Factors associated with Mycobacterium avium subsp. paratuberculosis in dairy cows from Northern Antioquia, Colombia
Keywords:cattle, epidemiology, paratuberculosis, serology
Background: Johne´s disease (JD) is a severe enteritis that affects ruminants and has been diagnosed in cattle and sheep in Colombia. However, epidemiological information on the disease in this country is scarce. Objective: to identify factors associated with the JD serum enzyme-linked immunosorbent assay (ELISA) status of dairy cows. Methods: a cross-sectional study was carried out in 307 asymptomatic adult Holstein dairy cows from 14 herds in nine districts of Belmira and San Pedro de los Milagros municipalities during November, 2007. Nineteen to 29 cows, ≥ 2 years of age were randomly selected and blood sampled from every herd. A commercial ELISA kit was used to analyze sera. Information regarding cow related factors (age, farm-born, parity, and daily milk yield) and herd management practices (i.e. herd size, herd average milk production, current presence of symptomatic animals, cattle purchase, own animals grazing in foreign pastures, feeding of calves before weaning, manure spread on pastures, and sighting of birds in feed storing areas) was collected using questionnaires. Descriptive statistics were computed for all variables and a multivariable logistic regression model was constructed (p<0.05). Results: ten percent (31/307; 95% CI: 7-14%) of the animals were positive by ELISA. In 70% (10/14) of the herds, ELISA detected at least one positive animal. Cow and herd factors such as “parity” and “feeding of calves before weaning” showed weak and strong associations with ELISA positive results, respectively. The odds ratio (OR) for JD seropositivity increased 20% (OR = 1.20; 95% CI: 0.98-1.47; p = 0.067) in cows with > 1 parity. The OR was 0.74 times lower (OR = 0.26; 95% CI: 0.096-0.70; p<0.01) in herds feeding calves with pooled colostrum from several cows, compared to herds feeding calves with colostrum from their own dams. Conclusion: JD seroprevalence was 10 and 70% at animal and herd-level, respectively. Cow and herd factors “parity” and “feeding of calves before weaning” showed weak and strong association with positive results, respectively.
Ansari-Lari M, Haghkhah M, Bahramy A, Novin Baheran AM. Risk factors for Mycobacterium avium subspecies paratuberculosis in Fars province (Southern Iran) dairy herds. Trop Anim Health Prod 2009; 41(4):553-557.
Atreya R, Bülte M, Gerlach GF, Goethe R, Hornef MW, Köhler H, Meens J, Möbius P, Roeb E, Weiss S. Facts, myths and hypotheses on the zoonotic nature of Mycobacterium avium subspecies paratuberculosis. Int J Med Microbiol 2014; 304(7):858-867.
Barkema HW, Hesselink JW, McKenna SL, Benedictus G, Groenendaal H. Global Prevalence and Economics of Infection with Mycobacterium avium subsp. paratuberculosis in Ruminants. In: Behr MA, Collins DM (Eds.), Paratuberculosis: organism, disease, control. CAB International, Oxfordshire; 2010. pp. 10-17.
Beaudeau F, Belliard M, Joly A, Seegers H. Reduction in milk yield associated with Mycobacterium avium subspecies paratuberculosis(Map) infection in dairy cows. Vet Res 2007; 38(4):625-34.
Chacon O, Bermudez LE, Barletta RG. Johne’s disease, inflammatory bowel disease, and Mycobacteriumparatuberculosis .Annu Rev Microbiol 2004; 58:329-363.
Chiodini RJ, Van Kruiningen HJ, Merkal RS. Ruminant paratuberculosis (Johne’s disease): the current status and future prospects. Cornell Vet 1984; 74:218-262.
Collins MT, Sockett DC, Goodger WJ, Conrad TA, Thomas CB, Carr DJ. Herd prevalence and geographic distribution of, and risk factors for, bovine paratuberculosis in Wisconsin. J Am Vet Med Assoc 1994; 204(4):636-641.
Correa Valencia NM, Ramírez NF, Olivera M, Fernández Silva JA. Milk yield and lactation stage are associated with positive results to ELISA for Mycobacterium avium subsp. paratuberculosis in dairy cows from Northern Antioquia, Colombia: a preliminary study. Trop Anim Health Prod 2016, 48(6):1191-1200.
Dieguez FJ, Arnaiz I, Sanjuan ML, Vilar MJ, Yus, E. Management practices associated with Mycobacteriumavium subspecies paratuberculosis infection and the effects of the infection on dairy herds. Vet Rec 2008; 162(19):614-617.
