Multidimensional Frailty and Traumatic Brain Injury among Older Adults: A Literature Review
DOI:
https://doi.org/10.17533/udea.iee.v41n2e02Keywords:
frail elderly, brain injuries, multiple trauma, accidental fallsAbstract
Background. Numerous health conditions in the older adult population can be attributed to falls, including traumatic brain injury (TBI), which can lead to devastating short and long-term sequelae. Older adults are also more likely to experience frailty, which encompasses physical, psychological, and social deficits that may lead to adverse health outcomes. Our literature review synthesizes current evidence for understanding frailty in the context of TBI among older adults using the Integral Model of Frailty as a framework. Content synthesis. A total of 32 articles were identified, and 9 articles were included. The results of this review indicate that outcomes resulting from TBI are closely linked to the physical, psychological, and social domains of frailty. Conclusions. A small amount of literature currently examines frailty in the context of TBI among older adults. Using the Integral Model of Frailty to understand frailty in the context of TBI can help clinicians anticipate patient outcomes and improve care plans. We emphasize the need for a greater understanding of TBI concerning frailty to improve health outcomes among older adult patients.
Downloads
References
1. World population ageing 2020 highlights | population division [Internet]. United Nations. United Nations; 2020 [cited
Apr 29]. Available from: https://www.un.org/development/desa/pd/news/world-population-ageing-2020-
highlights
2. Bell SP, Patel N, Patel N, Sonani R, Badheka A, Forman DE. Care of older adults. J. Geriatr. Cardiol. 2016;
(1):1-7.
3. Buckinx F, Rolland Y, Reginster J-Y, Ricour C, Petermans J, Bruyère O. Burden of frailty in the elderly population:
perspectives for a public health challenge. Arch. Public. Health. 2015; 73(1):19.
4. Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet 2013; 381(9868):752-62.
5. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: Evidence for a
phenotype. J. Gerontol. 2001; 56(3):M146-M156.
6. Bandeen-Roche K, Xue QL, Ferrucci L, Walston J, Guralnik JM, Chaves P, et al. Phenotype of frailty:
Characterization in the women's health and aging studies. J. Gerontol. 2006;61(3):262-6.
7. Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. Sci. World J. 2001;
:323-36.
8. Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J. Gerontol. 2007; 62(7):722-7.
9. Cheng MH, Chang SF. Frailty as a risk factor for falls among community-dwelling people: Evidence from a meta-
analysis. J. Nurs. Scholarsh. 2017; 49(5):529-36.
10. Thompson HJ, Mccormick WC, Kagan SH. Traumatic brain injury in older adults: epidemiology, outcomes, and
future implications. JAGS 2006; 54(10):1590-5.
11. Mallya S, Sutherland J, Pongracic S, Mainland B, Ornstein TJ. The manifestation of anxiety disorders after
traumatic brain injury: A review. J. Neurotrauma. 2015; 32(7):411-21.
12. Fann JR, Hart T, Schomer KG. Treatment for depression after traumatic brain injury: a systematic review. J.
Neurotrauma. 2009; 26(12):2383-402.
13.Chodobski A, Zink BJ, Szmydynger-Chodobska J. Blood-brain barrier pathophysiology in traumatic brain injury.
Transl. Stroke Res. 2011; 2(4):492-516.
14.Thompson HJ, Bourbonniere M. Traumatic injury in the older adult from head to toe. Crit. Care Nurs. Clin. 2006;
(3):419-31.
15. Arcos-Burgos M, Lopera F, Sepulveda-Falla D, Mastronardi C. Neural Plasticity during Aging. Neural. Plast. 2019:
16. Hukkelhoven CW, Steyerberg EW, Rampen AJ, Farace E, Habbema JD, Marshall LF, et al. Patient age and
outcome following severe traumatic brain injury: An analysis of 5600 patients. J. Neurosurg. 2003; 99(4):666-73.
17. Bramlett HM, Dietrich WD. Long-Term consequences of traumatic brain injury: Current status of potential
mechanisms of injury and neurological outcomes. J. Neurotrauma. 2015; 32(23):1834-48.
18. Ryan LM, Warden DL. Post-concussion syndrome. Int. Rev. 2003; 15(4):310-6.
19.Daneshvar DH, Riley DO, Nowinski CJ, Mckee AC, Stern RA, Cantu RC. Long-term consequences: Effects on
normal development profile after concussion. Phys. Med. Rehabil. Clin. N. Am. 2011; 22(4):683-700.
