Factores genéticos y epigenéticos del cáncer gástrico

Autores/as

  • Tania Pérez - Cala Universidad de Antioquia https://orcid.org/0000-0001-5095-3289
  • Mauricio Camargo Universidad de Antioquia
  • Alonso Martínez Grupo Bacterias, Universidad de Antioquia

DOI:

https://doi.org/10.17533/udea.acbi.v39n106a01

Palabras clave:

cáncer gástrico, genes supresores de tumor, genética, metilación, oncogenes

Resumen


El cáncer gástrico (CG) es la primera causa de muerte por cáncer en Colombia, la tumorogénesis gástrica es un proceso gradual y de larga evolución que incluye cambios genéticos y epigenéticos que activan protooncogenes e inactivan genes supresores de tumor (GST). Los cambios genéticos incluyen pérdida de heterocigocidad (LOH), inestabilidad microsatelital (MSI), translocaciones, aneuploidía, y mutaciones en GST; y amplificaciones o mutaciones en protooncogenes. Por otro lado, la alteración epigenética más frecuente es la metilación de los promotores. En la actualidad, el CG es un problema de salud pública en Colombia por tres factores: las altas tasas de incidencia/mortalidad, los sobrecostos de los tratamientos de la enfermedad en estadios avanzado y la falta de acceso de la población a los servicios de salud. Esta revisión expondrá las alteraciones genéticas y epigenéticas que se encuentran con mayor frecuencia en CG, y su asociación con los diferentes tipos de CG.

|Resumen
= 249 veces | PDF
= 149 veces| | HTML
= 116 veces|

Descargas

Los datos de descargas todavía no están disponibles.

Citas

Adrada J, Calambás F, Díaz J, Delgado D, Sierra C. 2008. Características sociodemográficas y clínicas en una población con cáncer gástrico en el departmento de Cauca, Colombia. Revista Colombiana de Gastroenterología, 23: 309-314.

Al-Moundhri M, Al-Nabhani M, Tarantini L, Baccarelli A, Rusiecki J. 2010. The prognostic significance of whole blood global and specific DNA methylation levels in gastric adenocarcinoma. Public Library of Science one [Internet], 5 (12): e15585. Fecha de acceso: 14 de enero de 2013. Disponible en <http://journals.plos.org/plosone/articleid=10.1371/journal.pone.0015585>

Altucci L, Gronemeyer H. 2001. The promise of retinoids to fight against cancer. Nature Reviews Cancer, 1 (3): 181-193.

American Cancer Society [Internet]. 2012. Cáncer de estómago: guía detallada. Fecha de acceso: 11 de enero de 2014. Disponible en: http://www.cancer.org/Espanol/cancer/Cancerdeestomago/Guiadetallada/index>.

Andrés G, Ashour N, Sánchez-Chapado M, Ropero S, Angulo J. 2013. The study of DNA methylation in urological cancer: present and future. Actas Urologicas Españolas, 37 (6): 368-75.

Arafa M, Kridelka F, Mathias V, Vanbellinghen J, Renard I, Foidart J, Boniver J, Delvenne P. 2008. High frequency of RASSF1A and RARb2 gene promoter methylation in morphologically normal endometrium adjacent to endometrioid adenocarcinoma. Histopathology, 53 (5): 525-532.

Arango L, Giraldo A, Pardo C. 2008. Tasa de mortalidad por cánceres

del tubo digestivo según género y grupos de edad en Colombia entre 1980 y 1998. Revista Colombiana de Gastroenterologia, 23 (12): 124-135.

Araya J, Roa J, Villaseca M, Roa I, Guzmán P, Alvarado C. 2003. Mutación puntual del gen supresor de tumores TP53 en lesiones preneoplásicas y neoplásicas del estómago: cross-sectional study in a high risk region. Revista Médica de Chile, 131: 359-365.

Balassiano K, Lima S, Jenab M, Overvad K, Tjonneland A, Boutron Ruault MC, Clavel-Chapelon F, Canzian F, Kaaks R, Boeing H, Meidtner K, Trichopoulou A, Laglou P, Vineis P, Panico S, Palli D, Grioni S, Tumino R, Lund E, Bueno-de-Mesquita HB, Numans ME, Peeters PH, Ramon Quirós J, Sánchez MJ, Navarro C, Ardanaz E, Dorronsoro M, Hallmans G, Stenling R, Ehrnström R, Regner S, Allen NE, Travis RC, Khaw KT, Offerhaus GJ, Sala N, Riboli E, Hainaut P, Scoazec JY, Sylla BS, Gonzalez CA, Herceg Z. 2011. Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Cancer Letters, 311 (1): 85-95.

Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, Lordick F, Ohtsu A, Omuro Y, Satoh T, Aprile G, Kulikov E, Hill J, Lehle M, Rüschoff J, Kang YK, ToGA Trial Investigators. 2010. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet, 376 (9742): 687-97.