Dohoo I, Martin W, Stryhn H. Model-building strategies 365-394. In: Dohoo I, Martin W, Stryhn H (Eds). Veterinary Research Epidemiology. 2nd edition. Charlottetown: VER Inc. 2009. 865 p.
Fernández-Silva JA, Correa-Valencia NM, Ramírez NF. Systematic review of the prevalence of paratuberculosis in cattle, sheep, and goats in Latin America and the Caribbean. Trop Anim Health Prod 2014; 46(8):1321-1340.
Fredriksen B, Djonne B, Sigurdardottir O, Tharaldsen J, Nyberg O, Jarp J. Factors affecting the herd level of antibodies against Mycobacteriumavium subspecies paratuberculosis in dairy cattle. Vet Rec 2004; 154(17):522-526.
Gonda MG, Chang YM, Shook GE, Collins MT, Kirkpatrick BW. Effect of Mycobacterium paratuberculosis infection on production, reproduction, and health traits in US Holsteins. Prev Vet Med 2007; 80(2-3):103-119.
Goodger WJ, Collins MT, Nordlund KV, Eisele C, Pelletier J, Thomas CB, Sockett DC. Epidemiologic study of on-farm management practices associated with prevalence of Mycobacterium paratuberculosis infections in dairy cattle. J Am Vet Med Assoc 1996; 208:1877-1881.
Grewal SK, Rajeev S, Sreevatsan S, Michel FC Jr. Persistence of Mycobacteriumavium subsp. paratuberculosis and other zoonotic pathogens during simulated composting, manure packing, and liquid storage of dairy manure. Appl Environ Microbiol 2006; 72(1):565-574.
Hacker U, Huttner K, Konow M. Investigation of serological prevalence and risk factors of paratuberculosis in dairy farms in the state of Mecklenburg-Westpommerania, Germany. Berl Munch Tierarztl Wochenschr 2004; 117(3-4):140-144.
Harris NB, Barletta RG. Mycobacterium avium subsp. paratuberculosis in Veterinary Medicine. Clin Microbiol Rev 2001; 14:489-512.
Jakobsen MB, Alban L, Nielsen SS. A cross-sectional study of paratuberculosis in 1155 Danish dairy cows. Prev Vet Med 2000; 46(1):15-27.
Jenvey CJ, Reichel MP, Cockcroft PD. The diagnostic performance of an antibody enzyme-linked immunosorbent assay using serum and colostrum to determine the disease status of a Jersey dairy herd infected with Mycobacterium avium subspecies paratuberculosis. J Vet Diagn Invest 2016; 28(1):50-53.
Johnson YJ, Kaneene JB, Gardiner JC, Lloyd JW, Sprecher DJ, Coe PH. The effect of subclinical Mycobacterium paratuberculosis infection on milk production in Michigan dairy cows. J Dairy Sci 2001; 84(10):2188-2194.
Johnson-Ifearulundu Y, Kaneene JB. Distribution and environmental risk factors for paratuberculosis in dairy cattle herds in Michigan. Am J Vet Res 1999; 60(5):589-596.
Jorgensen JB. Survival of Mycobacteriumparatuberculosis in slurry,” Nord Vet Med 1977; 29(6): 26-70.
Kobayashi S, Tsutsui T, Yamamoto T, Nishiguchi A. Epidemiologic indicators associated with within-farm spread of Johne’s disease in dairy farms in Japan. J Vet Med Sci 2007; 69(12):1255-1258.
Kudahl A, Nielsen SS, Sørensen JT. Relationship between antibodies against Mycobacterium avium subsp. paratuberculosis in milk and shape of lactation curves. Prev Vet Med 2004; 62(2):119-134.
Laurin E, McKenna S, Chaffer M, Keefe G. Sensitivity of solid culture, broth culture, and real-time PCR assays for milk and colostrum samples from Mycobacterium avium ssp. paratuberculosis-infectious dairy cows. J Dairy Sci 2015; 98(12):8597-8609.
Manning JB, Collins MT. Epidemiology of paratuberculosis. In Behr MA and Collins DM (eds.) Paratuberculosis: organism, disease, control Oxfordshire: CAB International, 2010, pp. 22-27.
McAloon CG, Whyte P, More SJ, Green MJ, O’Grady L, Garcia A, Doherty ML. The effect of paratuberculosis on milk yield-A systematic review and meta-analysis. J Dairy Sci 2016; 99(2):1449-1460.
Nielsen SS, Toft N. A review of prevalences of paratuberculosis in farmed animals in Europe. Prev Vet Med 2009; 88:1-14.
