El espermatozoide, desde la eyaculación hasta la fertilización
DOI:
https://doi.org/10.17533/udea.rccp.324099Palavras-chave:
acrosome reaction, activation, adhesion, capacitation, fusionResumo
Resumen
En los últimos años se ha hecho un inmenso progreso en el entendimiento de los mecanismos moleculares involucrados en la maduración del gameto masculino y su tránsito desde la gónada hasta la fertilización del oocito. A lo largo de este trayecto el espermatozoide modifica su morfología y sus componentes moleculares especialmente, y además ocurren procesos que conducen a la activación para la entrada al oocito, para activar a su vez los mecanismos que conducen a la formación del zigoto. Este artículo presenta, a partir de la interpretación de la literatura actual un modelo de los eventos que se suceden a partir de la eyaculación hasta la fertilización, con énfasis en los mecanismos celulares y moleculares conocidos, y señala algunos vacíos de información aún existentes.
Palabras clave: activación, adhesión, capacitación, fusión, reacción acrosomal.
Summary
During the last recent years there has been a great increase of information regarding the molecular mechanisms involved in the maturation of the male gamete as well as its progression from the gonad up to fertilizing the oocyte. Along this way the sperm completes its maturation adding some molecular components; additionally along this trail take place all the processes leading to activation of the sperm for the entrance into the oocyte to initiates molecular cascades for the formation of a zygote. This article, based on updated literature proposes a model that integrates known cellular and molecular interactions and pinpoints some steps still requiring further research.
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Referências
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