Barber M, Murrell A, Ito Y, Maia AT, Hyland S, Oliveira C, Save V, Carneiro F, Paterson AL, Grehan N, Dwerryhouse S, Lao-Sirieix P, Caldas C, Fitzgerald RC.. 2008. Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer. The Journal of Pathology, 216: 295-306.

Barnes LD, Garrison PN, Siprashvili Z, Guranowski A, Robinson A, Ingram S, Croce C, Ohta M, Huebner K. 1996. Fhit, a putative tumor suppressor in humans, is a dinucleoside 5’,5 ‘-P1,P3- triphosphate hydrolase. Biochemistry, 35 (36): 11529-35.

Baylin S, Jones P. 2011. A decade of exploring the cancer epigenome

— biological and translational implications. Nature Reviews Cancer, 11 (10): 726-734.

Benchabane H, Ahmed Y. 2009. The adenomatous polyposis coli tumor suppressor and Wnt signaling in the regulation of apoptosis. Advances in Experimental Medicine and Biology, 1 (656): 75-84.

Bernal C, Vargas M, Ossandón F, Santibáñez E, Urrutia J, Luengo V, Zavala L, Backhouse C, Palma M, Argandoña J, Aguayo F, Corvalán A. 2008. DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis. Biological Research, 41 (3): 303-15.

Boland C, Sung K, Ajay G. 2009. Promoter methylation in the genesis of gastrointestinal cancer. Yonsei Medical Journal, 50 (3): 309-21.

Byun S, Min-goo G, Kwon-seok S, Byung-gyu G, Sung-gil G. 2001. Frequent epigenetic inactivation of RASSF1A by aberrant promoter hypermethylation in human gastric adenocarcinoma. Cancer Research, 61 (19): 7034-7038.

Calcagno DQ, Guimarães AC, Leal MF, Seabra AD, Khayat AS, Pontes

TB, Assumpção PP, De Arruda SM, Burbano RR. 2009. MYC insertions in diffuse-type gastric adenocarcinoma. Anticancer Research, 29 (7) 2479-83.

Calcagno DQ, Leal MF, Demachki S, Araújo MT, Freitas FW, Oliveira e Souza D, Assumpção PP, Ishak G, de Arruda Cardoso Smith M, Burbano RR. 2010. MYC in gastric carcinoma and intestinal metaplasia of young adults. Cancer Genetics and Cytogenetics, 202 (1): 63-6.

Calcagno DQ, Leal MF, Seabra AD, Khayat AS, Chen ES, Demachki S,

Assumpção PP, Faria MH, Rabenhorst SH, Ferreira MV, de Arruda SM, Burbano RR. 2006. Interrelationship between chromosome 8 aneuploidy, C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma.

World Journal of Gastroenterology, 12 (38): 6207-11.

Cañas M, Morán Y, Camargo ME, Rivero M, Bohórquez A, Villegas V, Ramírez E, Rendón Y, Suárez A, Morales L, Useche E, Salazar S, Zambrano A, Ramírez A, Valderrama E, Briceño Z, Chiurillo MA. 2009. TP53 codon 72 polymorphism and gastric cancer risk: a case-control study in individuals from the central-western region of Venezuela. Investigación Clínica, 50 (2): 153-61.

Cancer National Institute [Internet] 2012. What is Cancer? Cancer National Institute. National Institute of Health. Fecha de acceso: 11 de enero de 2013. Disponible en: < http://www.cancer.gov/about-cancer/what-is-cancer>

Capuzzi D, Santoro E, Hauck W, Kovatich A, Rosato F, Baffa R, Huebner K, McCue PA. 2000. Fhit expression in gastric adenocarcinoma: correlation with disease stage and survival. Cancer, 88 (1): 24-34.

Cavallo F, Giovanni C, Nanni P, Forni G, Lollini PL. 2011. The immune hallmarks of cancer. Cell, 60 (3): 319-326.

Chen, Y, Tang Q, Shen-quan Z. 2005. Inactivation of RASSF1A, the tumor suppressor gene at 3p21.3 in extrahepatic cholangiocarcinoma. World Journal of Gastroenterology, 11 (9): 1333-1338.

Choi CH, Lee KM, Choi JJ, Kim TJ, Kim WY, Lee JW, Lee SJ, Lee JH, Bae DS, Kim BG. 2007. Hypermethylation and loss of heterozygosity of tumor suppressor genes on chromosome 3p in cervical cancer. Cancer Letters, 255 (1): 26-33.

Correa, P. 1984. Chronic gastritis as a cancer precursor. Scand J Gastroenterol Suppl, 104: 131-136.

Correa P, Haenszel W, Cuello C, Tannenbaum S, Archer M. 1975. A model for gastric cancer epidemiology. Lancet, 2 (7924): 58-60.

Correa P, Shiao YH. 1994. Phenotypic and genotypic events in gastric carcinogenesis. Cancer Research, 54 (7 Suppl): 1941s-1943s.

Correa, P. 1992. Human Gastric Carcinogenesis: A Multistep and

Multifactorial Process First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Research, 52 (24): 6735-6740.

