Clinical, pathological, and immunohistochemical analysis of Schwannoma in oral cavity: a case report

Authors

  • Paola Bueno-Mercado Institución Universitaria Colegios de Colombia (UNICOC)
  • Julio César Osorio Institución Universitaria Colegios de Colombia (UNICOC)
  • Carlos Emiro Tasamá Institución Universitaria Colegios de Colombia (UNICOC)
  • Paula C. Bermúdez-Jaramillo Pontificia Universidad Javeriana

DOI:

https://doi.org/10.17533/udea.rfo.v28n2a12

Keywords:

Schwannoma, Schwann cells, Oral diseases, Rare case

Abstract

A schwannoma is a slow-growing benign neoplasm of the peripheral nerves composed of Schwann cells. Pathologically, is characterized by solid, subcutaneous, asymptomatic lesions. Histologically, it is made of prototypes of cellular organization called Antoni A and Antoni B. The most common site for its occurrence is the tongue, followed by the palate, the floor of the mouth, the buccal mucosa, the lips, and the mandible. This article describes the case of a 55-year-old woman presenting with a firm, nodular, encapsulated mass in the sub mucous area of the vestibular zone behind the right cheek. The clinical, pathological, and immunohistochemical analysis showed that this was a case of intraoral schwannoma

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Author Biographies

Paola Bueno-Mercado, Institución Universitaria Colegios de Colombia (UNICOC)

DDM. Specialist in Periodontics. Specialist in Hospital Management. Former professor of Clinical Practicum in Periodontics.

Julio César Osorio, Institución Universitaria Colegios de Colombia (UNICOC)

Biologist. MSc in Biology. Research Professor

Carlos Emiro Tasamá, Institución Universitaria Colegios de Colombia (UNICOC)

DMD. Specialist in Pathology. Master’s degree in Higher Education. Professor of General and Oral Pathology.

Paula C. Bermúdez-Jaramillo, Pontificia Universidad Javeriana

DMD. Master’s degree in Health Administration MBA

References

Jadwani S, Bansod S, Mishra B. Intraoral Schwannoma in Retromolar Region. J Maxillofac Oral Surg 2012; 11(4): 491-494. DOI: 10.1007/s12663-010-0100-1 URL: https://dx.doi.org/10.1007/s12663-010-0100-1

Avgerinos D, Heenatigala M, Lo A. A rare case of cystic Schwannoma of the portal triad. Einstein J Biol Med 2012; 28(1): 33-35. DOI: 10.23861/EJBM20122815 URL: http://dx.doi.org/10.23861/EJBM20122815

Nascimento G, Albuquerque Pires Rocha D, Galvão H, Lisboa Lopes Costa A, Souza L. A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study. Clin Oral Invest 2011; 15(3): 329-335. DOI: 10.1007/s00784-010-0389-7 URL: https://doi.org/10.1007/s00784-010-0389-7

Corona AP, Oliveira JC, Souza FPAd, Santana LV, Rêgo MAV. Risk factors associated with vestibulocochlear nerve schwannoma: systematic review. Braz J Otorhinolaryngol 2009; 75: 593-615.

Salla JT, Johann ACBR, Garcia BG, Aguiar MCF, Mesquita RA. Retrospective analysis of oral peripheral nerve sheath tumors in Brazilians. Braz Oral Res 2009; 23: 43-48.

Kurup S, Thankappan K, Krishnan N, Nair PP. Intraoral schwannoma – a report of two cases. BMJ Case Rep 2012; 2012. DOI: 10.1136/bcr.12.2011.5389 URL: https://doi.org/10.1136/bcr.12.2011.5389

Shetty SR, Mishra C, Shetty P, Kaur A, Babu S. Palatal schwannoma in an elderly woman. Gerodontology 2012; 29(2): e1133-e1135. DOI: 10.1111/j.1741-2358.2010.00415.x URL: https://doi.org/10.1111/j.1741-2358.2010.00415.x

Parikh RN , N D. Intra-oral schwannoma (neurilemmoma): An unusual anterior palatal swelling–a case report. J Int Oral Health 2010; 2(4): 87-91.

Miranda-Maldonado I, Peña-Ramirez D, Tamez-Motes D, Barboza-Quintana O, Niderhauser-Garcia A, Ancer-Rodriguez J, et al. Schwannoma maligno con diferenciacion rabdomioblástica metastásico a cerebro. Arch Neurocien (Mex) 2010; 15(4): 267-270.

Martins MD, Anunciato de Jesus L, Fernandes KP, Bussadori SK, Taghloubi SA, Martins MA. Intra-oral schwannoma: case report and literature review. Indian J Dent Res 2009 Jan-Mar; 20(1): 121-125.

Kawahara E, Oda Y, Ooi A, Katsuda S, Nakanishi I, Umeda S. Expression of glial fibrillary acidic protein (GFAP) in peripheral nerve sheath tumors: a comparative study of immunoreactivity of gfap, Vimentin, S-100 Protein, and Neurofilament in 38 Schwannomas and 18 neurofibromas. The Am J Surg Pathol 1988; 12(2): 115-120.

Buric N, Jovanovic G, Pesic Z, Krasic D, Radovanovic Z, Mihailovic D et al. Mandible schwannoma (neurilemmoma) presenting as periapical lesion. Dentomaxillofac Radiol 2009 March 1, 2009; 38(3): 178-181. DOI: 10.1259/dmfr/59344498 URL: https://doi.org/10.1259/dmfr/59344498

Eguia A, Uribarri A, Gay Escoda C, Crovetto MA, Martínez-Conde R, Aguirre JM. Tumor de células granulares: Presentación de 8 casos con localización intraoral. Med Oral Patol Oral Cir Bucal 2006; 11(5): 425-428.