20. Gobbens RJ, Luijkx KG, Wijnen-Sponselee MT, Schols JM. Towards an integral conceptual model of frailty. J. Nutr.
; 14(3):175-81.
21. Gobbens RJ, van Assen MA, Luijkx KG, Schols JM. Testing an integral conceptual model of frailty. J. Adv. Nurs.
; 68(9):2047-60.
22. Gobbens RJ, van Assen MA. Associations between multidimensional frailty and quality of life among Dutch older
people. Arch. Gerontol. Geriatr. 2017; 73:69-76.
23. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an
updated guideline for reporting systematic reviews. BMJ. 2021; 372:71.
24. Newhouse RP, Dearholt SL. Johns Hopkins nursing evidence-based practice model and guidelines. Indianapolis,
In: Sigma Theta Tau International Honor Society of Nursing; 2007.
25. Abdulle AE, de Koning ME, van der Horn HJ, Scheenen ME, Roks G, Hageman G, et al. Early predictors for long-
term functional outcome after mild traumatic brain injury in frail elderly patients. J. Head Trauma Rehabil. 2018;
(6):E59-E67.
26. Boyé ND, Mattace-Raso FU, Van der Velde N, Van Lieshout EM, De Vries OJ, Hartholt KA, et al. Circumstances
leading to injurious falls in older men and women in the Netherlands. Injury. 2014; 45(8):1224-30.
27. Brown K, Cameron ID, Keay L, Coxon K, Ivers R. Functioning and health-related quality of life following injury in
older people: A systematic review. Inj. Prev. 2017; 23(6):403-11.
28. De Luca R, Maggio MG, Naro A, Portaro S, Cannavò A, Calabrò RS. Can patients with severe traumatic brain injury
be trained with cognitive telerehabilitation? An inpatient feasibility and usability study. J. Clin. Neurosci. 2020;
:246-50.
29. Harvey LA, Mitchell R, Brodaty H, Draper B, Close JCT. Comparison of fall-related traumatic brain injury in
residential aged care and community-dwelling older people: A population-based study. Australas. J. Ageing 2017;
(2):144-50.
30. Prabhakaran K, Gogna S, Lombardo G, Latifi R. Venous thromboembolism in geriatric trauma patients—risk factors
and associated outcomes. J. Surg. Res. 2020 ;254:327-33.
31. Stein DG, Cekic MM. Progesterone and vitamin D hormone as a biologic treatment of traumatic brain injury in the
aged. PM R. 2011; 3(6 Suppl 1):S100-10.
32. Teo DB, Wong HC, Yeo AW, Lai YW, Choo EL, Merchant RA. Characteristics of fall-related traumatic brain injury in
older adults. Intern. Med. J. 2018; 48(9):1048-55.
33. Tracy BM, Carlin MN, Tyson JW, Schenker ML, Gelbard RB. The 11-item modified frailty index as a tool to predict
unplanned events in traumatic brain injury. Am. Surg. 2020; 86(11):1596-601.
34. Boxer RS, Dauser DA, Walsh SJ, Hager WD, Kenny AM. The association between vitamin D and inflammation with
the 6-minute walk and frailty in patients with heart failure. JAGS; 2008; 56(3):454-61.
35. Morley JE, Haren MT, Rolland Y, Kim MJ. Frailty. Med. Clin. North Am. 2006; 90(5):837-47
36. Guo Q, Sayeed I, Baronne LM, Hoffman SW, Guennoun R, Stein DG. Progesterone administration modulates
AQP4 expression and edema after traumatic brain injury in male rats. Exp. Neurol. 2006; 198(2):469-78.
37. Rabinowitz AR, Arnett PA. Positive psychology perspective on traumatic brain injury recovery and rehabilitation.
Appl. Neuropsychol. Adult. 2018; 25(4):295-303.
38. Kristman VL, Brison RJ, Bédard M, Reguly P, Chisholm S. Prognostic markers for poor recovery after mild
traumatic brain injury in older adults: A pilot cohort study. J. Head Trauma Rehabil. 2016; 31(6):E33-E43.
