Calcium hydroxide as a clinical paradigm is surpassed by mineral trioxide aggregate (MTA)

Authors

  • Fanny Lucía Yepes-Delgado Universidad de Antioquia
  • César Augusto Castrillón-Yepes Universidad de Antioquia

Keywords:

Pulp therapy, Pul copping, Calcium hydroxide, Apexification, Pulpotomy, Mineral trioxide aggregate

Abstract


Introduction: as a result of scientific research, calcium hydroxide (CH) enjoyed a privileged position for several decades as a choice with high predictive abilities for pulp therapy. We are now witnessing the collapse of this paradigm due to the emergence of mineral trioxide aggregate (MTA) with its biocompatibility—an ability to stimulate mineralization—, antimicrobial properties, and other advantages that make it more successful in endodontic therapy. The objective of this topic review was to identify the uses of CH and MTA from 1995 to the present, in different clinical conditions. Methods: this review consisted of a comprehensive literature search in Medline, PubMed, and SciELO from 1995 to the present. It included titles, abstracts, full articles, systematic reviews, and meta-analysis related to CH and MTA. Results: a number of scientific studies highlight the properties of CH in pulp therapy; however, MTA has also been used and studied as a replacement material. Conclusions: according to research on this field, MTA can be used in the same situations for which CH is recommended, with better probabilities of success.

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Author Biographies

Fanny Lucía Yepes-Delgado, Universidad de Antioquia

Dentist. Specialist in Comprehensive Dentistry of the Adult. MEd. So-ciology of Education. Full Professor-Researcher, School of Dentistry, Universidad de Antioquia

César Augusto Castrillón-Yepes, Universidad de Antioquia

Dentist. Candidate to the clinical specialization in Comprehensive Den-tistry of the Adult with emphasis in Periodontics. Postgraduate Stu-dent and Researcher, School of Dentistry, Universidad de Antioquia.

References

Lasala A. Endodoncia. 4a ed. Barcelona: Salvat; 1992. p. 659.

Mondragón JD. Endodoncia. México. Nueva Editorial Interamericana; 1995. p. 250.

Alacam T, Görgül G, Ömürlü H. Evaluation of diagnostic radiopaque contrast materials used with calcium hydroxide. J Endod 1990; 16: 365.

Castagnola L. La conservación de la vitalidad de la pulpa en la operatoria dental. Buenos Aires: Junín; 1956; p. 143.

Torabinejad M, Rastegar AF, Kettering JD, Pit TR. Bacterial leakage of mineral trioxide aggregate as a root end filling material. J Endod 1995; 21(3): 109-112.

Juárez N, Monteiro C, Gomes I, Antunes E, Bernardelli N, Brandao R. Evaluación de la capacidad selladora del agregado trióxido mineral blanco de dos marcas comerciales y cemento Portland blanco en obturación retrógrada. Med Oral 2004; 4(2): 41-46.

Miñana-Gómez M. El agregado de trióxido mineral (MTA) en endodoncia. RCOE 2002; 7(3): 283-289.

Oliveira M, Xavier C, Demarco F, Pinheiro AL, Costa A, Pozza D. Comparative chemical study of MTA and Portland cements. Braz Dent J 2007; 18(1): 3-7.

Chacko V, Kurikose S. Human pulpal response to mineral trioxide aggregate (MTA): a histologic study. J Clin Pediatr Dent 2006; 30(3): 203-210.

Tanomaru M, Tanomaru J, Barros D, Watanabe E, Ito I. In vitro antimicrobial activity of endodontic sealers, MTA-based cements and Portland cement. J Oral Sci 2007; 49: 41-45.

Ochoa CA, Herrera C, Jiménez A. MTA: generalidades y usos en endodoncia. Pontificia Universidad Javeriana. Facultad de Odontología. Posgrado en Endodoncia. [Internet]. [Consultado 2012 Abr. 4]. Disponible en: http://www.javeriana.edu.co/academiapgendodoncia/i_a_revision33.html

Yepes F, Vélez F. El hidróxido de calcio en la odontología actual. Rev Fac Odontol Univ Antioq 1995; 7(1): 23-33.

Bergenholtz G, Horsted-Bindslev P, Reit C. Endodoncia: diagnóstico y tratamiento de la pulpa dental. México: Manual Moderno; 2007.

Costa CAS, Nascimento AB, Teixeira HM, Fontana UF. Response of human pulps capped with a self-etching adhesive system. Dent Mater 2001; 17: 230-240.

Bergenholtz G. Evidence for bacterial causation of adverse pulpal responses in resin-based dental restorations. Crit Rev Oral Biol Med 2000; 11(4): 467-480.

Cox CF, Sübay RV, Ostro E, Suzuki S, Suzuki SH. Tunnel defects in dentine bridges: their formation following pulp capping. Oper Dent 1996; 21(1): 4-11.

