El papel de la insulina en la regulación de la síntesis de proteínas lácteas en bovinos
DOI:
https://doi.org/10.17533/udea.rccp.324494Palabras clave:
control hormonal, glándula mamaria, homeorresisResumen
No obstante la importancia nutricional e industrial de las proteínas lácteas, aún no están completamente comprendidos los mecanismos que controlan su síntesis y concentración. Entre las distintas hormonas que regulan el metabolismo de la glándula mamaria, la insulina ha recibido mayor atención debido a su estrecha relación con el metabolismo energético y proteico de los animales y debido al marcado efecto que ha mostrado tener sobre la producción y concentración de proteínas lácteas. Existen al menos tres mecanismos a través de los cuales esta hormona parece contribuir al incremento en la síntesis y concentración de proteínas lácteas, los cuales son revisados en este documento: distribución de nutrientes hacia la glándula mamaria, regulación en la expresión de genes de caseínas e incremento en la tasa de iniciación de la síntesis de las proteínas a nivel postranscripcional.
Descargas
Citas
Akers RM. Selection for Milk Production from a Lactation Biology Viewpoint. J Dairy Sci 2000; 83:1151-1158. DOI: https://doi.org/10.3168/jds.S0022-0302(00)74981-2
Amaral-Phillips DM, McGilliard AD, Lindberg GL, Veenhuizen JJ, Young JW. Effects of decreased availability of glucose for dairy cows. J Dairy Sci 1993; 76:752-761. DOI: https://doi.org/10.3168/jds.S0022-0302(93)77399-3
Bauman DE, Currie WB. Partitioning of nutrients during pregnancy and lactation: a review of mechanisms involving homeostasis and homeorhesis. J Dairy Sci 1980; 63:1514-529. DOI: https://doi.org/10.3168/jds.S0022-0302(80)83111-0
Bauman DE. Regulation of nutrient partitioning during lactation: homeostasis and homeorhesis revisited. In: Cronjé PB, editor. Ruminant physiology: digestion, metabolism, growth and reproduction. CAB International; 2000. p. 311-328. DOI: https://doi.org/10.1079/9780851994635.0311
Bequette BJ, Kyle CE, Crompton LA, Buchan V, Hanigan MD. Insulin regulates milk production and mammary gland and hind-leg amino acid fl uxes and blood fl ow in lactating goats. J Dairy Sci 2001; 84:241-255. DOI: https://doi.org/10.3168/jds.S0022-0302(01)74474-8
Bequette BJ, Kyle CE, Crompton LA, Anderson SE, Hanigan MD. Protein metabolism in lactating goats subjected to the insulin clamp. J Dairy Sci 2002; 85:1546-1555. DOI: https://doi.org/10.3168/jds.S0022-0302(02)74224-0
Brange J, Langkjoer L. Insulin structure and stability. Pharm Biotechnol 1993; 5:315-350.Choi YJ, Keller WL, Berg IE, Park CS, Mackinlay AG. Casein gene expression in bovine mammary gland. J Dairy Sci 1988; 71:2898-2903. DOI: https://doi.org/10.3168/jds.S0022-0302(88)79887-2
DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237: E214-223. DOI: https://doi.org/10.1152/ajpendo.1979.237.3.E214
Díaz DP, Burgos LC. ¿Cómo se transporta la glucosa a través de la membrana celular? Iatreia 2002; 15:179-189.Dimitrakoudis D, Vranic M, Klip A. Effects of hyperglycemia on glucose transporters of the muscle: use of the renal glucose reabsorption inhibitor phlorizin to control glycemia. J Am Soc Nephr 1992; 3:1078-1091. DOI: https://doi.org/10.1681/ASN.V351078
Freychet P. Pancreatic hormones. In: Baulieu E-E and Kelly PA editors. Hormones, from molecules to disease. London, UK: Hermann, publishers in arts and science; 1990. p. 491-532. DOI: https://doi.org/10.1007/978-94-011-3060-8_11
García JA. Hormonas: mensajeros químicos y comunicación celular. México DF: Fondo de Cultura Económica, SA de CV; 1998. 119 p.Gowen JW, Tobey ER. Studies on milk secretion: The Infl uence of Inanition. J Gen Physiol 1931; 15:45-66. DOI: https://doi.org/10.1085/jgp.15.1.45
Gowen JW, Tobey ER. On the mechanism of milk secretion: the infl uence of insulin and phloridzin. J Gen Physiol 1931; 15:67-85. DOI: https://doi.org/10.1085/jgp.15.1.67
Griinari JM, Mcguire MA, Dwyer DA, Bauman DE, Barbano DM et. al. The role of insulin in the regulation of milk protein synthesis in dairy cows. J Dairy Sci 1997; 80:2361-2371. DOI: https://doi.org/10.3168/jds.S0022-0302(97)76187-3
Gupta BBP, Lalchhandama K. Molecular mechanisms of glucocorticoid action. Current Sci 2002; 83:1103-1111.