Nielsen SS, Toft N. Effect of management practices on paratuberculosis prevalence in Danish dairy herds. J Dairy Sci 2011; 94(4):1849-1857.
Nielsen SS, Bjerre H, Toft, N. Colostrum and milk as risk factors for infection with Mycobacteriumavium subspecies paratuberculosis in dairy cattle. J Dairy Sci 2008; 91(12):4610-5.
Nielsen SS, Enevoldsen C, Grohn YT. The Mycobacteriumaviumsubsp. paratuberculosis ELISA response by parity and stage of lactation. Prev Vet Med 2002; 54(1):1-10.
Obasanjo IO, Grohn YT, Mohammed HO. Farm factors associated with the presence of Mycobacteriumparatuberculosis infection in dairy herds on the New York State Paratuberculosis Control Program. Prev Vet Med 1997; 32(3-4):243-251.
Pieper L, Sorge US, DeVries T, Godkin A, Lissemore K, Kelton D. Comparing ELISA test-positive prevalence, risk factors and management recommendations for Johne’s disease prevention between organic and conventional dairy farms in Ontario, Canada. Prev Vet Med 2015; 122(1-2):83-91.
Pithua P, Wells SJ, Godden SM, Stabel JR. Evaluation of the association between fecal excretion of Mycobacterium aviumsubsp paratuberculosis and detection in colostrum and on teat skin surfaces of dairy cows. J Am Vet Med Assoc 2011; 238(1):94-100.
Ramírez N, Rodriguez B, Fernandez SJ. Diagnóstico clínico e histopatológico de paratuberculosis bovina en un hato lechero en Colombia. Rev MVZ Córdoba 2011; 16:2742-2753.
Richardson E, More S. Direct and indirect effects of Johne‘s disease on farm and animal productivity in an Irish dairy herd. Ir Vet J 2009; 62(8):526-532.
Sechi LA, Dow CT. Mycobacterium avium ss. paratuberculosisZoonosis - the hundred year war - beyond Crohn’s disease. Front Immunol 2015; 6:96.
Sorge US, Lissemore K, Godkin A, Jansen J, Hendrick S, Wells S, Kelton DF. Risk factors for herds to test positive for Mycobacterium avium ssp. paratuberculosis-antibodies with a commercial milk enzyme-linked immunosorbent assay (ELISA) in Ontario and western Canada. Can Vet J 2012; 53(9):963-970.
Stabel JR, Bradner L, Robbe-Austerman S, Beitz DC. Clinical disease and stage of lactation influence shedding of Mycobacterium avium subspecies paratuberculosis into milk and colostrum of naturally infected dairy cows. J Dairy Sci 2014; 97(10):6296-6304.
Streeter RN, Hoffsis GF, Bech-Nielsen S, Shulaw WP, Rings DM. Isolation of Mycobacteriumparatuberculosis from colostrum and milk of subclinically infected cows. Am.J Vet Res 1995; 56(10): 1322-1324.
Sweeney RW. Transmission of paratuberculosis. Vet Clin North Am Food Anim Pract 1996; 12:305-12.
Tiwari A, VanLeeuwen JA, Dohoo IR, Keefe GP, Haddad JP, Scott HM, Whiting T. Risk factors associated with Mycobacterium avium subspecies paratuberculosis seropositivity in Canadian dairy cows and herds. Prev Vet Med 2009; 88:32-41.
Vilar AL, Santos CS, Pimenta CL, Freitas TD, Brasil AW, Clementino IJ, Alves CJ, Bezerra CS, Riet-Correa F, Oliveira TS, Azevedo SS. Herd-level prevalence and associated risk factors for Mycobacterium avium subsp. paratuberculosis in cattle in the State of Paraíba, Northeastern Brazil. Prev Vet Med 2015; 121(1-2):49-55.
Weber MF. Risk management of paratuberculosis in dairy herds. Ir Vet J 2006; 9(10):555-561.
Wells SJ, Wagner BA. Herd-level risk factors for infection with Mycobacteriumparatuberculosis in US dairies and association between familiarity of the herd manager with the disease or prior diagnosis of the disease in that herd and use of preventive measures. J Am Vet Med Assoc 2000; 216(9):1450-1457.
Zapata M, Arroyave O, Ramirez R, Piedrahita C, Rodas JD, Maldonado JG. Identification of Mycobacteriumavium subspecies paratuberculosis by PCR techniques and establishment of control programs for bovine paratuberculosis in dairy herds. Rev Colomb Cienc Pecu 2010; 23:17-27.
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