Paratuberculose bovina:� Não sabemos a real situação da doença no gado colombiano?
DOI:
https://doi.org/10.17533/udea.rccp.324313Palavras-chave:
enterite crónica em ruminates, MycobacteriumaviumparatuberculoseResumo
O Mycobacterium avium subespécie paratuberculose (Map) é o agente que provoca uma severa gastroenterite granulomatosa em ruminantes, conhecida como doença de Johne ou paratuberculose bovina, caracterizada pela apresentação de diarréia persistente e caquexia progressivo, acabou provocando a morte ss animais com menos de 6 meses são os mais suscetíveis a contrair a infecção por tuberculose através da ingestão de leite contaminado ou erva ou via a transmissão e não obstante o facto de o agente excretada nas fezes, não há sinais clínicos antes de 2 a 5 anos, enquanto que o período de incubação dura. Devido à falta de tratamento, qualquer medida de controle deve estar centrada na identificação de animais infectados através de testes de diagnóstico fiável, para identificar o agente antes do início dos sinais clínicos para evitar a disseminação da infecção para os animais do mesmo rebanho ou outros, se a venda de animais assintomáticos. A infecção é distribuída em todo o mundo e é responsável por grandes perdas econômicas para a produção da indústria bovina. Na nossa área, tem documentado a doença em rebanhos leiteiros no município de San Pedro de los Milagros (Antioquia), mas cree que existem muitas outras áreas infectadas, aquilo que é exigido pelo desenvolvimento de métodos eficazes de detecção, diagnóstico e controle de doenças. Nesta revisão, vai tratar dos aspectos relativos à paratuberculose bovina e, finalmente, destaca algumas perspectivas de investigação sobre esta doença
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Referências
..Abalos.P ..Actualidad.en.paratuberculosis ..Tecnol.Vet.2001;.7:9-11 .
..Amer.AO,.Swanson.MS ..A. phagosome.of.one’s.own:.a. microbial.guide.to.life.in.the.macrophage ..Curr.Opin.Microbiol.2002;.5:56-61 . DOI: https://doi.org/10.1016/S1369-5274(02)00286-2
..Astarie-Dequeker.C,.N’Diaye.E-N,.Le.Cabec.V,.Rittig.MG,.Prandi.J,.et al .. The.mannose.receptor.mediates.uptake.of.pathogenic.and.nonpathogenic.mycobacteria.and.bypasses.bactericidal.responses.in.human.macrophages ..Infect.Immun.1999;.67:469-477 . DOI: https://doi.org/10.1128/IAI.67.2.469-477.1999
..Aylward.WL ..Update.on.paratuberculosis:.Epidemiology.of.Johne’s.disease.and.the.biology.of.Mycobacterium.paratuberculosis ..Irish.Vet.J.2003;.56:565-574 .
..Bannantine.JP,.Stabel.JR ..Killing.of.Mycobacterium avium.subspecies.paratuberculosis. within.macrophages ..BMC.Microbiol.2002;.2:1471-2180 . DOI: https://doi.org/10.1186/1471-2180-2-2
..Begara-McGorum.I,.Wildblood.LA,.Clarke.CJ,.Connor.KM,.Stevenson.K,.et al ..Early.immunopathological.events.in.experimental.ovine.paratuberculosis ..Vet.Immunol.Immunopathol.1998;.63:265-287 . DOI: https://doi.org/10.1016/S0165-2427(98)00107-X
Begg DJ, Griffin JFT. Vaccination of sheep against M. paratuberculosis:.immune.parameters.and.protective.efficacy. Vaccine 2005; 23:4999–5008. DOI: https://doi.org/10.1016/j.vaccine.2005.05.031
Bielanski A, Algire J, Randall GCB. Surujballi O. Risk of transmission.of .Mycobacterium avium.ssp ..paratuberculosis.by . embryo. transfer. of . in . vivo. and. in . vitro. fertilized. bovine.embryos .. Theriogenology .. 2006;.66:260-266 . DOI: https://doi.org/10.1016/j.theriogenology.2005.11.010
..Blood. DC .. Diseases. caused. by. mycobacterium. spp ..Diseases. caused. by. bacteria. IV .. In:. Pocket. companion.to . veterinary. medicine .. London:. Baillere. Tindall;. 1999 .p330-31 .
