Contribuição dos modelos murinos e primatas ao estudo de doenças por arenavirus e febre hemorrágica
DOI:
https://doi.org/10.17533/udea.rccp.324453Palavras-chave:
arenavirus, inmunologia, modelos animais, LCMVResumo
O seguinte manuscrito é um capítulo inédito da minha tese doutoral, baseado em casos históricos e recentes sobre modelos animais, que foram apresentados na defesa da tese de Ph.D. em Ciências Veterinárias da Universidade de Wisconsin, em outubro de 2003. A atual mini revisão escrita em estilo de versão livre, enfatiza em algumas pedras angulares da inmunologìa como ciência. Graças ao uso do modelo murino infectado natural e experimentalmente com o vírus da Coriomeningitis Linfocítica (LCMV). Seria suficiente mencionar que foram outorgados dois prêmios Nobel de Medicina pelos descobrimentos realizados a través do uso deste modelo, para reconhecer a real importância do mesmo. Adicionalmente, vários laboratórios, entre eles o da Dra. Salvato, tem utilizado o modelo macaco Rhesus como um instrumento para desvelar os mistérios das febres hemorrágicas por arenavirus, e particularmente a fisiologia e patologia da doença de Lassa em humanos. Aqui eu indico algo do conhecimento gerado a través do estudo das duas infecções animais.
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