Péptidos antimicrobianos: Estructura, función y aplicaciones

Pablo Gutiérrez; Sergio Orduz

doi:10.17533/udea.acbi.329497

Autores

Pablo Gutiérrez Unidad de Biotecnología y Control Biológico
Sergio Orduz Corporación para Investigaciones Biológicas (CIB)

DOI:

https://doi.org/10.17533/udea.acbi.329497

Palavras-chave:

peptídeos, antimicrobiano, alfa hélice, antibiótico

Resumo

Os peptídeos antimicrobianos recentemente descobertos correspondem a uma primeira linha de defesa contra patógenos. Eles foram descritos a partir de bactérias, insetos, plantas e vertebrados, e vários grupos de peptídeos antimicrobianos são conhecidos dependendo de sua estrutura: alfa-helicoidal, estrutura estendida e composição irregular, para os quais vários modelos de interação com membranas de bactérias, mas, em em geral, os peptídeos causam poros líticos. Na maioria dos casos, esses peptídeos são sintetizados ribossomicamente, alguns como pré-proteínas. Uma série de aplicações têm sido propostas para o controle de infecções bacterianas, especialmente aquelas localizadas na pele ou nas mucosas. Plantas transgênicas que expressam peptídeos antimicrobianos foram desenvolvidas e a incidência de doenças foi reduzida

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Biografia do Autor

Pablo Gutiérrez, Unidad de Biotecnología y Control Biológico

Unidad de Biotecnología y Control Biológico, Corporación para Investigaciones Biológicas (CIB), apartado 7378, Medellín, Colombia. E-mail: sorduz@cib.org.co

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