..Bögli-Stuber.K,.Kohler.C,.Seitert.G,.Glanemann.B,.Antognoli.MC,.et al .. Detection.of.Mycobacterium avium.subspecies.paratuberculosis. in.Swiss.dairy.cattle.by.real-time.PCR.and.culture:.a. comparison.of.the.two.assays ..J.Appl.Microbiol.2005;.99:587-597 . DOI: https://doi.org/10.1111/j.1365-2672.2005.02645.x
..Bull.TJ,.Gilbert.SC,.Sridhar.S,.Linedale.R,.Dierkes.N,.et al ..A. novel.multi-antigen.virally.vectored.vaccine.against.Mycobacterium avium subspecies paratuberculosis. PLoS.ONE.2000;.2:e1229 .. DOI: https://doi.org/10.1371/journal.pone.0001229
..Bull.TJ,.Hermon-Taylor.J,. Pavlik.I,. El-Zaatari.F,. Tizard.M ..Characterization.of.IS900.loci.in.Mycobacterium avium.subsp ..paratuberculosis. and.development.of.multiplex.PCR.typing ..Microbiology.2000;.146:2185-2197 . DOI: https://doi.org/10.1099/00221287-146-9-2185
..Bull.TJ,.McMinn.EJ,.Sidi-Boumedine.K,.Skull.A,.Durkin.D,.et al. Detection and verification of Mycobacterium avium.subsp ..paratuberculosis.in.fresh.ileocolonic.mucosal.biopsy.specimens.from.individuals.with.and.without.Crohn’s.disease ..J.Clin.Microbiol.2003;.41:2915-2923 . DOI: https://doi.org/10.1128/JCM.41.7.2915-2923.2003
..Cernicchiaro. N, . Wells. SJ,. Janagama. H, . Sreevatsan. S ..Influence of type of culture medium on characterization of Mycobacterium avium. subsp ..paratuberculosis. subtypes ..J.Clin.Microbiol.2008;.46:145-149 . DOI: https://doi.org/10.1128/JCM.01769-07
Chacón O, Bermúdez LE, Barletta RG. Johne�s disease,Johne’s.disease,.inflammatory bowel disease, and mycobacterium paratuberculosis ..Annu.Rev.Microbiol.2004;.58:329-63 . DOI: https://doi.org/10.1146/annurev.micro.58.030603.123726
..Chamberlin.WM,.Naser.SA ..Integrating.theories.of.the.etiology.of.Crohn’s.disease.on.the.etiology.of.Crohn’s.isease:.questioning.the.hypotheses ..Med.Sci.Monit.2006;.12:RA27-33 .
..Chi.J,.VanLeeuwen.JA,.Weersink.A,.Keefe.GP .. Direct.production.losses.and.treatment.costs.from.bovine.viral.diarrhea.virus,.bovine.leucosis.virus,.Mycobacterium avium.subspecies.paratuberculosis,. and.Neospora cainum..Prev.Vet.Med.2002;.55:137-153 . DOI: https://doi.org/10.1016/S0167-5877(02)00094-6
..Chi.J,.VanLeeuwen.JA,.Weersink.A,.Keefe.GP ..Management. factors. related. to . seroprevalences. to.bovine. viral-diarrhoea. virus,. bovine-leukosis. virus,.Mycobacterium avium.subspecies.paratuberculosis,.and.Neospora caninum. in . dairy. herds. in . the. Canadian.Maritimes .. Prev.Vet.Med.2002;.55:57-68 . DOI: https://doi.org/10.1016/S0167-5877(02)00067-3
..Clarence.MF,.Paratuberculosis ..Enfermedad.de.Johne ..En:.El.manual.Merck.de.veterinaria ..4a.ed ..New.Jersey:.Merck.&.Co ..1993 ..p .462-63 .