Hanigan MD, Crompton LA, Metcalf JA, France J. Modelling mammary metabolism in the dairy cow to predict milk constituent yield, with emphasis on amino acid metabolism and milk protein production: model evaluation. J Theor Biol 2002, 217:311-330. DOI: https://doi.org/10.1006/jtbi.2002.3037
Harris B, Bachman KC. Nutritional and management factors affecting solids-not-fat, acidity and freezing point of milk. University of Florida, Institute of Food and Agricultural Sciences, Florida Cooperative Extension Service. 2003. 5 p.Hayirli A, Bertics SJ, Grummer R. Effects of slow-release insulin on production, liver triglyceride, and metabolic profi les of Holsteins in early lactation. J Dairy Sci 2002; 85:2180-2191. DOI: https://doi.org/10.3168/jds.S0022-0302(02)74297-5
Hiromi S, Sawa Y, Tsuyoshi T, Ken-Go H, Akio M, Seizo H, Masa T. Expression of glucose transporter 1 (GLUT1) and 4 (GLUT4) in bovine follicles and corpora lutea. Vancouver, Canada: 37th Annual meeting of the society for the study of reproduction, University of British Columbia. 2004. 1p.Hocquette J. F., Abe H. Facilitative glucose transporters in livestock species. Reprod Nutr Dev 2000; 40:517-533. DOI: https://doi.org/10.1051/rnd:2000134
Hood RL, Allen CE. Cellularity of bovine adipose tissue. J Lipid Res 1973; 14:605-610. DOI: https://doi.org/10.1016/S0022-2275(20)36840-1
Hua Q-X, Chu YC, Jia W, Phillips NF, Wang RY, et. al.. Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfi de pairing. J Biol Chem 2002; 277:43443-43453. DOI: https://doi.org/10.1074/jbc.M206107200
Hubbard SR, Till JH. Protein tyrosine kinase structure and function. Annu Rev Biochem 2000; 69:373-398.Johnston SL, Kitson KE, Tweedie JW, Davis SR, Lee J. y-Glutamyl transpeptidase inhibition suppresses milk protein synthesis in isolated ovine mammary cells. J Dairy Sci 2004; 87:321-329. DOI: https://doi.org/10.3168/jds.S0022-0302(04)73171-9
Kaneko JJ. Carbohydrate metabolism and its diseases. In: Kaneko J. J., Harvey JW, Bruss ML, editors. Clinical biochemistry of domestic animals. 5th edition. San Diego, Cal: Academic Press; 1997. p. 45-81. DOI: https://doi.org/10.1016/B978-012396305-5/50004-X
Komaragiri MVS, Erdman RA. Factors affecting body tissue mobilization in early lactation dairy cows. 1. Effect of dietary protein on mobilization on body fat and protein. J Dairy Sci 1997; 80:929-937. DOI: https://doi.org/10.3168/jds.S0022-0302(97)76016-8
Komatsu T, Itoh F, Kushibiki S, Hodate K. Changes in gene expression of glucose transporters in lactating and nonlactating cows. J Anim Sci 2005; 83:557-564. DOI: https://doi.org/10.2527/2005.833557x
Kuraishi T, Sun Y, Fugaku A, Imakawa K, Sakai S. The poly(A) tail length of casein mRNA in the lactating mammary gland changes depending upon accumulation and removal of milk. Biochem J 2000; 347:579-583. DOI: https://doi.org/10.1042/bj3470579
Léonard M, Burchard J, Gallo G, Block E. Effects of long term infusions of glucose and/or insulin in bST-treated cows before peak milk on nutrient and hormonal profi le. J Dairy Sci 1992; 75 (Suppl 1):182.
