STRUCTURE AND LEISHMANICIDAL ACTIVITY OF LARNAXOLIDE A AND B, NEW WITHANOLIDESFROM LARNAX GLABRA(STANDL.) SAWYER
DOI:
https://doi.org/10.17533/udea.acbi.331559Keywords:
Larnax glabra, leishmanicidal activity, new compounds, Solanaceae, withanolidesAbstract
Two new withanolides, Larnaxolide A (1) and Larnaxolide B (2), were isolated from ethanolic extract of Larnaxglabra (Standl.) Sawyerís leaves. The structures of these compounds were established according to NMRexperiments (HMQC, HMBC, and COSY) and biogenetic aspects. These compounds shown a promisingleishmanicidal activity and reduced toxicity compared to another withanolides
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