..Clarke.CJ ..The.pathology.and.pathogenesis.of.paratuberculosis.in.ruminants.and.other.species ..J. Comp.Pathol.1997;.116:217-261 .21 ..Collins.M,.Manning.E ..Biology .. Johne ́s.Information.Center .. University.of.Wisconsin ..School.of.Veterinary.Medicine ..�citado.20.Abril.2006],.URL:.http://www.johnes.org/biology/general .html#1. DOI: https://doi.org/10.1016/S0021-9975(97)80001-1
..Collins.M ..Diagnosis.of.paratuberculosis ..Vet.Clin.North.Am.1996;.12:357-71 . DOI: https://doi.org/10.1016/S0749-0720(15)30411-4
..Crossley.BM,.Zagmutt-Vergara.FJ,.Fyock.TL,.Whitlock.RH,.Gardner.IA ..Fecal.shedding.of.Mycobacterium avium.subsp ..paratuberculosis. by.dairy.cows ..Vet.Microbiol.2005;.107:257-263 . DOI: https://doi.org/10.1016/j.vetmic.2005.01.017
..De.Juan.J,. Álvarez.J,. Romero.B,.Bezos.B,.Castellanos.E,.et al..Comparison of four different culture media for isolationComparison.of.four.different.culture.media.for.isolation.and.growth.of.type.II. and.type.I/III.Mycobacterium avium.subsp ..paratuberculosis. strains.isolated.from.cattle.and.goats ..Appl.Environ.Microbiol.2006;.72:5927-5932 . DOI: https://doi.org/10.1128/AEM.00451-06
..Ellingson.LEJ,.Cheville.CJ,.Brees.D,.Miller.MJ,.Cheville.NF .. AbsenceofAbsence.of.Mycobacterium avium.subspecies.paratuberculosis.components.from.Crohn’s.disease.intestinal.biopsy.tissues ..Clin.Med.Res.2003;.1:217-226 .2
..Ernst.JD,.Macrophage.receptors.for.Mycobacterium tuberculosis ..Infect.Immun.1998;.66:1277-1281 .
..Faries.CF,.Roussel.AJ,.Jordan.E, .Strokes.SR,.Magee.DD ..Paratuberculosis. of . dairy. cattle .. A. wasting. condition,.commonly. called. Johne ́s. disease .. Texas. Agricultural.extension. Service ..Texas. A&M. University. system ...L-5243 .. 2-99 .
..Finlay.BB,.Falkow.S ..Common.themes.in.microbial.pathogenicity.revisited,.Microbiol ..Mol.Biol.Rev.1997;.61:136-169 . DOI: https://doi.org/10.1128/mmbr.61.2.136-169.1997
..Fischer.OA,.Matlova.L,.Dvorska.L,.Svastova.P,.Peral.DL,.et al.. Beetles.as.possible.vectors.of.infections.caused.by.Mycobacterium.avium.species ..Vet.Microbiol.2004;.102:247-255 . DOI: https://doi.org/10.1016/j.vetmic.2004.06.005
..Fouad.AK.El-Zaatari,.Michael.SO,.David.YG ..Etiology.of.Crohn’s.disease:.the.role.of Mycobacterium avium paratuberculosis. Trends.Mol.Med.2001;.7:247-252 . DOI: https://doi.org/10.1016/S1471-4914(01)01983-9
..Góngora. OA,. Villamil. JC .. La. paratuberculosis. bovina.desde la óptica de la salud pública. Holstein Colomb 1999;.147:44-48 .32. González J, Guijo MV, Garcıa-Pariente C, Verna A, Corpa JM,.et al. Histopathological classification of lesionsHistopathological classification of lesions associated.with.natural.paratuberculosis.infection.in.cattle ..J.Comp.Path.2005;.133:184-196 . DOI: https://doi.org/10.1016/j.jcpa.2005.04.007
..Grant.IR,.Popea.CM,.O’Riordana.LM,.Ballb.HJ,.Rowe.MT .. Improved.detection.of.Mycobacterium avium. subsp ..paratuberculosis. in.milk.by.immunomagnetic.PCR ..Vet.Microbiol.2000;.77:369-378 . DOI: https://doi.org/10.1016/S0378-1135(00)00322-9
..Grant. IR .. Zoonotic. potential. of . Mycobacterium. avium.ssp ..paratuberculosis:. the. current. position ..J. Appl.Microbiol.2005;.98:1282-1293 . DOI: https://doi.org/10.1111/j.1365-2672.2005.02598.x
Griffiths TA, Rioux K, De Buck J. Sequence polymorphisms.in.a.surface.PPE.protein.distinguish.types.I,.II,.and.III.of.Mycobacterium avium. subsp ..paratuberculosis ..J.Clin.Microbiol.2008;.46:1207-1212 . DOI: https://doi.org/10.1128/JCM.02031-07
..Harish.KJ,.Kwang.IJ,.Vivek.K,.Paul.C,.Srinand.S ..Cytokine.responses.of.bovine.macrophages.to.diverse.clinical.Mycobacterium avium.subspecies.paratuberculosis.strains .. �Published.online.2006.February.14]. �citado.25.Abril.2006].URL:.http://www .biomedcentral .com/1471-2180/6/10.doi:.10 .1186/1471-2180-6-10.