39. Liu B, Liu J, Wang M, Zhang Y, Li L. From Serotonin to Neuroplasticity: Evolvement of Theories for Major
Depressive Disorder. Front. Cell. Neurosci. 2017; 11:305.
40. Sheikh-Wu SF, Gerber KS, Pinto MD, Downs CA. Mechanisms and methods to understand depressive symptoms.
Issues Ment. Health Nurs. 2022; 43(5):434-46.
41. Wong AD, Ye M, Levy AF, Rothstein JD, Bergles DE, Searson PC. The blood-brain barrier: an engineering
perspective. Front. Neuroeng. 2013; 6(7):1-22.
42. Vuokila N, Aronica E, Korotkov A, van Vliet EA, Nuzhat S, Puhakka N, et al. Chronic regulation of mir-124-3P in the
perilesional cortex after experimental and human TBI. Int. J. Mol. Sci. 2020; 21(7):2418.
43. Perry E, Howes M-JR. Medicinal plants and dementia therapy: Herbal hopes for brain aging? CNS Neurosci. Ther.
; 17(6):683-98.
44. Durazzo TC, Mattsson N, Weiner MW. Smoking and increased Alzheimer's disease risk: A review of potential
mechanisms. Alzheimers Dement. 2014; 10(3 Suppl):S122-S145.
45. Huibregtse ME, Bazarian JJ, Shultz SR, Kawata K. The biological significance and clinical utility of emerging blood
biomarkers for traumatic brain injury. Neurosci. Biobehav. Rev. 2021; 130:433-47.
46. Leclerc E, Sturchler E, Vetter SW. The S100B/RAGE Axis in Alzheimer's Disease. Cardiovasc. Psychiatry Neurol.
; 2010:539581.
47. Johnson VE, Stewart W, Smith DH. Traumatic brain injury and amyloid-β pathology: A link to Alzheimer's Disease?
Nat. Rev. Neurosci. 2010; 11(5):361-70.
48. Dijkers M, Brandstater M, Horn S, Ryser D, Barrett R. Inpatient rehabilitation for traumatic brain injury: the influence
of age on treatments and outcomes. NeuroRehabilitation. 2013; 32(2):233-52.
49. Gómez-Gómez ME, Zapico SC. Frailty, cognitive decline, neurodegenerative diseases and nutrition interventions.
Int. J. Mol. Sci. 2019; 20(11):2842.
50. Mosenthal AC, Livingston DH, Lavery RF, Knudson MM, Lee S, Morabito D, et al. The effect of age on functional
outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial. J. Trauma Inj. 2004;
(5):1042-8.
51. Rothweiler B, Temkin NR, Dikmen SS. Aging effect on psychosocial outcome in traumatic brain injury. Arch. Phys.
M 1998;79(8):881-887
52. Testa JA, Malec JF, Moessner AM, Brown AW. Outcome after traumatic brain injury: effects of aging on recovery.
Arch. Phys. Med. Rehabil. 2005; 86(9):1815-23.
53. Health Evidence™. Helping public health use best evidence in practice since 2005: Quality assessment tool-review
articles. [Internet] 2016 [cited 2022 May 31]. Available from: https://www.healthevidence.org
54. Health topics. National Heart Lung and Blood Institute. [Internet] 2021 [cited 2022 May 31]. Available from:
Published
Versions
- 2023-10-19 (2)
- 2023-06-20 (1)
How to Cite
Issue
Section
License
Copyright (c) 2023 Investigación y Educación en Enfermería
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Derechos de propiedad / Direitos de Propriedade
English: If the article is accepted for publication, all copyright will be of exclusive property of Investigación y Educación en Enfermería. The text and the graphics included in the publication are exclusive responsibility of the authors and not necessarily reflect the thought of the Editorial Committee.
Español: Si el artículo es aprobado para publicación, todos los derechos son de propiedad de Investigación y Educación en Enfermería. El texto y las gráficas incluidas en la publicación son de exclusiva responsabilidad de los autores y no necesariamente refleja el pensamiento del Comité Editorial.
Português: Se o artigo for aceito para publicação, todos os direitos autorais serão de propriedade exclusiva de Investigación y Educación en Enfermería. O texto e os gráficos incluídos na publicação são de responsabilidade exclusiva dos autores e não refletem necessariamente o pensamento do Comitê Editorial.