Basal Insulin and Lipids in Normoglycemic Adults: An Analytical Study, 2022
DOI:
https://doi.org/10.17533/udea.iatreia.329Keywords:
Endocrinology, Glycemia, Health Vulnerability, Insulin, LipidsAbstract
Introduction: Lipogenesis worsens the clinical evolution of insulin-resistant patients. Variations in lipemia could predict insulin resistance in normoglycemic individuals.
Objectives: To analyze the relationship between basal insulin and serum lipids in normoglycemic individuals.
Methodology: Analytical and cross-sectional study of secondary data from 3902 Mexican adults from the National Health and Nutrition Survey-2022. The variables were: basal insulin, total cholesterol (TC), triglycerides (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL), and the triglycerides/glucose ratio (TG/glucose). For data analysis, Spearman correlation and multiple linear regression were used.
Results: In men, basal insulin was moderately correlated with TC (Rho = 0.482; p < 0.001), TG (Rho = 0.401; p < 0.001), TG/glucose index (Rho = 0.418; p < 0.001), HDL (Rho = -0.443; p < 0.001), and had a low correlation with LDL (Rho = 0.302; p < 0.001). In women, the correlation was low with TC (Rho = 0.175; p < 0.001), TG (Rho = 0.156; p < 0.001), and LDL (Rho = 0.160; p < 0.001), and moderate with HDL (Rho = -0.402; p < 0.001) and TG/glucose index (Rho = 0.410; p < 0.001). In men, basal insulin increases 0.282 points per mg/dL of additional TC; 0.012 per mg/dL of TG; 0.146 points for LDL, while it decreases 0.427 per mg/dL of HDL. In women, it increases 0.264 points per mg/dL of additional TC, 0.590 per mg/dL of TG, 0.246 for LDL, and decreases 0.572 points per mg/dL of additional HDL.
Conclusions: In normoglycemic individuals, basal insulin levels are higher when lipid concentrations are increased, and these lipids may predict the increase in this hormone.
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