Adenoma of the pars intermedia of the pituitary gland in a horse in Colombia, morphological and immunohistochemical study: case report
DOI:
https://doi.org/10.17533/udea.rccp.e358032Keywords:
ACTH, Argentine saddle horse, Colombia, equine, gelded male, neoplasia, pituitaryAbstract
Anamnesis: An Argentine saddle horse with poor body condition, general weakness, and recurrent pathological decubitus without response to treatment was euthanized and subjected to diagnosis. Clinical and laboratory findings: At necropsy, hirsutism, and poor body condition were observed. The pituitary gland protruded from the sella turcica and measured 2.3 cm thick and 2.8 cm high. A nodule measuring 1.3 cm in diameter was observed in the middle part of the pituitary gland. Histological findings revealed an adenoma in the pars intermedia of the pituitary gland. The neoplastic cells were immunoreactive for ACTH, and the markers for PRL, NSE, and GFAP were negative. The ultrastructure of the neoplastic cells showed intracytoplasmic granules of variable electron density and diameters between 160 and 250 nm. Conclusion: This is the first report of a pars intermedia adenoma in an Argentine saddle horse and the first comprehensive diagnosis of this neoplasia in Colombia and South America.
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