Corso G, Seruca R, Roviello F. 2012. Gastric cancer carcinogenesis and tumor progression. Annali Italiani di Chirurgia, 83(3): 172-176.

Dang HZ, Yu Y, Jiao SC. 2012. Prognosis of HER2 over-expressing gastric cancer patients with liver metastasis. World Journal of Gastroenterology, 18 (19): 2402-7.

De Moura CV, Azevedo E, de Moraes E, Olivier M, Hainaut P. 2005. TP53 mutations as biomarkers for cancer epidemiology in Latin America: current knowledge and perspectives. Mutation Research, 589 (3): 192-207

de Souza CR, Leal MF, Calcagno DQ, Costa Sozinho EK, Borges Bdo N, Montenegro RC, Dos Santos AK, Dos Santos SE, Ribeiro HF, Assumpção PP, de Arruda Cardoso Smith M, Burbano RR. 2013. MYC deregulation in gastric cancer and its clinicopathological implications. Public Library of Science one [Internet], 8 (5): e64420. Fecha de acceso: 14 de enero de 2013. Disponible en:<http://journals.plos.org/plosone/article?id=10.1371/journal.

pone.0064420>

De Vita F, Giuliani F, Silvestris N, Catalano G, Ciardiello F, Orditura

M. 2010. Human epidermal growth factor receptor 2 (HER2) in gastric cancer: a new therapeutic target. Cancer Treatment Reviews, 36 (Suppl 3): S11-5.

Donninger H, Vos MD, Clark GJ. 2007. The RASSF1A tumor suppressor. Journal of Cell Science, 120: 3163-3172.

Druck T, Berk L, Huebner K. 1998. FHITness and cancer. Oncology Research, 10 (7): 341-5.

Druck T, Hadaczek, Fu PT, Ohta M, Siprashvili Z, Baffa R, Negrini

M, Kastury K, Veronese ML, Rosen D, Rothstein J, McCue P, Cotticelli MG, Inoue H, Croce CM, Huebner K. 1997. Structure and expression of the human FHIT gene in normal and tumor cells. Cancer Research, 57 (3): 504-12.

Duan XM, Zhang GY, Wu ES. 2000. Abnormal expression of the FHIT gene in human primary gastrointestinal cancers. Bulletin of Hunan Medical University, 25 (4): 331-3.

Fang DC, Luo YH, Yang SM, Li XA, Ling XL, Fang L. 2002. Mutation

analysis of APC gene in gastric cancer with microsatellite instability. World Journal of Gastroenterology, 8 (5): 787-791.

Fendri A, Masmoudi A, Khabir A, Sellami-Boudawara T, Daoud J, Frikha M, Ghorbel A, Gargouri A, Mokdad-Gargouri R. 2009. Inactivation of RASSF1A, RARbeta2 and DAP-kinase by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma. Cancer Biology & Therapy, 8 (5): 444-51.

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M,

Parkin DM, Forman D, Bray F. 2015. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer, 36(5):59-86.

Gao J1, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, Cerami E, Sander C, Schultz N. 2013. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Science Signaling, 6 (269): 11.

García P, Manterola C, Araya JC, Villaseca M, Guzmán P, Sanhueza A, Thomas M, Alvarez H, Roa JC. 2009. Promoter methylation profile in preneoplastic and neoplastic gallbladder lesions. Molecular Carcinogenesis, 48 (1): 79-89.

Garziera M, Canzonieri V, Cannizzaro R, Geremia S, Caggiari L, De

Zorzi M, Maiero S, Orzes E, Perin T, Zanussi S, De Paoli P, De Re V. 2013. Identification and characterization of CDH1 germline variants in sporadic gastric cancer patients and in individuals at risk of gastric cancer. Public Library of Science one [Internet], 8(10): e77035. Fecha de acceso: 14 de enero de 2013. Disponible en: <http://journals.plos.org/plosone/article?id=10.1371/journal.

pone.0077035>

Gemma A, Hagiwara K, Ke Y, Burke LM, Khan MA, Nagashima M,

Bennett WP, Harris CC. 1997. FHIT mutations in human primary

gastric cancer. Cancer Research, 57 (8): 1435-7.

Georgopoulos NT, Kirkwood LA, Walker DC, Southgate J. 2010. Differential regulation of growth-promoting signalling pathways by E-cadherin. Public Library of Science one [Internet], 5 (10): e13621. Fecha de acceso: 14 de enero de 2014. Disponible en: <http://journals.plos.org/plosone/article?id=10.1371/journal.

pone.0013621>

Goel A, Nagasaka T, Arnold C, Inoue T, Hamilton C, Niedzwiecki D,

Compton C, Mayer RJ, Goldberg R, Bertagnolli MM, Boland CR. 2007. The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. Gastroenterology, 132 (1): 127-38.

Gong C, Mera R, Bravo JC, Ruiz B, Diaz-Escamilla R, Fontham E, P, Hunt J. 1999. KRAS Mutations Predict Progression of Preneoplastic Gastric Lesions. Cancer Epidemiology, Biomarkers & Prevention, 8: 167-171.

