke.PM,.Gibbons.JR,.Kot.K ..Selection.of.the.dominant.follicle.in.cattle ..Biol.Reprod.1996;.55:1187-1194 .26 ..Ginther.OJ ..Selection.of.the.dominant.follicle.in.cattle.and.horses ..Anim.Reprod.Sci.2000;.2:.60-79 ..

..Gómez.Torres.CJ ..Transferencia.de.embriones.experiencias.en.Colombia ..Congreso.internacional.de.reproducción.bovina ..Bogotá ..2005;.155-157 .

..Gonzalez. A, . Wang. H, . Carruthers. TD,. Murphy. BD,.Mapletoft.RJ .. Superovulation.in .the.cow.with.pregnant.mare.serum.gonadotrophin:.effects.of .dose.and.anti-pregnant.mare.serum.gonadotrophin.serum .. Can.Vet.J.1994;.35:158-162 ..

..Goulding.D,.Williams.DH,.Roche.JF,.Boland.MP ..Superovulation.in.heifers.using.either.pregnant.mares.serum.gonadoptrophin.or.follicle.stimulating.hormone.during.the.mid.luteal.stage.of.the.estrous.cycle ..Theriogenology.1991;.36:949-958 .

..Gouveia.Nogueira.MF,.Fragnito.PS,.Trinca.LA,.Barros.CM ..The.effect.of.type.of.vaginal.insert.and.dose.of.pLH on embryo production, following fixed-time AI in a progestin-based.superstimulatory.protocol.in.nelore.cattle ..Theriogenology.2007;.67:655-660 .31 ..Guilbault.LA,.Grasso.F,.Lussier.JG,.Rouillier.P,.Matton.P ..Decreased.superovulatory.responses.in.heifers.superovulated.in.the.presence.of.a. dominant.follicle ..J.Reprod.Fertil.1991;.91:81-89 ..32 ..Hasler.JF .. The.current.status.and.future.of .commercial.embryo.transfer.in .cattle .. Anim.Reprod.Sci.2003;.79:245-264 .

..Hasler.JF .. The.Holstein.cow.in.embryo.transfer.today.as.compared.to.20.years.ago ..Theriogenology.2006;.65:4-16 .

Hatler TB, Hayes SH, Laranja da Fonseca LF, Silvia WJ ..Relationship.between.endogenous.progesterone.and.follicular.dynamics.in.lactating.dairy.cows.with.ovarian.follicular.cysts ..Biol.Reprod.2003;.69:218-223 ..

..Kelly.P,.Duffy.P,.Roche.JF,.Boland.MP .. Superovulation.in.cattle:.effect.of.FSH.type.and.method.of.administration.on.follicular.growth,.ovulatory.response.and.endocrine.patterns ..Anim.Reprod.Sci.1997;.46:1-14 ..

..Kulick.LJ,.Bergfelt.DR,.Kot.K,.Ginther.OJ ..Follicle.selection.in.cattle:.follicle.deviation.and.codominance.within.sequential.waves ..Biol.Reprod.2001;.65:839-846 ..

..Lammoglia.MA,.Short.RE,.Bellows.SE,.Bellows.RA,.MacNeil.MD,.et al .. Induced.and.synchronized.estrus.in.cattle:.dose.titration.of.estradiol.benzoate.in.peripubertal.heifers.and.postpartum.cows.after.treatment.with.an.intravaginal.progesterone-releasing.insert.and.prostaglandin.F2alpha ..J.Anim.Sci.1998;.76:1662-1670 .

..Leroy.JL,.Opsomer.G,.De.Vliegher.S,.Vanholder.T,.Goossens.L,.et al ..Comparison.of.embryo.quality.in.high-yielding.dairy.cows,.in.dairy.heifers.and.in.beef.cows ..Theriogenology.2005;.64:2022-2036 .

Lindsell CE, Rajkumar K, Manning A�, Emery SK, Mapletoft.RJ,.et al .. Variability.in.FSH:LH.ratios.among.batches.of.commercially.available.gonadotrophins ..Theriogenology.1986;.25:167-167 .

..Looney.CR,.Nelson.JS,.Schneider.HJ,.Forrest.DW ..Improving.fertility.in.beef.cow.recipients. .Theriogenology.2006;.65:201-209 ..

..Lynch. PR,. Macmillan. KL,. Taufa. VK .. Treating. cattle.with. progesterone. as . well. as . a. GnRH. analogue. affects.oestrous. cycle. length. and. fertility .. Anim. Reprod. Sci.1999;.56:189-200

.42 ..Martínez.AG,.Brogliatti.GM,.Valcarcel.A,.de.las.Heras.MA ..Pregnancy.rates.after.transfer.of.frozen.bovine.embryos: a field trial. Theriogenology 2002; 58:963-972.

..Medan.MS,.Takedom.T,.Aoyagi.Y,.Konishi.M,.Yazawa.S,.et al ..The.effect.of.active.immunization.against.inhibin.on.gonadotropin.secretions.and.follicular.dynamics.during.the.estrous.cycle.in.cows ..J.Reprod.Dev.2006;.52:107-113 .

..Mikkola.M,.Mantysaari.P,.Tammiranta.N,.Peippo.J,.Taponen.J ..Effect.of.dietary.protein.on.embryo.recovery.rate.and.quality.in.superovulated.heifers ..Anim.Reprod.Sci.2005;.87:193-202 .

Moraes C, Nogueira MF. SOV en ganado cebú de engorde: Protocolo.P-36 ..Congreso.internacional.de.reproducción.bovina ..Bogotá ..2005;.105-109 ..