Di Giovanni A, Parente P, Colli R. Recurrent plexiform schwannoma in vestibular mucosa. G Chir 2006 Mar; 27(3): 105-108.

Handschel J, Heikaus S, Depprich R, Kubler NR, Yekta SS, Smeets R et al. Intraoral schwannoma: review of the literature and presentation of a rare case. Cranio 2012; 30(2): 150-153. DOI: 10.1179/crn.2012.022 URL: https://doi.org/10.1179/crn.2012.022

Jones A, Franklin C. An analysis of oral and maxillofacial pathology found in adults over a 30-years period. Oral Patol Med 2006; 35: 392-401.

García de Marcos JA, Ruiz Masera JJ, Dean Ferrer A, Alamillos Granados F, Zafra Camacho F, Barrios Sánchez G et al. Neurilemomas de cavidad oral y cuello. Rev Esp Cir Oral Maxilofac 2004; 26: 384-392.

Bayindir T, Kalcioglu MT, Cicek MT, Karadag N, Karaman A. Schwannoma with an uncommon upper lip location and literature review. Case Rep Otolaryngol 2013; 2013: 363049. DOI: 10.1155/2013/363049 URL: https://doi.org/10.1155/2013/363049

Sardinha S, Olímpio A, Agustin P, Fernandes R, Moraes M. Schwannoma of the oral cavity. Histological and immunohistochemical features. Braz J Oral Sci 2005; 4(14): 806-809.

González-García R, Naval-Gías L, Sastre-Pérez J. Tumor fibroso solitario de la cavidad oral con características histológicas de malignidad. Rev Esp Cir Oral Maxilofac 2008; 30: 459-460.

Donato R. Intracellular and extracellular roles of S100 proteins. Microsc Res Tech 2003 Apr 15; 60(6): 540-551. DOI: 10.1002/jemt.10296 URL: https://doi.org/10.1002/jemt.10296

Nonaka D, Chiriboga L, Rubin BP. Differential expression of S100 protein subtypes in malignant melanoma, and benign and malignant peripheral nerve sheath tumors. J Cutan Pathol 2008 Nov; 35(11): 1014-1019. DOI: 10.1111/j.1600-0560.2007.00953.x URL: https://doi.org/10.1111/j.1600-0560.2007.00953.x

Wolf R, Ruzicka T, Yuspa SH. Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function. Amino Acids 2011; 41(4): 789-796. DOI: 10.1007/s00726-010-0666-4 URL: https://doi.org/10.1007/s00726-010-0666-4

Di Bella A, Regoli M, Nicoletti C, Ermini L, Fonzi L, Bertelli E. An appraisal of intermediate filament expression in adult and developing pancreas: vimentin is expressed in alpha cells of rat and mouse embryos. J Histochem Cytochem 2009; 57(6): 577-586. DOI: 10.1369/jhc.2009.952861 URL: https://doi.org/10.1369/jhc.2009.952861

Johnson MD, Glick AD, Davis BW. Immunohistochemical evaluation of Leu-7, myelin basic-protein, S100-protein, glial-fibrillary acidic-protein, and LN3 immunoreactivity in nerve sheath tumors and sarcomas. Arch Pathol Lab Med 1988; 112(2): 155-160.

Perentes E, Rubinstein LJ. Recent applications of immunoperoxidase histochemistry in human neuro-oncology. An update. Arch Pathol Lab Med 1987; 111(9): 796-812.

Varghese SS, Mathew P, Jose J. Diagnostically relevant molecular markers in head and neck neoplasms. ISRN Biomarkers 2013; 2013: 6.

Fuchs E, Weber K. Intermediate filaments: structure, dynamics, function, and disease. Annu Rev Biochem 1994; 63: 345-382. DOI: 10.1146/annurev.bi.63.070194.002021 URL: https://doi.org/10.1146/annurev.bi.63.070194.002021

Castro-Vargas E, Baquerizo-Nole K, Muñoz-Chavez S. Neurofibroma circunscrito solitario. Dermatol Peru 2008; 18(1): 55-58.

Grabowski P, Schonfelder J, Ahnert-Hilger G, Foss HD, Heine B, Schindler I et al. Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectum. Virchows Archiv 2002 Sep; 441(3): 256-263. DOI: 10.1007/s00428-002-0650-9 URL: https://doi.org/10.1007/s00428-002-0650-9

Seppala MT, Haltia MJ, Sankila RJ, Jaaskelainen JE, Heiskanen O. Long-term outcome after removal of spinal schwannoma: a clinicopathological study of 187 cases. J Neurosurg 1995; 83(4): 621-626. DOI: 10.3171/jns.1995.83.4.0621 URL: https://doi.org/10.3171/jns.1995.83.4.0621

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Published

2017-06-30

How to Cite

Bueno-Mercado, P., Osorio, J. C., Tasamá, C. E., & Bermúdez-Jaramillo, P. C. (2017). Clinical, pathological, and immunohistochemical analysis of Schwannoma in oral cavity: a case report. Revista Facultad De Odontología Universidad De Antioquia, 28(2), 433–444. https://doi.org/10.17533/udea.rfo.v28n2a12