Encefalitis límbica:  una revisión narrativa de la literatura

Rommel Augusto Andrade Carrillo; Betty Alejandra Cabrera Orrego

doi:10.17533/udea.iatreia.272

Authors

Rommel Andrade-Carrillo Dialéctica terapia https://orcid.org/0000-0002-6720-5508
Betty Alejandra Cabrera-Orrego Dialéctica terapia https://orcid.org/0000-0001-6616-0590

DOI:

https://doi.org/10.17533/udea.iatreia.272

Keywords:

Antibodies, Autoimmune Diseases, Limbic Encephalitis, Neurological Manifestations, Paraneoplastic Syndromes, Nervous System

Abstract

Limbic encephalitis is a disease included in the group of autoimmune encephalitis triggered by different factors, including paraneoplastic, infectious, and pharmacological, among others. The main symptoms are memory impairment, seizures, and psychiatric symptoms. This disease can cause severe neuropsychiatric and cognitive sequelae if not treated in a timely manner, and, if underdiagnosed, it can worsen the prognosis when an underlying unidentified tumor exists. Given the importance of this condition, we wrote this article to provide an update on the diagnostic and therapeutic approach for these patients, according to possible findings in imaging, serum, and cerebrospinal fluid studies. Antibody detection tests can be used to identify, according to the location of the antigen (cellular surface, intracelular or synaptic), the relationship with tumors, response to treatment and prognosis. In case of paraneoplastic encephalitis, the therapeutic approach includes specific oncological treatment, immunotherapy, and symptom management, generally simultaneously.

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Author Biographies

Rommel Andrade-Carrillo, Dialéctica terapia

General Physician, Dialéctica terapia, Medellín, Colombia.

Betty Alejandra Cabrera-Orrego, Dialéctica terapia

General Physician, Universidad de Antioquia, Medellín, Colombia.

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