Copper-Zinc serum traces, physical activity and geriatric depression in older adults: a cross-sectional study

Autores/as

  • Jean Carlos Zambrano Universidad de Los Andes https://orcid.org/0000-0002-4536-9077
  • Ramón A. Marquina Universidad de los Andes
  • María V. Gómez
  • Edyleiba Rojas
  • Rithard L. Bolívar
  • Eduvigis Solórzano Universidad de las Andes
  • Carlos E. Rondón Universidad de los Andes
  • Rafael A. Reyes-Alvarez Universidad de los Andes
  • Thairy G. Reyes-Valero NOVA Southeastern University, Fort Lauderdae, Florida

Palabras clave:

Copper-Zinc, Serum traces, Geriatric depression, Physical activity

Resumen

Aim: to evaluate serum levels of copper and zinc and to investigate the association between copper-to-zinc (Cu/Zn) ratios and age, self-reported depression, and physical exercise in a sample of adults aged 60 to 92 years. Methods and materials: 101 participants without prior cardiovascular disease were enrolled. Anthropometric measurements were taken, and blood samples were collected from the left arm. Serum copper and zinc levels were measured by atomic absorption spectroscopy, and Cu/Zn ratios were calculated by absorbance and colorimetric tests. Geriatric depression was assessed using the Yesavage scale index (GDS-15). Statistical analyses included chi-square tests and logistic regression models with a significance level of 5%. Results: of the 101 participants, 54 were physically active (i.e., engaged in at least 60 minutes of exercise, three times per week) with an average age of 67.5 ± 7.8 years, while 47 were sedentary with an average age of 74.8 ± 9.1 years. The results showed a high prevalence of Cu-Zn deficiency and alterations in Cu/Zn ratios in older adults and those with low physical activity. Multivariate analysis revealed an association between Cu/Zn ratios and physical exercise and age. Physical exercise was found to be a protective factor (odds ratio [OR] = 0.086; 95% confidence interval [CI]: 0.021-0.348; p < 0.001), while age was a risk factor (OR = 1.062; 95% CI: 1.005-1.123; p < 0.034) for high Cu/Zn ratios (≥2). Conclusion: in populations with a high prevalence of copper and zinc deficiencies, Cu/Zn ratios appear to be independent of nutritional parameters and more strongly associated with age and physical exercise.

|Resumen
= 34 veces | PDF (ENGLISH)
= 14 veces|

Descargas

Los datos de descargas todavía no están disponibles.

Biografía del autor/a

Jean Carlos Zambrano, Universidad de Los Andes

Doctorate in Physical Activity and Sport Sciences

Ramón A. Marquina, Universidad de los Andes

Doctorate in Physical Activity and Sport Sciences

Citas

Acosta García, E., Galdona, E., Barón, M. A., Páez, M. C., Velásquez, E., & Solano, L. (2010). Zinc y cobre séricos y la relación zinc/cobre en un grupo de niños del sur de Valencia, Venezuela. Acta Bioquímica Clínica Latinoamericana, 44(1), 295-297. https://www.scielo.org.ar/scielo.php?pid=S0325-29572010000100004&script=sci_arttext

Alghadir, A. H., Gabr, S.A., & Al-Eisa, E. S. (2015). Assessment of the effects of glutamic acid decarboxylase antibodies and trace elements on cognitive performance in older adults. Clinical Interventions in Aging, 10, 1901. https://doi.org/10.2147/CIA.S95974

Anagnostis, P., Stevenson, J. C., Crook, D., Johnston, D. G., & Godsland, I. F. (2015). Effects of menopause, gender and age on lipids and high-density lipoprotein cholesterol subfractions. Maturitas, 81(1), 62-68. https://doi.org/10.1016/j.maturitas.2015.02.262

Arik, G., Varan, H. D., Yavuz, B. B., Karabulut, E., Kara, O., Kilic, M. K., Kizilarslanoglu, M. C., Sumer, F., Kuyumcu, M. E., Yesil, Y., Halil, M., & Cankurtaran, M. (2015). Validation of Katz index of independence in activities of daily living in Turkish older adults. Archives of Gerontology and Geriatrics, 61(3), 344-350. https://doi.org/10.1016/J.ARCHGER.2015.08.019