..Harris.NB,.Barletta.RG ..Mycobacterium avium subsp. paratuberculosis in.Veterinary.Medicine ..Clin.Microbiol.Rev.2001;.4:489-512 .38 ..Hostetter. J, . Steadham. E, . Haynes. J, . Bailey. T, . Cheville.N .. Phagosomal. maturation. and. intracellular. survival. of.Mycobacterium avium. subspecies.paratuberculosis. in . J774.cells .. Comp.Immunol.Microbiol.Infect.Dis.2003;.26:269-283 . DOI: https://doi.org/10.1016/S0147-9571(02)00070-X
..Huda.A,.Jensen.HE ..Comparison.of.histopathology,.cultivation.of.tissues.and.rectal.contents,.and.Interferon-gamma. and. serum. antibody. responses. for. the. diagnosis. of.bovine.paratuberculosis .. J.Comp.Pathol.2003;.129:259-267 . DOI: https://doi.org/10.1016/S0021-9975(03)00042-2
..Jay.L .E ..Ellingson,.John.C ..Cheville,.Dominique.Brees,.Janice.M ..Miller,.et al ..Absence.of.Mycobacterium.avium.subspecies.paratuberculosis.Components.from.Crohn’s.disease.intestinal.biopsy.tissues ..Clin.Med.Res.2003;.1:217-226 . DOI: https://doi.org/10.3121/cmr.1.3.217
..Joel.DE ..Macrophage.receptors.for.Mycobacterium tuberculosis ..Infect.Immun.1998;.66:1277-1281 . DOI: https://doi.org/10.1128/IAI.66.4.1277-1281.1998
..Judge.J,.Kyriazakis.I,.Greig.A,.Allcroft.DJ,.Hutchings.MR ..Clustering.of.Mycobacterium avium.subsp ..paratuberculosis. in.rabbits.and.the.environment:.how.hot.is.a. hot.spot?.Appl.Environ.Microbiol.Appl.Environ.Microbiol.2005;.71:6033-6038 . DOI: https://doi.org/10.1128/AEM.71.10.6033-6038.2005
..Käferstein.FK ..Mycobacterium.avium.subsp ..paratuberculosis.a. human.pathogen?.The.arguments.pro.and.contra ..Food.Control.2001;.12:1 . DOI: https://doi.org/10.1016/S0956-7135(01)00037-8
..Khare.S,.Ficht.TA,.Santos.RL,.Romano.J,.Ficht.AR,.et al. Rapid.and.sensitive.detection.of.Mycobacterium avium. subsp ..paratuberculosis. in.bovine.milk.and.feces.by.a. combination.of.Immunomagnetic.Bead.Separation-Conventional.PCR.and.Real-Time ..J. Clin.Microbiol.2004;.42:1075-1081 . DOI: https://doi.org/10.1128/JCM.42.3.1075-1081.2004
..Kunze.ZM,.Portaels.F,.Mcfadden.JJ ..Biologically.distinct.subtypes.of.Mycobacterium avium. differ.in.possession ..J.Clin.Microbiol.1992;.30:2366-2372 .. DOI: https://doi.org/10.1128/jcm.30.9.2366-2372.1992
..Li.Lingling,.Bannantine.JP,.Zhang.Q,.Amonsin.A,.May.BJ,.et al .. The.complete.genome.sequence.of.Mycobacterium.avium.subspecies.paratuberculosis ..Proc.Nat.Acad.Sci.USA.2005;.102:12344-12349 ..47 ..Manning.EJB,.Collins.MT . Mycobacterium avium subsp. paratuberculosis:. el.patógeno,.su.patogenia.y. su.diagnóstico ..Rev.Sci.Tech.Off.Int.Epiz.2001;.20:133-150 . DOI: https://doi.org/10.1073/pnas.0505662102
..McKenna.SL,.Keefe.GP,.Tiwari.A,.VanLeeuwen.J,.Barkema.HW .. Johne’s disease in Canada part II: diseaseJohne’s.disease.in.Canada.part.II:.disease.impacts,.risk.factors,.and.control.programs.for.dairy.producers ..Can.Vet.J.2006;.47:1089-1099 .
..Mercado.M,.Cicuta.DS,.Boehringer.ME,.Silvia.I ..Paratuberculosis.en.el.Ganado.lechero.de.corrientes ..Cátedra.de.microbiología ..Facultad.de.Ciencias.veterinarias.UNNE ..En.línea ..�citado.3.mayo.2006].URL..http://www1 .unne .edu .ar/cyt/veterinarias/v-049 .pdf.