Mackle TR, Dwyer DA, Ingvartsen KL, Chouinard PY, Lynch JM, et. al. Effects of insulin and amino acids on milk protein concentration and yield from dairy cows. J Dairy Sci 1999; 82:1512-1524. DOI: https://doi.org/10.3168/jds.S0022-0302(99)75378-6
Mackle TR, Dwyer DA, Ingvartsen KL, Chouinard PY, Ross DA et. al. Effects of insulin and postruminal supply of protein on use of amino acids by the mammary gland for milk protein synthesis. J Dairy Sci 2000; 83:93-105. DOI: https://doi.org/10.3168/jds.S0022-0302(00)74860-0
McGuire MA, Griinari JM, Dwyer DA, Bauman DE. Role of insulin in the regulation of mammary synthesis of fat and protein. J Dairy Sci 1995; 78:816-824. DOI: https://doi.org/10.3168/jds.S0022-0302(95)76693-0
Mendivil CO, Sierra ID. Acción insulínica y resistencia a la insulina: aspectos moleculares. Rev Fac Med Univ Nac Col 2005; 53:235-243.Ministerio de Agricultura y Desarrollo Rural (MADR)- Resolución 0012, Sistema de pago de la leche cruda al productor- 2007.Molento CFM, Block E, Cue RI, Petitclerc D. Effects of insulin, recombinant bovine somatotropin, and their interaction on insulin-like growth factor-i secretion and milk protein production in dairy cows. J Dairy Sci 2002; 85:738-747. DOI: https://doi.org/10.3168/jds.S0022-0302(02)74131-3
Moo Choi K, Barash I, Rhoads RE. Insulin and Prolactin Synergistically Stimulate b-Casein Messenger Ribonucleic Acid Translation by Cytoplasmic Polyadenylation. Mol Endocrinology 2004; 18:1670-1686. DOI: https://doi.org/10.1210/me.2003-0483
Moorby JM, Dewhurst RJ, Tweed JKS, Dhanoa MS, Beck NFG. Effects of altering the energy and protein supply to dairy cows during the dry period. 2. Metabolic and hormonal responses. J Dairy Sci 2000; 83:1795-1805. DOI: https://doi.org/10.3168/jds.S0022-0302(00)75050-8
Morimoto S. Mecanismos moleculares que intervienen en la regulación de la síntesis de insulina por glucosa. Rev Hosp Gral Dr M Gea González 2000; 3:118-120.
National Dairy Council. Emerging health benefi ts of dairy proteins. Dairy Council Digest 2006; 77:19-24.
