Implication of the inferior vena cava in the generation of reentry in the pectinate muscles

Authors

DOI:

https://doi.org/10.17533/udea.redin.n75a03

Keywords:

Pectinate muscles, inferior vena cava, anisotropic, atrial arrhythmia, reentry

Abstract


Atrial  fibrillation  (AF)  is  the  most  common  cardiac  arrhythmia  and  its  prevalence increases with age. The most dangerous and complex arrhythmias  are the result of a phenomenon known as reentry. In experimental studies,  the vena cava has been associated with ectopic activity that promotes the  generation of reentries. The changes caused by electrical remodeling in an  atrial myocyte action potential model (AP), coupled with an anatomically  realistic three-dimensional model of human atria with orientation fibers were  incorporated in this work. When applying an ectopic focus to the nearby  ostium of the inferior vena cava, a relationship between this activity and the  generation of reentries in the pectinate muscles is found. A functional reentry  repeated in time is favored by the pectinate muscles anatomy, the anisotropic  properties and the non-uniform distribution in the three-dimensional tissue.  The existence of a preferential conduction pathway facilitates the initiation  of  reentries  affecting  the  conduction  scheme.  Therefore,  the  capacity  of  induction and development of arrhythmias are found.

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Author Biographies

Andrés Paolo Castaño-Velez, Universidad de Caldas

Centro de Investigación, Innovación, Desarrollo y Transferencia de Tecnología (CI2DT2), Facultad de Ingeniería Profesor de investigación, Departamento de Sistemas e Informática

Carlos Alberto Ruiz-Villa, Universidad de Caldas

Centro de Investigación, Innovación, Desarrollo y Transferencia de Tecnología (CI2DT2), Facultad de Ingeniería Profesor de investigación, Departamento de Sistemas e Informática

 

Andrés Gaspar Castillo-Sanz, Pontificia Universidad de Salamanca

Profesor del Departamento de Ingeniería del Lenguaje, Sistemas Informáticos y Software.

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Published

2015-05-15

How to Cite

Castaño-Velez, A. P., Ruiz-Villa, C. A., & Castillo-Sanz, A. G. (2015). Implication of the inferior vena cava in the generation of reentry in the pectinate muscles. Revista Facultad De Ingeniería Universidad De Antioquia, (75), 15–23. https://doi.org/10.17533/udea.redin.n75a03