Grady WM, Willis J, Guilford PJ, Dunbier AK, Toro TT, Lynch H, Wiesner G Ferguson K, Eng C, Park JG, Kim SJ, Markowitz S. 2000. Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nature Genetics, 26: 16-17.

Gravalos C, Jimeno A. 2008. HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target. Annals of Oncology, 19 (9): 1523-9.

Hibi K, Sakata M, Sakuraba K, Kitamura YH, Shirahata A, Goto T, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y. 2010. Methylation of the DCC gene is lost in advanced gastric cancer. Anticancer Research, 30 (1): 107-9.

Hoebeeck J, Michels E, Pattyn F, Combaret V, Vermeulen J, Yigit N, Hoyoux C, Laureys G, De Paepe A, Speleman F, Vandesompele J. 2009. Aberrant methylation of candidate tumor suppressor genes in neuroblastoma. Cancer Letters, 273 (2): 336-46.

Hoeijmakers, J. 2009. DNA damage, aging, and cancer. The New

England Journal of Medicine, 361 (15): 1475-85. Holland A, Cleveland, D. 2009. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nature Reviews Molecular Cell Biology, 10 (7): 478-87.

Hu KW, Chen FH, Ge JF, Cao LY, Li H. 2012. Retinoid receptors in gastric cancer: expression and influence on prognosis. Asian Pacific Journal of Cancer Prevention, 13 (5): 1809-17.

Hu SL, Huang DB, Sun YB, Wu L, Xu WP, Yin S, Chen J, Jiang XD, Shen G. 2011. Pathobiologic implications of methylation and expression status of Runx3 and CHFR genes in gastric cancer. Medical Oncology, 28 (2): 447-54.

Hudler P. 2012. Genetic Aspects of Gastric Cancer Instability. Scientific World Journal. [Internet], 2012 (761909): 1-10. Fecha de acceso: 14 de enero de 2013. Disponible en: <http://dx.doi.

org/10.1100/2012/761909>

Huebner K, Druck T, Siprashvili Z, Croce CM, Kovatich A, McCue

PA. 1998. The role of deletions at the FRA3B/FHIT locus in carcinogenesis. Recent Results in Cancer Research, 154: 200-15.

Ikoma H, Ichikawa D, Koike H, Ikoma D, Tani N, Okamoto K, Ochiai T, Ueda Y, Otsuji E, Yamagishi H. 2006. Correlation between Serum

DNA Methylation and Prognosis in Gastric Cancer Patients.

Anticancer Research, 26: 2313-2316.

Im SA, Kim JW, Kim JS, Kim MA, Jordan B, Pickl M, Han SW. 2011.

Clinicopathologic characteristics of patients with stage III/ IV (M(0)) advanced gastric cancer, according to HER2 status assessed by immunohistochemistry and fluorescence in situ hybridization. Diagnostic Molecular Pathology, 20 (2): 94-100.

Ito K, Chuang LS, Ito T, Chang TL, Fukamachi H, Salto-Tellez M, Ito Y. 2011. Loss of Runx3 is a key event in inducing precancerous state of the stomach. Gastroenterology, 140 (5): 1536-46.

Ito K, Lim AC, Salto-Tellez M, Motoda L, Osato M, Chuang LS, Lee

CW, Voon DC, Koo JK, Wang H, Fukamachi H, Ito Y. 2008. RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis. Cancer Cell, 14 (3): 226-37.

Ito K, Liu Q, Salto-Tellez M, Yano T, Tada K, Ida H, Huang C, Shah N,

Inoue M, Rajnakova A, Hiong KC, Peh BK, Han HC, Ito T, Teh M, Yeoh KG, Ito Y. 2005. RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization. Cancer Research, 65 (17): 7743-50.

Ito R, Nakayama H, Yoshida K, Oda N, Yasui W. 2004. Loss of maspin

expression is associated with development and progression of gastric carcinoma with p53 abnormality. Oncology Reports, 12 (5): 985-90.

Jaiswal AS, Narayan S. 2008. A novel function of adenomatous polyposis coli (APC) in regulating DNA repair. Cancer Letters, 271 (2): 272-280.

Jancík S, Drábek J, Radzioch D, Hajdúch M. 2010. Clinical relevance of KRAS in human cancers. Journal of biomedicine & biotechnology

[Internet], 2010 (150960): 1-13. Fecha de acceso: 14 de enero

de 2013. Disponible en: <http://www.pubmedcentral.nih.gov/

articlerender.fcgi?artid=2896632&tool=pmcentrez&rendertyp

e=abstract>

Jang YH, Lim SB, Kim MJ, Chung HJ, Yoo HW, Byeon JS, Myung SJ,

Lee W, Chun S, Min WK. 2010. Three novel mutations of the APC gene in Korean patients with familial adenomatous polyposis. Cancer Genetics and Cytogenetics, 200 (1) : 34-9.