Bahi, G. A., Boyvin, L., Méité, S., M’Boh, G. M., Yeo, K., N’Guessan, K. R., Bidié, A. D. P., & Djaman, A. J. (2017). Assessments of serum copper and zinc concentration, and the Cu/Zn ratio determination in patients with multidrug resistant pulmonary tuberculosis (MDR-TB) in Côte d’Ivoire. BMC Infectious Diseases, 17(1), 1-6. https://doi.org/10.1186/s12879-017-2343-7

Brewer, G. J., & Kaur, S. (2013). Zinc deficiency and Zinc therapy efficacy with reduction of Serum Free Copper in Alzheimer’s Disease. International Journal of Alzheimer’s Disease, 2013, 1–4. https://doi.org/10.1155/2013/586365

Campesi, I., Occhioni, S., Tonolo, G., Cherchi, S., Basili, S., Carru, C., Zinellu, A., & Franconi, F. (2016). Ageing/menopausal status in healthy women and ageing in healthy men differently affect cardiometabolic parameters. International Journal of Medical Sciences, 13(2), 124–132. https://doi.org/10.7150/ijms.14163

Choudhary, P. (2017). Study of micro-nutrients status and anthopometric measurementsin postmenopausal women. International Journal of Scientific Research, 6(3), 4-6. https://shorturl.at/NdlkV

Cousins, R. J. (1985). Absorption, transport, and hepatic metabolism of copper and zinc: Special reference to metallothionein and ceruloplasmin. Physiological Reviews, 65(2), 238-309. https://doi.org/10.1152/physrev.1985.65.2.238

Galeoto, G., Sansoni, J., Scuccimarri, M., Bruni, V., De Santis, R., Colucci, M., Valente, D., & Tofani, M. (2018). A Psychometric properties evaluation of the Italian version of the Geriatric Depression Scale. Depression Research and Treatment, 2018, 1-7. https://doi.org/10.1155/2018/1797536

Gernand, A. D., Schulze, K. J., Stewart, C. P., West, K. P., & Christian, P. (2016). Micronutrient deficiencies in pregnancy worldwide: health effects and prevention. Nature Reviews Endocrinology, 12(5), 274-289. https://doi.org/10.1038/nrendo.2016.37

Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Rink, L., Mariani, E., Fulop, T., Dedoussis, G., Herbein, G., & Provinciali, M. (2017). Main biomarkers associated with age-related plasma zinc decrease and copper/zinc ratio in healthy elderly from ZincAge study. European Journal of Nutrition, 56(8), 2457-2466. https://10.1007/s00394-016-1281-2

Harrison., & Kasper, D. L. (2015). Principios de medicina interna. McGraw-Hill.

Kloubert, V., & Rink, L. (2015). Zinc as a micronutrient and its preventive role of oxidative damage in cells. Food & Function, 6(10), 3195-3204. https://doi.org/10.1039/c5fo00630a

Malavolta, M., Giacconi, R., Piacenza, F., Santarelli, L., Cipriano, C., Costarelli, L., Tesei, S., Pierpaoli, S., Basso, A., Galeazzi, R., Lattanzio, F., & Mocchegiani, E. (2010a). Plasma copper/zinc ratio: an inflammatory/nutritional biomarker as predictor of all-cause mortality in elderly population. Biogerontology, 11(3), 309-319.

https://doi.org/10.1007/s10522-009-9251-1

Malavolta, M., Piacenza, F., Basso, A., Giacconi, R., Costarelli, L., & Mocchegiani, E. (2015a). Serum copper to zinc ratio: Relationship with aging and health status. Mechanisms of Ageing and Development, 151, 93-100. https://doi.org/10.1016/j.mad.2015.01.004

Meertens de R., L., Ramos, N., Solano R., L., Llovera, D., Portillo, Z. (2005). Serum Zinc and CD4 and CD8 lymphocyte subpopulations in institutionalized elderly. Acta Científica Venezolana, 56(3), 120-125.