..Mishina.D,.Katsel.P,.Brown.ST,.Gilberts.EC,.Greenstein.RJ ..On.the.etiology.of.Crohn.disease ..Proc.Natl.Acad.Sci.USA.1996;.93:9816-9820 . DOI: https://doi.org/10.1073/pnas.93.18.9816
..Muskensa.J,.Bakkerb.D,.De.Boera.J,.Van.Keulen.L ..Paratuberculosis.in.sheep:.its.possible.role.in.the.epidemiology.of.paratuberculosis.in.cattle ..Vet.Microbiol.2001;.78:101-109 . DOI: https://doi.org/10.1016/S0378-1135(00)00281-9
..Palucka.K,.Banchereau.J .. How.dendritic.cells.and.microbes.interact.to.elicit.or.subvert.protective.immune.responses ..Curr.Opin.Immunol.2002;.14:420-431 . DOI: https://doi.org/10.1016/S0952-7915(02)00365-5
..Paustial.LM,.Zhu.X,.Sreevatsan.S,.Robbe-Austerman.S,.Kapur.V,.Bannantine.JP ..Comparative.genomic.analysis.of.Mycobacterium avium. subspecies.obtained.from.multiple.host.species ..BMC.Genomics.2008;.9:135,.URL:.http://www .biomedcentral .com/1471-2164/9/135. DOI: https://doi.org/10.1186/1471-2164-9-135
..Pavlik.I,. Matlovaa.L,.Bartl.J,.Svastovaa.P,.Dvorska.L ..et al .. Parallel.faecal.and.organ.Mycobacterium avium. subsp ..paratuberculosis. culture.of.different.productivity.types.of.cattle ..Vet.Microbiol.2000;.77:309-324 . DOI: https://doi.org/10.1016/S0378-1135(00)00316-3
..Ramírez.VN,.Gaviria.BG,.Restrepo.BLF,.Gómez.NC ..Diagnóstico.epidemiológico.referente.a. varias.patologías.de.bovinos.en.tres.haciendas.de.la.universidad.de.Antioquia ..Facultad.de.Ciencias.Agrarias,.Universidad.de.Antioquia ..En.línea ..�citado.1. mayo2006] ..URL:.http://kogi .udea .edu .co/articulos/Med_Bovina/proyecto%20diagn%F3stico.pdf.
..Robert.JG,.Michael.TC ..Emerging.pathogens:.is.Mycobacterium avium.subspecies.paratuberculosis.zoonotic?.www .thelancet .com.2004;.364:396-397.�online] ..�citado.23.Abril.2006] ..URL:.www .thelancet .com. DOI: https://doi.org/10.1016/S0140-6736(04)16781-0
..Rossiter.CJ,.Henning.WR ..Isolation.of.Mycobacterium paratuberculosis. from.thin.market.cows.at.slaughter .. J.Anim.Sci.2001;.79:113 .
..Schleig.PM,.Buergelt.CD,.Davis.JK,.Williams.E,.Monif.GR,.et al ..Attachment.of.Mycobacterium.avium.subspecies.paratuberculosis. to.bovine.intestinal.organ.cultures:.Method.development.and.strain.differences ..Vet.Microbiol.2005;.108:271-279 . DOI: https://doi.org/10.1016/j.vetmic.2005.04.022
..Schorey.JS,.Cooper.AM,.Macrophage.signaling.upon.micobacterial.infection:.the.MAP. kinases.lead.the.way ..Cell.Microbiol.2003;.5:133-142 . DOI: https://doi.org/10.1046/j.1462-5822.2003.00263.x
..Sigurðardottir.OG,.Valheim.M,.Press.CM .. EstablishmentEstablishment.of.Mycobacterium.avium.subsp ..paratuberculosis.infection.in.the.intestine.of.ruminants ..Adv.Drug.Deliv.Rev.2004;.56:819-834 . DOI: https://doi.org/10.1016/j.addr.2003.10.032
..Sockett.DC,.Carr.DJ,.Collins.MT ..Evaluation.of.conventional.and.radiometric.fecal.culture.and.a.commercial.DNA. probe.for.diagnosis.of.Mycobacterium paratuberculosis. infections.in.cattle ..Can.J. Vet.Res.1992;.56:148-153 .