Jin M, Kawakami K, Fukui Y, Tsukioka S, Oda M, Watanabe G, Takechi

T, Oka T, Minamoto T. 2009. Different histological types of non- small cell lung cancer have distinct folate and DNA methylation levels. Cancer Science, 100 (12): 2325-30.

Jørgensen JT, Hersom M. 2012. HER2 as a Prognostic Marker in Gastric Cancer-A Systematic Analysis of Data from the Literature. Journal of Cancer, 3: 137-44.

Katayama Y, Takahashi M, Kuwayama H. 2009. Helicobacter pylori

causes runx3 gene methylation and its loss of expression in gastric epithelial cells, which is mediated by nitric oxide produced by macrophages. Biochemical and Biophysical Research Communications, 388 (3): 496-500.

Kawaguchi K1, Yashima K, Koda M, Tsutsumi A, Kitaoka S, Andachi

H, Hosoda A, Kishimoto Y, Shiota G, Ito H, Murawaki Y. 2004. Fhit expression in human gastric adenomas and intramucosal carcinomas: correlation with Mlh1 expression and gastric phenotype. British Journal of Cancer, 90 (3): 672-7.

Kim JH, Jung EJ, Lee HS, Kim MA, Kim WH. 2009. Comparative analysis of DNA methylation between primary and metastatic gastric carcinoma. Oncology Reports, 21 (5): 1251-9.

Kim TY, Lee HJ, Hwang KS, Lee M, Kim JW, Bang YJ, Kang GH. 2004. Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma. Laboratory Investigation, 84 (4): 479-84.

Kioulafa M, Kaklamanis L, Mavroudis D, Georgoulias V, Lianidou E. 2009. Prognostic significance of RASSF1A promoter methylation in operable breast cancer. Clinical Biochemistry, 42 (10-11): 970-5.

Kitagawa D, Kajiho H, Negishi T, Ura S, Watanabe T, Wada T, Ichijo H, Katada T, Nishina H. 2006. Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. The European Molecular Biology Organization Journal, 25 (14): 3286-97.

Ksiaa F, Ziadi S, Amara K, Korbi S, Trimeche M. 2009. Biological significance of promoter hypermethylation of tumor-related genes in patients with gastric carcinoma. Clinica chimica acta, 404 (2): 128-33.

Lauren, P. 1965. The Two Histological Main Types of Gastric Carcinoma: Diffuse and So-Called Intestinal-Type Carcinoma. An Attempt at a Histo-Clinical Classification. Acta pathologica et microbiologica Scandinavica, 64: 31-49.

Lea IA, Jackson MA, Li X, Bailey S, Peddada SD, Dunnick JK. 2007.

Genetic pathways and mutation profiles of human cancers: site-and exposure-specific patterns. Carcinogenesis, 28 (9): 1851-1858.

Leal MF, Calcagno DQ, Borges da Costa Jde F, Silva TC, Khayat AS, Chen ES, Assumpção PP, de Arruda Cardoso Smith M, Burbano RR. 2011. MYC, TP53, and chromosome 17 copy-number alterations in multiple gastric cancer cell lines and in their parental primary tumors. Journal of biomedicine & biotechnology [Internet], 2011 (631268): 1-18. Fecha de acceso: 14 de enero de 2013. Disponible en: <http://dx.doi.org/10.1155/2011/631268>

Leal M, Lima E, Silva P, Assumpção P, Calcagno D, Payão S, Burbano RR, Smith M. 2007. Promoter hypermethylation of CDH1, FHIT, MTAP and PLAGL1 in gastric adenocarcinoma in individuals from Northern Brazil. World journal of gastroenterology, 13 (18) : 2568-74.

Lee SH, Kim WH, Kim HK, Woo KM, Nam HS, Kim HS, Kim JG, Cho

MH. 2001. Altered expression of the fragile histidine triad gene in primary gastric adenocarcinomas. Biochemical and biophysical research communications, 284 (3): 850-5.

Lehrbach DM, Cecconello I, Ribeiro Jr U, Capelozzi VL, Ab’saber AM, Alves VA. 2009. Adenocarcinoma of the esophagogastric junction: relationship between clinicopathological data and p53, cyclin D1 and Bcl-2 immunoexpressions. Archives of Gastroenterology, 46 (4): 315-320.

Li QL, Ito K, Sakakura C, Fukamachi H, Inoue Ki, Chi XZ, Lee KY,

Nomura S, Lee CW, Han SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC, Ito Y. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell, 109 (1): 113-24.

Li Z, Li W, Song L, Zhu W. 2012. Cilia, adenomatous polyposis coli and associated diseases. Oncogene, 31 (12): 1475-83.

Lima VP, de Lima MA, André AR, Ferreira MV, Barros MA, Rabenhorst SH. 2008. H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression. World journal of gastroenterology, 14 (6): 884-91.

