CFD simulation and validation of flow in small arteries to enable further drug delivery studies




Computational fluid dynamics, Finite element analysis, Experimental validation, Localized drug delivery


Treatments based on nanocarriers such as nanoparticles have emerged as alternatives to overcome common limitations and side effects caused by traditional treatments against cancer and neurological diseases. The main attribute of nanoparticles stems from the fact that they can transport pharmacological agents in a guided manner. This allows drugs to selectively target diseased rather than healthy tissues. This work was aimed at modeling and simulating fluid flow inside small arteries and experimentally validating the model through quantitative measurements of pressure and flow rates. The validity of the model was evaluated in the light of different indexes of percentage agreement between simulated and measured values. The model was previously verified via mesh convergence analysis and qualitative observations of velocity profile. Our findings provide a robust basis for studying nanoparticle transport in arteries as the developed platform enables their releasing and remote manipulation both in silico and in vitro.

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Author Biographies

Marcela Mercado-Montoya, University of Antioquia

Research Group in Bioinstrumentation and Clinical Engineering - GIBIC, Bioengineering Program, Faculty of Engineering.

Juan Carlos Cruz-Jiménez, University of Los Andes

Assistant Professor, GINIB Research Group, Department of Biomedical Engineering.

Alher Mauricio Hernández, University of Antioquia

Research Group in Bioinstrumentation and Clinical Engineering - GIBIC, Bioengineering Program, Faculty of Engineering.


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How to Cite

Mercado-Montoya, M., Cruz-Jiménez, J. C., & Hernández, A. M. (2020). CFD simulation and validation of flow in small arteries to enable further drug delivery studies. Revista Facultad De Ingeniería Universidad De Antioquia, (97), 78–86.

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