CFD simulation and validation of flow in small arteries to enable further drug delivery studies
Treatments based on nanocarriers such as nanoparticles have emerged as alternatives to overcome common limitations and side effects caused by traditional treatments against cancer and neurological diseases. The main attribute of nanoparticles stems from the fact that they can transport pharmacological agents in a guided manner. This allows drugs to selectively target diseased rather than healthy tissues. This work was aimed at modeling and simulating fluid flow inside small arteries and experimentally validating the model through quantitative measurements of pressure and flow rates. The validity of the model was evaluated in the light of different indexes of percentage agreement between simulated and measured values. The model was previously verified via mesh convergence analysis and qualitative observations of velocity profile. Our findings provide a robust basis for studying nanoparticle transport in arteries as the developed platform enables their releasing and remote manipulation both in silico and in vitro.
W. Aadinath, T. Ghosh, and C. Anandharamakrishnan, “Multimodal magnetic nano-carriers for cancer treatment: Challenges and advancements,” Journal of Magnetism and Magnetic Materials, vol. 401, March 01 2016. [Online]. Available: https://doi.org/10.1016/j. jmmm.2015.10.123
L. Agiotis and et al., “Magnetic manipulation of superparamagnetic nanoparticles in a microfluidic system for drug delivery applications,” J. Magn. Magn. Mater., vol. 401, March 01 2016. [Online]. Available: https://doi.org/10.1016/j.jmmm.2015.10.111
J. K. Patra and et al., “Nano based drug delivery systems: Recent developments and future prospects 10 technology 1007 nanotechnology 03 chemical sciences 0306 physical chemistry (incl. structural) 03 chemical sciences 0303 macromolecular and materials chemistry 11 medical and health sciences 1115 pharmacology and pharmaceutical sciences 09 engineering 0903 biomedical engineering prof ueli aebi, prof peter gehr,” J. Nanobiotechnology, vol. 16, no. 1, September 19 2018. [Online]. Available: https://doi.org/10.1186/s12951-018-0392-8
A. P. Singh, A. Biswas, A. Shukla, and P. Maiti, “Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles,” Signal Transduct. Target. Ther., vol. 4, August 30 2019. [Online]. Available: https://doi.org/10.1038/s41392-019-0068-3
T. Tagami, M. Taki, and T. Ozeki, Nanomaterials in Pharmacology, 39th ed. New York, USA: Springer, 2016.
Wahajuddin and S. Arora, “Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers,” Int. J. Nanomedicine, vol. 7, 2012. [Online]. Available: https: //doi.org/10.2147/IJN.S30320
R. Tietze and et al., “Magnetic nanoparticle-based drug delivery for cancer therapy,” Biochem. Biophys. Res. Commun., vol. 468, no. 3, December 18 2015. [Online]. Available: https://doi.org/10.1016/j. bbrc.2015.08.022
T. D. Do, Y. Noh, M. O. Kim, and J. Yoon, “An electromagnetic steering system for magnetic nanoparticle drug delivery,” in 12th International Conference on Ubiquitous Robots and Ambient Intelligence (URAI), Goyang, South Korea, 2015, pp. 528–531.
W. A. Banks, “From blood-brain barrier to blood-brain interface: new opportunities for cns drug delivery,” Nat. Rev. Drug Discov., vol. 15, no. 4, April 2016. [Online]. Available: https://doi.org/10. 1038/nrd.2015.21
I. Khalin, R. Alyautdin, M. I. Nafeeza, M. H. Haron, and D. Kuznetsov, “Nanoscale drug delivery systems and the blood-brain barrier,” Int. J. Nanomedicine, vol. 9, February 2014. [Online]. Available: https://doi.org/10.2147/IJN.S52236
M. Srikanth and J. A. Kessler, “Nanotechnology-novel therapeutics for cns disorders,” Nat. Rev. Neurol., vol. 8, no. 6, April 2012. [Online]. Available: https://doi.org/10.1038/nrneurol.2012.76
C. Saraiva and et al., “Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases,” J. Control. Release, vol. 10, August 2016. [Online]. Available: https://doi.org/10.1016/j.jconrel.2016.05.044
P. M. Valencia, O. C. Farokhzad, R. Karnik, and R. Langer, “Microfluidic technologies for accelerating the clinical translation of nanoparticles,” Nat. Nanotechnol., vol. 7, no. 10, October 2012. [Online]. Available: https://doi.org/10.1038/nnano.2012.168
A. H. Choi, R. C. Conway, and B. Ben-Nissan, “Finite-element modeling and analysis in nanomedicine and dentistry,” Nanomedicine, vol. 9, no. 11, August 2014. [Online]. Available: https://doi.org/10.2217/nnm.14.75
G. A. Truskey, F. Yuan, and D. F. Katz, Transport Phenomena in Biological Systems, 2nd ed. Durham, NC: Pearson Prentice Hall, 2004.
(2015) Package ‘hydroGOF’ title goodness-of-fit functions for comparison of simulated and observed hydrological time series. hydroGOF. Accessed Oct. 13, 2016. [Online]. Available: https: //bit.ly/2O76ehv
P. Krause, D. P. Boyle, and F. Base, “Comparison of different efficiency criteria for hydrological model assessment,” Adv. Geosci., vol. 5, December 16 2005. [Online]. Available: https://doi.org/10. 5194/adgeo-5-89-2005
M. Mercado, A. M. Hernandez, and J. C. Cruz, “Permanent magnets to enable highly-targeted drug delivery applications: A computational and experimental study,” in VII Latin American Congress on Biomedical Engineering CLAIB, Bucaramanga, Colombia, 2016, pp. 557–560.
Copyright (c) 2020 Revista Facultad de Ingeniería Universidad de Antioquia
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
All the texts included in the Revista Facultad de Ingenieria Universidad de Antioquia -redin- are protected by copyrights. According to the law, their reproduction through any means, physical or electronic, without written consent by the Editorial Committee is forbidden. Complete texts of the articles will be fully and publically available, which means that they can be read, downloaded, copied, distributed, printed, searched for, or linked to. The opinions expressed in the published articles specifically belong to the authors and are not necessarily the same of the Editorial Committee or of the School of Engineering Management.