Lin FC, Liu YP, Lai CH, Shan YS, Cheng HC, Hsu PI, Lee CH, Wang HY, Wang CH, Cheng JQ, Hsiao M, Lu PJ. 2012. RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells. Oncogene, 31(39):4302-16.

Liu GY, Liu KH, Zhang Y, Wang YZ, Wu XH, Lu YZ, Pan C, Yin P, Liao

HF, Su JQ, Ge Q, Luo Q, Xiong B. 2010. Alterations of tumor-related genes do not exactly match the histopathological grade in gastric adenocarcinomas. World Journal of Gastroenterology, 16 (9): 1129.

Liu YC, Shen CY, Wu HS, Hsieh TY, Chan DC, Chen CJ, Yu JC, Yu CP, Harn HJ, Chen PJ, Hsieh CB, Chen TW, Hsu HM. 2006. Mechanisms inactivating the gene for E-cadherin in sporadic gastric carcinomas. World journal of gastroenterology, 12 (14): 2168-73.

Loeb L. 2011. Human cancers express mutator phenotypes: origin, consequences and targeting. Nauret Review Cancer, 11 (6): 450-7.

Ongenaert M, Van Neste L, De Meyer T, Menschaert G, Bekaert S, Van Criekinge W. 2008. PubMeth: a cancer methylation database combining text-mining and expert annotation. Nucleic Acids Research, 36 (suppl 1): D842-D846

Mauro LV, Dalurzo M, Smith D, Lastiri J, Vasallo B, Joffei EB, Pallotta MG, Puricelli L. 2008. Retinoid expression (RARbeta and CRBP1) in non-small-cell lung carcinoma. Medicina, 68 (3): 205-212. Mohammadi-asl J, Larijani B, Khorgami Z, Tavangar SM, Haghpanah V, Kheirollahi M, Mehdipour P. 2011. Qualitative and quantitative promoter hypermethylation patterns of the P16, TSHR, RASSF1A and RARβ2 genes in papillary thyroid carcinoma. Medical oncology, 28 (4): 1123-8.

Motoshita J, Oue N, Nakayama H, Kuraoka K, Aung PP, Taniyama K, Matsusaki K, Yasui W. 2005. DNA methylation profiles of differentiated-type gastric carcinomas with distinct mucin phenotypes. Cancer science, 96 (8) 474-9.

Nagini S. 2012. Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention. World journal of gastrointestinal oncology, 4 (7): 156-69.

Neufeld KL. 2009. Nuclear APC. Advances in experimental medicine and biology. 1 (656): 13-29.

Nobili S, Bruno L, Landini I, Napoli C, Bechi P, Tonelli F, Rubio CA, Mini E, Nesi G. 2011. Genomic and genetic alterations influence the progression of gastric cancer. World journal of gastroenterology, 17 (3): 290-9.

Normanno, Nicola, Antonella De Luca, Caterina Bianco, Luigi Strizzi, Mario Mancino, Monica R Maiello, Adele Carotenuto, Gianfranco De Feo, Francesco Caponigro, y David S Salomon. 2006. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene, 366 (1) : 2-16.

Oliveira C, Seruca R, Carneiro F. 2009. Hereditary gastric cancer. Best practice & research. Clinical gastroenterology, 23 (2): 147-57. Oliveira C, Sousa S, Pinheiro H, Karam R, Bordeira-Carriço R, Senz J, Kaurah P, Carvalho J, Pereira R, Gusmão L, Wen X, Cipriano MA, Yokota J, Carneiro F, Huntsman D, Seruca R. 2009. Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. Gastroenterology, 136 (7): 2137-2148.

Oliveira C, Velho S, Domingo E, Preto A, Hofstra RM, Hamelin R, Yamamoto H, Seruca R, Schwartz S. 2005. Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer. Oncogene, 24 (51): 7630-4.

Olivier M, Hollstein M, Hainaut P. 2010. TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harbor perspectives in biology [Internet], 2 (1): a001008. Fecha de acceso: 14 de enero de 2014. Disponible en:

Pan ZG, Kashuba VI, Liu XQ, Shao JY, Zhang RH, Jiang JH, Guo C, Zabarovsky E, Ernberg I, Zeng YX. 2005. High frequency somatic mutations in RASSF1A in nasopharyngeal carcinoma. Cancer biology & therapy, 4 (10): 1116-22.

Panani, A. 2008. Cytogenetic and molecular aspects of gastric cancer: clinical implications. Cancer letters, 266 (2): 99-115. d Panani, A, Roussos C. 2005. Non-random structural chromosomal changes in primary gastric cancer. Cancer letters, 225 (2): 291-5.

Park SY, Kook MC, Kim YW, Cho NY, Kim TY, Kang GH. 2010. Mixed-type gastric cancer and its association with high-frequency CpG island hypermethylation. Virchows Archiv: an international journal of pathology, 456 (6): 625-33.

Park SY, Kwon HJ, Lee HE, Ryu HS, Kim SW, Kim JH, Kim IA, Jung N, Cho NY, Kang GH. 2011. Promoter CpG island hypermethylation during breast cancer progression. Virchows Archiv: an international journal of pathology, 458 (1): 73-84.

