Uso de los flavonoides en modelos experimentales de glioblastoma multiforme
DOI:
https://doi.org/10.17533/udea.acbi/v47n123a09Palavras-chave:
Cultivo celular, Fitoterapia, Glioblastoma multiforme, flavonoides, Modelos in vitro, Terapia celularResumo
El Glioblastoma Multiforme (GBM) representa al tumor con mayor malignidad e incidencia y prevalencia de aquellos que se desarrollan a nivel de Sistema Nervioso Central (CNS). El uso de flavonoides ha venido tomando fuerza de forma alternativa y coadyuvante para contrarrestar la aparición y el desarrollo de diversos tipos de cáncer, dentro de ellos el GBM. El objetivo de esta revisión fue analizar el uso de flavonoides de diferentes fuentes vegetales en modelos experimentales de GBM en una ventana de búsqueda de diez años (2013-2023). Se revisaron cincuenta y un artículos dentro de los que se encuentran artículos originales y revisiones bibliográficas. En conclusión, los flavonoides han sido probados en diferentes modelos in vitro de GBM, disminuyendo la proliferación y la angiogénesis, activando vías de señalización y redireccionando la actividad celular a vías alternas que evoquen apoptosis y reparación celular.
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