Validación de nuevos inhibidores de los transportadores de membrana de la familia MmpL de Mycobacterium tuberculosis como agentes antimicrobianos con potencial terapéutico
DOI:
https://doi.org/10.17533/udea.iatreia.345540Keywords:
Mycobacterium tuberculosis, MmpL, cell envelope, inhibitors tuberculosisAbstract
La tuberculosis es un enfermedad infectocontagiosa que es transmitida principalmente por aerosoles en los que va contenido el Mycobacterium tuberculosis (Mtb). Este patógeno ha provocado a nivel mundial 10 millones de contagios y 1,5 millones de muertes en el 2019. En Colombia, hay una incidencia mayor que en el año 2018 con 27.31 casos por cada 100.000 habitantes en el 2019. Para tratar a los pacientes contagiados se ha propuesto un régimen de antibióticos de primera línea como la rifampicina, la isoniacida, etambutol y la pirazinamida por variados períodos de tiempo y con una efectividad de control del 85% de las personas infectadas. Pero se ha encontrado que se ha aumentado las formas resistentes a los antibióticos usados en la primera línea por lo cual se ha propuesto desarrollar nuevos agentes terapéuticos.
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