Mocchegiani, E., Malavolta, M., Lattanzio, F., Piacenza, F., Basso, A., Abbatecola, A. M., Russo, A., Giovannini, S., Capoluongo, E., Bustacchini, S., Guffanti, E. E., Bernabei, R., & Landi, F. (2012). Cu to Zn ratio, physical function, disability, and mortality risk in older elderly (ilSIRENTE study). Age, 34(3), 539-552. https://doi.org/10.1007/s11357-011-9252-2

Olivares, M., Lera, L., Albala, C., Pizarro, F., & Araya, M. (2011). Prevalence of zinc and copper deficiencies in older subjects living in Metropolitan Santiago. Revista Médica de Chile, 139(3), 283-289. https://doi.org//S0034-98872011000300001

Prasad, A. S. (2009). Impact of the discovery of human zinc deficiency on health. Journal of the American College of Nutrition, 28(3), 257-265. https://doi.org/10.1016/j.jtemb.2014.09.002

Ranasinghe, P., Wathurapatha, W., Ishara, M., Jayawardana, R., Galappatthy, P., Katulanda, P., & Constantine, G. (2015). Effects of Zinc supplementation on serum lipids: a systematic review and meta-analysis. Nutrition & Metabolism, 12(1), 26.

https://doi.org/10.1186/s12986-015-0023-4

Saravanabhavan, G., Werry, K., Walker, M., Haines, D., Malowany, M., & Khoury, C. (2017). Human biomonitoring reference values for metals and trace elements in blood and urine derived from the Canadian Health Measures Survey 2007-2013. International Journal of Hygiene and Environmental Health, 220(2), 189-200. https://doi.org/10.1016/j.ijheh.2016.10.006

Speich, M., Pineau, A., & Ballereau, F. (2001). Minerals, trace elements and related biological variables in athletes and during physical activity. Clinica Chimica Acta, 312(1-2), 1-11. https://doi.org/10.1016/S0009-8981(01)00598-8

Spss, I. (2011). IBM SPSS statistics for Windows, version 20.0. New York: IBM Corp, 440, 394.

Stafford, S. L., Bokil, N. J., Achard, M. E. S., Kapetanovic, R., Schembri, M. A., McEwan, A. G., & Sweet, M. J. (2013). Metal ions in macrophage antimicrobial pathways: Emerging roles for zinc and copper. Bioscience Reports, 33(4), 541-554. https://doi.org/10.1042/BSR20130014

Wani, A. L., Parveen, N., Ansari, M. O., Ahmad, Md. F., Jameel, S., & Shadab, G. G. H. A. (2017). Zinc: An element of extensive medical importance. Current Medicine Research and Practice, 7(3), 90-98. https://doi.org/10.1016/j.cmrp.2017.02.006

Yanagisawa, H., Kawashima, T., Miyazawa, M., & Ohshiro, T. (2016). Validity of the copper/zinc ratio as a diagnostic marker for taste disorders associated with zinc deficiency. Journal of Trace Elements in Medicine and Biology, 36, 80-83. https://doi.org/10.1016/j.jtemb.2016.04.012

Descargas

Publicado

2024-10-18

Cómo citar

Zambrano, J. C., Marquina, R. A., Gómez, M. V., Rojas, E., Bolívar, R. L., Solórzano, E., Rondón, C. E., Reyes-Alvarez, R. A., & Reyes-Valero, T. G. (2024). Copper-Zinc serum traces, physical activity and geriatric depression in older adults: a cross-sectional study. VIREF Revista De Educación Física, 13(3), 37–49. Recuperado a partir de https://revistas.udea.edu.co/index.php/viref/article/view/353623

Número

Vol. 13 Núm. 3 (2024): Vol. 13 Núm. 3 (2024)

Sección

Informe de investigación

Licencia

Aquellos autores/as que tengan publicaciones con esta revista, aceptan los términos siguientes:

  1. Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, el cuál estará simultáneamente sujeto a la Licencia de reconocimiento de Creative Commons que permite a terceros compartir la obra siempre que se indique su autor y su primera publicación esta revista.
  2. Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la publicación inicial en esta revista.
  3. Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en archivos telemáticos institucionales o en su página web) antes y durante el proceso de envío, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada. (Véase El efecto del acceso abierto).

Licencia Creative Commons

Licencia Creative Commons

VIREF Revista de Educación Física se encuentra bajo Licencia Creative Commons: Atribución No Comercial Compartir Igual