Pharoah PD, Guilford P, Caldas C. 2001. Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families. Gastroenterology, 121 (6): 1348-1353.

Piñeros M, Gamboa O, Hernández-Suárez G, Pardo C, Bray F. 2013. Patterns and trends in cancer mortality in Colombia 1984-2008. Cancer epidemiology, 37 (3): 233-9.

Piñeros M, Garay P, Gamboa O, Hernández-Suárez C, Pardo-Ramos G. 2010. Atlas de mortalidad por cáncer en Colombia. 3a ed. Vol. 1. Bogota: Instituto Geográfico Agustín Codazzi (IGAC).p.95.

Polk DB, Peek R. 2010. Helicobacter pylori: gastric cancer and beyond. Nature reviews Cancer, 10 (6) : 403-14.

Power DG, Kelsen DP, a Shah M. 2010. Advanced gastric cancer-slow but steady progress. Cancer treatment reviews, 36 (5): 384-92.

Rajalingam K, Schreck R, Rapp U, Albert S. 2007. Ras oncogenes and their downstream targets. Biochim Biophys Acta, 1773 (8): 1177-95.

Rasti M, Tavasoli P, Monabati A, Entezam M. 2009. Association between HIC1 and RASSF1A promoter hypermethylation with MTHFD1 G1958A polymorphism and clinicopathological features of breast cancer in Iranian patients. Iranian biomedical journal, 13 (4): 199-206.

Richter A, Pfeifer G, Dammann R. 2009. The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Biochimica et biophysica acta, 1796 (2): 114-28.

Richter AM, Schagdarsurengin U, Rastetter M, Steinmann K, Dammann RH. 2010. Protein kinase A-mediated phosphorylation of the RASSF1A tumour suppressor at Serine 203 and regulation of

RASSF1A function. European journal of cancer, 46 (16): 2986-95.

Riquelme E, Tang M, Baez S, Diaz A, Pruyas M, Wistuba I, Corvalan A. 2007. Frequent epigenetic inactivation of chromosome 3p candidate tumor suppressor genes in gallbladder carcinoma. Cancer letters, 250 (1): 100-6.

Roa J, Anabalón L, Roa I, Tapia O, Melo A, Villaseca M, Araya J. 2005. Promoter methylation profile in gastric cancer. Revista Medica de Chile, 133 (8): 874-80.

Roa J, García P, Melo A, Tapia O, Villaseca M, Araya J, Guzmán P. 2008. Gene methylation patterns in digestive tumors. Revista médica de Chile, 136 (4): 451-8.

Saelee P, Wongkham S, Chariyalertsak S, Petmitr S, Chuensumran U. 2010. RASSF1A promoter hypermethylation as a prognostic marker for hepatocellular carcinoma. Asian Pacific journal of cancer prevention, 11 (6): 1677-81.

Sanger Institute. 2011. COSMIC (the Catalogue of Somatic Mutations

in Cancer) [Internet]. Fecha de acceso: 14 de abril de 2013 Disponible en: <http://www.sanger.ac.uk/cosmic> Shivakumar L, Minna J, Sakamaki T, Pestell R, White M. 2002. The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation. Molecular and cellular biology, 22 (12): 4309-18.

Sociedad Americana de Cáncer. 2012. Marcadores tumorales ¿Qué son los marcadores tumorales ? American Cancer Society (ACS) [Internet], Fecha de acceso: 15 de Marzo de 2014. Disponible en:

. Sonobe M, Manabe T, Wada H, Tanaka F. 2006. Lung adenocarcinoma harboring mutations in the ERBB2 kinase domain. The Journal of molecular diagnostics, 8 (3): 351-6.

Subramaniam MM, Chan JY, Yeoh KG, Quek T, Ito K, Salto-Tellez M.

Molecular pathology of RUNX3 in human carcinogenesis. Biochimica et biophysica acta, 1796 (2): 315-31.

Sugai T, Habano W, Uesugi N, Jao YF, Nakamura S, Abe K, Takagane A, Terashima M. 2004. Three independent genetic profiles based on mucin expression in early differentiated-type gastric cancers —a new concept of genetic carcinogenesis of early differentiated- type adenocarcinomas. Modern Pathology, 17 (10): 1223-1234.

Tahara, E. 1995a. Genetic alterations in human gastrointestinal cancers. The application to molecular diagnosis. Cancer, 75 (6 Suppl): 1410-1417.

Tahara E. 1995b. Molecular biology of gastric cancer. World journal of surgery, 19 (4): 484-8; discussion 489-90.

Tahara E. 2004. Genetic pathways of two types of gastric cancer. IARC scientific publications, (157): 327-49.

Tänzer M, Liebl M, Quante M. 2013. Molecular biomarkers in esophageal, gastric, and colorectal adenocarcinoma. Pharmacology & therapeutics, 140 (2): 133-47.