..Soto.JP,.Kruze.J,. Leiva.S ..Aislamiento.de.Mycobacterium avium.subsp ..paratuberculosis.de.fecas.en.rebaños.lecheros.infectados mediante el Método de Cornell modificado. Arch. med. vet. � online] .. 2002;. 34:. 275-282 .. � citado. 20 .Abril.2006] ..UR L : h t t p : / / w w w . s c i e l o . c l / s c i e l o . p h p ? s c r i p t = s c i _arttext&pid=S0301-732X2002000200013&lng=es&nrm=iso. DOI: https://doi.org/10.4067/S0301-732X2002000200013
..Stabel.JR,.Transitions.in.immune.responses.to.Mycobacterium paratuberculosis,. Vet.Microbiol.2000;.77:465-473 . DOI: https://doi.org/10.1016/S0378-1135(00)00331-X
..Sweeney.RW ..Paratuberculosis.(Johne ́s.Disease) ..Vet.Clin.North.Am.Food.Anim.Pract.1996;.12:305-471 . DOI: https://doi.org/10.1016/S0749-0720(15)30408-4
..Tooker.BC,.Burton.JL,.Coussen.PM ..Survival.tactics.of.M paratuberculosis. in.bovine.macrophages.cells ..Vet.Immunol.Immunopathol.2002;.87:429-437 . DOI: https://doi.org/10.1016/S0165-2427(02)00065-X
..Turenne. CY,. Collins. DM,. Alexander. DC,. Behr. MA ..Mycobacterium avium subsp. paratuberculosisand.M. avium.subsp ..avium.are.independently.evolved.pathogenic.clones.of .a.much.broader.group.of .M. avium.organisms .. J.Bacteriol.2008;.190:2479-2487 . DOI: https://doi.org/10.1128/JB.01691-07
..Valentin. WP,. Goethe. R .. Pathogenesis. of .Mycobacterium avium.subspecies.paratuberculosis.infections.in.ruminants:. still. more. questions. than. answers .. Microbes.Infect.1999;.1:1121-1127 . DOI: https://doi.org/10.1016/S1286-4579(99)00203-8
..Vieira.OV,.Botelho.RJ,.Grinstein.S ..Phagosome.maturation:.aging.gracefully,.Biochem.J.2002;.366:689-704 . DOI: https://doi.org/10.1042/bj20020691
..Weiss.DJ,.Evanson.OA,.Deng.M,.Abrahamsen.MS ..Gene.expression.and.antimicrobial.activity.of.bovine.macrophages.in.response.to.Mycobacterium.avium. subsp ..Paratuberculosis. Vet.Pathol.2004;.41:326-337 .. DOI: https://doi.org/10.1354/vp.41-4-326
..Weiss.DJ,.Evanson.OA,.Moritz.A,.Deng.MQ,.Abrahamsen.MS ..Differential.responses.of.bovine.macrophages.to.Mycobacterium.avium.subsp ..paratuberculosis.and.Mycobacterium.avium. subsp ..Avium.. Infect.Immun.2002;.70:5556-5561 . DOI: https://doi.org/10.1128/IAI.70.10.5556-5561.2002
..Whan.L,.Grant.IR,.Ball.HJ,.Scott.R,.Rowe.MT ..Bactericidal.effect.of.chlorine.on.Mycobacterium.paratuberculosis. in.drinking.water .. Lett.Appl.Microbiol.2001;.33:227-231 . DOI: https://doi.org/10.1046/j.1472-765x.2001.00987.x
..Whitlock.R ..Buergelt.C ..Preclinical.and.clinical.manifestations.of.paratuberculosis.Vet.Clin.North.Am.1996;.12:345-56 . DOI: https://doi.org/10.1016/S0749-0720(15)30410-2
..William.MC,.Saleh.AN ..Integrating.theories.of.the.etiology.of.Crohn’s.disease.on.the.etiology.of.Crohn’s.disease:.questioning.the.hypotheses ..Med.Sci.Monit.2006;.12:RA27-33
..Woo.SR,.Czuprynski.CJ ..Tactics.of.Mycobacterium avium subsp. paratuberculosis. for.intracellular.survival.in.mononuclear.phagocytes ..J.Vet.Sci.2008;.9:1-8 . DOI: https://doi.org/10.4142/jvs.2008.9.1.1
..Woo. SR,. Sotos. J, . Hart. AP,. Barletta. RG,. Czuprynski.CJ .. Bovine. monocytes. and. a. macrophage. cell. line.differ. in . their. ability. to . phagocytose. and. support. the.intracellular. survival. of .Mycobacterium avium. subsp ..Paratuberculosis ..Vet. Immunol. Immunopathol. 2006;.110:109-120 . DOI: https://doi.org/10.1016/j.vetimm.2005.09.010
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