CFD simulation and validation of flow in small arteries to enable further drug delivery studies

Keywords: Computational fluid dynamics, finite element analysis, experimental validation, localized drug delivery

Abstract

Treatments based on nanocarriers such as nanoparticles have emerged as alternatives to overcome common limitations and side effects caused by traditional treatments against cancer and neurological diseases. The main attribute of nanoparticles stems from the fact that they can transport pharmacological agents in a guided manner. This allows drugs to selectively target diseased rather than healthy tissues. This work was aimed at modeling and simulating fluid flow inside small arteries and experimentally validating the model through quantitative measurements of pressure and flow rates. The validity of the model was evaluated in the light of different indexes of percentage agreement between simulated and measured values. The model was previously verified via mesh convergence analysis and qualitative observations of velocity profile. Our findings provide a robust basis for studying nanoparticle transport in arteries as the developed platform enables their releasing and remote manipulation both in silico and in vitro.

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Author Biographies

Marcela Mercado-Montoya, Universidad de Antioquia

Bioengineer, MSc Student

Juan Carlos Cruz-Jiménez, Universidad de los Andes

Assistant Professor, Department of Biomedical Engineering

Alher Mauricio Hernandez, Universidad de Antioquia

Electronic engineer, PhD in biomedical engineering

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Published
2019-04-22