..Munro.RK,.Moore.NW ..Effects.of.progesterone,.oestradiol.benzoate.and.cloprostenol.on.luteal.function.in.the.heifer ..J.Reprod.Fertil.1985;.73:353-359 ..

.. .Nogueira. MF,. Melo. DS,. Carvalho. LM,. Fuck. EJ,. Trinca.LA,.et al .. Do. high. progesterone. concentrations. decrease.pregnancy. rates. in . embryo. recipients. synchronized. with.PGF2alpha. and. eCG?. Theriogenology. 2004;. 61:1283-1290 ..

..Nowshari.MA,.Ali.SA ..Effect.of.season.and.gonadotropins.on.the.superovulatory.response.in.camel.(Camelus.dromedarius) ..Theriogenology.2005;.64:1526-1535 ..

..Rodger.LD,.Stormshak.F .. Gonadotropin-releasing.hormone-induced.alteration.of.bovine.corpus.luteum.function ..Biol.Reprod.1986;.35:149-156 .

..Rodríguez.L,.Giraldo.M,.Ruíz.ZT,.Valencia.L,.Andrade.JC,.et al .. Respuesta.superovulatoria.de.vacas.criollas.colombianas Blanco Orejinegro, BON, al tratamiento con FSH.o. PMSG:.informe.de.tres.casos ..Rev.Col.Cienc.Pec.1998;.11:16-26 ..

..Rodríguez.L,.Giraldo.M,.Vélez.MP,.Maldonado.JG ..Recuperación.y.transferencia.de.embriones.de.vacas.Holstein.de.élite.con.infecciones.uterinas.recurrentes ..Rev.Col.Cienc.Pec.1998;.11:61-71 ..

..Sartorelli.ES,.Carvalho.LM,.Bergfelt.DR,.Ginther.OJ,.Barros.CM ..Morphological.characterization.of.follicle.deviation.in.Nelore.(Bos.indicus).heifers.and.cows ..Theriogenology.2005;.63:2382-2394 ..

Sato T, Nakada K, Uchiyama Y, Kimura Y, Fujiwara N, et al .. The.effect.of.pretreatment.with.different.doses.of.GnRH.to.synchronize.follicular.wave.on.superstimulation.of.follicular.growth.in.dairy.cattle ..J. Reprod.Dev.2005;.51:573-578 .

..Savio.JD,.Thatcher.WW,.Morris.GR,.Entwistle.K,.Drost.M,.et al .. Effects.of.induction.of.low.plasma.progesterone.concentrations.with.a. progesterone-releasing.intravaginal.device.on.follicular.turnover.and.fertility.in.cattle ..J. Reprod.Fertil.1993;.98:77-84 ..

..Schrick.FN,.Inskeep.EK,.Butcher.RL ..Pregnancy.rates.for.embryos.transferred.from.early.postpartum.beef.cows.into.recipients.with.normal.estrous.cycles ..Biol.Reprod.1993;.49:617-621 ..

..Smith. GD,. Jackson. LM,. Foster. DL .. Leptin. regulation. of.reproductive. function. and. fertility .. Theriogenology. 2002;.57:73-86 .57 ..Spell.AR,.Beal.WE,.Corah.LR,.Lamb.GC ..Evaluating.recipient.and.embryo.factors.that.affect.pregnancy.rates.of.embryo.transfer.in.beef.cattle ..Theriogenology.2001;.56:287-297 .

..Stockman.MJ ..Ethics.of.embryo.transfer .. Vet.Rec.1985;.117:536 .

..Stringfellow.DA,.Givens.MD ..Epidemiologic.concerns.relative.to.in.vivo.and.in.vitro.production.of.livestock.embryos ..Anim.Reprod.Sci.2000;.60-61:629-642 .

..Stroud.B,.Hasler.JF .. Dissecting.why.superovulation.and.embryo.transfer.usually.work.on.some.farms.but.not.on.others ..Theriogenology.2006;.65:.65-76 .

..Todoroki.J, .Noguchi.J, .Kikuchi.K, .Kaneko.H .. Retrospective.analysis of the efficacy of controlled internal drug release in.follicular.cysts.in.an.embryo.donor.beef.herd ..J. Reprod.Dev.2004;.50:369-373 .

..Vasconcelos.JLM,.Demetrio.DGB,.Santos.RM,.Chiari.JR,.Rodriguez.CA,.et al. Factors.potentially.affecting.fertility.of.lactating.dairy.cow.recipients ..Theriogenology.2006;.65:192-200 .

..Walsh.JH,.Mantovani.R,.Duby.RT,.Overstrom.EW,.Dobrinsky.JR,.et al .. The.effects.of.once.or.twice.daily.injections of pFSH on superovulatory response in heifers. Theriogenology.1993;.40:.313-321 .

..Yaakub.H,.O’Callaghan.D,.Boland.MP ..Effect.of.type.and.quantity.of.concentrates.on.superovulation.and.embryo.yield.in.beef.heifers ..Theriogenology.1999;.51:1259-1266 .

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Published

2009-07-08

How to Cite

Maldonado Estrada, J. G., & Bolívar, P. A. (2009). Racionalidad de los esquemas de superovulación y sincronización en la transferencia de embriones en bovinos: ¿terapéutica basada en la evidencia o ausencia de ética?. Revista Colombiana De Ciencias Pecuarias, 21(3), 15. https://doi.org/10.17533/udea.rccp.324314

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