Nishimoto H, Matsutani R, Yamamoto S, Takahashi T, Hayashi K-G, et. al. Gene expression of glucose transporter (GLUT) 1, 3 and 4 in bovine follicle and corpus luteum. J Endocrinology 2006; 188:111-119. DOI: https://doi.org/10.1677/joe.1.06210
Proud CG. Regulation of protein synthesis by insulin. Biochem Soc Trans 2006; 34:213-216. DOI: https://doi.org/10.1042/BST0340213
Reynolds CK, Harmon DL, Cecava MJ. Absortion and delivery of nutrients for milk protein synthesis by portal drained viscera. J Dairy Sci 1994; 77:2787-2808. DOI: https://doi.org/10.3168/jds.S0022-0302(94)77220-9
Rosen JM, Wyszomierski SL, Darryl Hadsell. Regulation of milk protein gene expression. Annu Rev Nutr 1999; 19:407-436.Sakai T, Hamakawa M, Kubo S. Glucose and xylitol tolerance test for ketotic and healthy dairy cows. J Dairy Sci 1996; 79:372-377. DOI: https://doi.org/10.1146/annurev.nutr.19.1.407
Sasaki S. Mechanism of insulin action on glucose metabolism in ruminants. Animal Sci J 2002; 73:423-433.Schmidt GH. Effect of insulin on yield and composition of milk of dairy cows. J Dairy Sci 1966; 49:381-385. DOI: https://doi.org/10.1046/j.1344-3941.2002.00059.x
Shepherd PR, Withers DJ, Siddle K. Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling. Biochem J 1998; 333:471-490. DOI: https://doi.org/10.1042/bj3330471
Shepherd PR. Mechanisms regulating phosphoinositide 3-kinase signaling in insulin-sensitive tissues. Review. Acta Physiol Scand 2005; 183:3-12. DOI: https://doi.org/10.1111/j.1365-201X.2004.01382.x
Sohlström A, Forsum E. Changes in adipose tissue volume and distribution during reproduction in Swedish women as assessed by magnetic resonance imaging. Am J Clin Nutr 1995; 61:287-295. DOI: https://doi.org/10.1093/ajcn/61.2.287
Stoecklin E, Wissler M, Moriggl R, Groner B. Specifi c DNA binding of STAT5, but not of glucocorticoid receptor is required for their functional cooperation in the regulation of gene transcription. Mol Cell Biol 1997; 17:6708-6716. DOI: https://doi.org/10.1128/MCB.17.11.6708
Su X, Lodhi IJ, Saltiel AR, Stahl PD. Insulin-stimulated interaction between insulin receptor substrate 1 and p85{alpha} and activation of protein kinase B/Akt require Rab5 J Biol Chem 2006; 281:27982- 27990. DOI: https://doi.org/10.1074/jbc.M602873200
Sukkar SG, Bounous G. The role of whey protein in antioxidant defence. Riv Ital Nutri Parent Enter. 2004; 22:193-200.
Tucker HA. Hormones, mammary growth, and lactation: a 41-year perspective. J Dairy Sci 2000; 83:874-884. DOI: https://doi.org/10.3168/jds.S0022-0302(00)74951-4
Van Dam EM, Govers R, James DE. Akt activation is required at a late stage of insulin-induced GLUT4 translocation to the plasma membrane. Mol Endocrinology 2005; 19:1067-1077. DOI: https://doi.org/10.1210/me.2004-0413
Vonderhaar BK, Ziska SE. Hormonal regulation of milk protein gene expression. Annu Rev Physiol 1989; 51:641-652. DOI: https://doi.org/10.1146/annurev.ph.51.030189.003233
Wang J, Shen L, Najafi H, Kolberg J, Matschinsky FM, et. al. Regulation of insulin preRNA splicing by glucose. Proc Natl Acad Sci USA 1997; 94:4360-4365. DOI: https://doi.org/10.1073/pnas.94.9.4360
Williams SA, Blache D, Martin GB, Foot R, Blackberry MA, et. al. Effect of nutritional supplementation on quantities of glucose transporters 1 and 4 in sheep granulosa and theca cells. Reproduction 2001; 122: 947-956. DOI: https://doi.org/10.1530/rep.0.1220947
Wood IS, Trayhurn P. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr 2003; 89:3-9. DOI: https://doi.org/10.1079/BJN2002763
Xiao CT, Cant JP. Relationship Between Glucose Transport and Metabolism in Isolated Bovine Mammary Epithelial Cells. J Dairy Sci 2005; 88:2794-2805. DOI: https://doi.org/10.3168/jds.S0022-0302(05)72959-3
Zhao F-Q, Millera PJ, Walla EH, Zhenga Y-C, Donga B, et. al. Bovine glucose transporter GLUT8: cloning, expression, and developmental regulation in mammary gland. Bioch Bioph Acta 2004; 1680:103-113. DOI: https://doi.org/10.1016/j.bbaexp.2004.09.001
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2016 Revista Colombiana de Ciencias Pecuarias
![Creative Commons License](http://i.creativecommons.org/l/by-nc-sa/4.0/88x31.png)
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
Los autores permiten a RCCP reimprimir el material publicado en él.
La revista permite que los autores tengan los derechos de autor sin restricciones, y permitirá que los autores conserven los derechos de publicación sin restricciones.