Thompson, L. 2012. Recognition, signaling, and repair of DNA double- strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography. Mutation Research, 751 (2): 158-246.

Tomizawa Y, Iijima H, Nomoto T, Iwasaki Y, Otani Y, Tsuchiya S, Saito R, Dobashi K, Nakajima T, Mori M. 2004. Clinicopathological

significance of aberrant methylation of RARbeta2 at 3p24, RASSF1A at 3p21.3, and FHIT at 3p14.2 in patients with non-small cell lung cancer. Lung cancer, 46 (3): 305-12.

Uozaki H, Fukayama M. 2008. Epstein-Barr virus and gastric carcinoma--viral carcinogenesis through epigenetic mechanisms. International journal of clinical and experimental pathology, 1 (3): 198-216.

Vos MD, Martinez A, Elam C, Dallol A, Taylor BJ, Latif F, Clark GJ. 2004. A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stability. Cancer research, 64 (12): 4244-50.

Wang T, Liu H, Chen Y, Liu W, Yu J, Wu G. 2009. Methylation associated inactivation of RASSF1A and its synergistic effect with activated K-Ras in nasopharyngeal carcinoma. Journal of experimental & clinical cancer research, 30 (28):160-171.

Wang TC, Fox J, Giraud A, editores. 2009. The Biology of Gastric Cancers. 1a ed. New York: Springer New York p.621.

Weiss MM, Kuipers EJ, Postma C, Snijders AM, Pinkel D, Meuwissen

SG, Albertson D, Meijer GA. 2004. Genomic alterations in primary gastric adenocarcinomas correlate with clinicopathological characteristics and survival. Cellular oncology, 26: 307-317.

Wilcox R, Perpich M, Noffsinger A, Posner MC, Cooper K. 2011. Hereditary diffuse gastric cancer: multidisciplinary case report with review of the literature. Pathology research international, 2011: 845821.

Wu Q, Chen ZM, Su WJ. 2002. Anticancer effect of retinoic acid via AP-1 activity repression is mediated by retinoic acid receptor alpha and beta in gastric cancer cells. The international journal of biochemistry & cell biology, 34 (9): 1102-1114.

Wu WK, Cho CH, Lee CW, Fan D, Wu K, Yu J, Sung JJ. 2010. Dysregulation of cellular signaling in gastric cancer. Cancer letters, 295 (2): 144-53.

Xiao YP, Wu DY, Xu L, Xin Y. 2006. Loss of heterozygosity and microsatellite instabilities of fragile histidine triad gene in gastric carcinoma. World Journal of Gastroenterology, 12 (23): 3766-3769.

Yamaguchi H, Chang S, Hsu JL, Hung MC. 2013. Signaling cross- talk in the resistance to HER family receptor targeted therapy. Oncogene, 33(9):1073-81

Yamamoto E, Suzuki H, Takamaru H, Yamamoto H, Toyota M, Shinomura Y. 2011. Role of DNA methylation in the development of diffuse-type gastric cancer. Digestion, 83 (4): 241-9.

Yarmus M, Woolf E, Bernstein Y, Fainaru O, Negreanu V, Levanon D, Groner Y. 2006. Groucho/transducin-like Enhancer-of-split (TLE)-dependent and -independent transcriptional regulation by Runx3. Proceedings of the National Academy of Sciences of the United States of America, 103 (19): 7384-9.

Ye M, Xia B, Guo Q, Zhou F, Zhang X. 2007. Association of diminished expression of RASSF1A with promoter methylation in primary gastric cancer from patients of central China. BioMed Central

cancer, 3 (7): 120.

Ying J, Shen CY, Wu HS, Hsieh TY, Chan DC, Chen CJ, Yu JC, Yu CP,

Harn HJ, Chen PJ, Hsieh CB, Chen TW, Hsu HM. 2009. DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers. British journal of cancer, 100 (4): 663-9.

Zhao P, Liu W, Lu YL. 2005. Clinicopathological significance of FHIT protein expression in gastric adenocarcinoma patients. World journal of gastroenterology, 11 (36): 5735-8.

Zhou Y, Li N, Zhuang W, Liu GJ, Wu TX, Yao X, Du L, Wei ML, Wu XT. 2007. P53 codon 72 polymorphism and gastric cancer: a meta analysis of the literature. International journal of cancer, 121 (7): 1481-6.

Zou XP, Zhang B, Zhang XQ, Chen M, Cao J, Liu WJ. 2009. Promoter hypermethylation of multiple genes in early gastric adenocarcinoma and precancerous lesions. Human pathology, 40 (11) : 1534-42.

Descargas

Publicado

2017-09-21

Cómo citar

Pérez - Cala, T., Camargo, M., & Martínez, A. (2017). Factores genéticos y epigenéticos del cáncer gástrico. Actualidades Biológicas, 39(106), 5–20. https://doi.org/10.17533/udea.acbi.v39n106a01

Número

Sección

Artículos de revisión

Artículos más leídos del mismo autor/a

1 2 > >>