Tziafas D, Smith AJ, Lesot H. Designing new treatment strategies in vital pulp therapy. J Dent 2000; 28(2): 77-92.

Van Meerbeek B, De Munck J, Yoshida Y, Inoue S, Vargas M, Vijay P et al. Buonocore memorial lecture. Adhesion to enamel and dentin: current status and future challenges. Oper Dent 2003; 28: 215.

Oliveira MF, Pugach MK, Hilton JF, Watanabe LG, Marshall GW Jr. The influence of the smear layer on adhesion: a self-etching primer vs. a total-etch system. Dent Mater 2003; 19: 758-767.

Cehreli ZC, Stephan A, Sener B. Antimicrobial properties of self-etching primer-bonding systems. Oper Dent 2003; 28: 143-148.

Costa CAS, Oliveira MF, Giro EMA, Hebling G. Biocompatibility of resin-based materials used as pulpcapping agents. Int Endod J 2003; 36(12): 831-839.

Percinoto C, Castro AM, Pinto LM. Clinical and radiographic evaluation of pulpotomies employing calcium hydroxide and trioxide mineral aggregate. Gen Dent 2006; 54(4): 258-261.

Waterhouse PJ, Nunn JH, Withworth JM. An investigation of the relative efficacy of Buckley’s Formocresol and calcium hydroxide in primary molar vital pulp therapy. Br Dent J 2000; 188(1): 32-36.

Silva AF, Tarquinio SBC, Demarco FF, Piva E, Rivero ERC. The influence of haemostatic agents on healing of healthy human dental pulp tissue capped with calcium hydroxide. Int Endod J 2006; 39: 309-316.

Schröder U. Effects of calcium hydroxide containing pulp capping agents on pulp cell migration, proliferation and differentiation. J Dent Res 1985; 64(Spec Iss): 541-548.

Fava L, Saunders W. Calcium hydroxide pastes: classification and clinical indications. Int Endod J 1999; 32: 257-282.

Simon S, Bhat K, Francis R. Effect of four vehicles on the pH of calcium hydroxide and the release of calcium ion. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995; 80: 459-464.

Camejo-Suárez MV. Respuesta pulpar ante el recubrimiento pulpar directo. Acta Odontol Venez 1999; 37(3): 205-215.

Andreata AM, Loss C, Granordele MP, Neto R. Tratamiento conservador da pulpa através da curetagem pulpar. Arq Odontol 1999; 35: 55.

Rodríguez G, Álvarez M, García J, Arias S, Más Sarabia M. El hidróxido de calcio: su uso clínico en la endodoncia actual. Arch Méd Camagüey 2005; 9(3): s. p.

Tronstad L, Andreasen JO, Hasselgren G, Kristerson L, Riis I. pH changes in dental tissues after root canal filling with calcium hydroxide. J Endod 1981; 7(1): 17-21.

Tunc ES, Saroglu I, Sari S, Günhan O. The effect of sodium hypochlorite application on the success of calcium hydroxide pulpotomy in primary teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 102(2): e22-e26.

Ng FK, Messer LB. Mineral trioxide aggregate as a pulpotomy medicament: an evidence-based assessment. Eur Arch Paediatr Dent 2008; 9(2): 58-73.

Ainehchi M, Eslami B, Ghanbariha M, Saffar A. Mineral trioxide aggregate (MTA) and calcium hydroxide as pulp-capping agents in human teeth: a preliminary report. Int Endod J 2002; 36: 225-231.

Lu Y, Liu T, Li H, Pi G. Histological evaluation of direct pulp capping with a self-etching adhesive and calcium hydroxide on human pulp tissue. Int Endod J 2008; 41: 643-650.

Schroder U. A 2-year follow-up of primary molars, pulpotomized with a gentle technique and capped with calcium hydroxide. Scand J Dent Res 1978; 86(4): 273-278.

Kopel HM. Considerations for the direct pulp capping procedure in primary teeth: a review of the literature. ASDC J Dent Child 1992; 59(2): 141-149.

Maroto M, Barberia E, Planells P, Garcia Godoy F. Dentin bridge formation after mineral trioxide aggregate (MTA) pulpotomies in primary teeth. Am J Dent 2005; 18: 151-154.

Tziafas D, Pantelidou O, Alvanou A, Belibasakis G, Papadimitriou S. The dentinogenic effect of mineral trioxide agrégate (MTA) in short-term camping experiments. Int Endod J 2002; 35: 245-254.

European Society of Endodontology. Quality guidelines for endodontic treatment: consensus report of the European Society of Endodontology. Int Endod J 2006; 39: 921-930.

Plasschaert AJM. The treatment of vital pulp 1. Diagnossis and aetiology. Int Endod J 1983; 16: 108-114.

Stanley HR Criteria for standardizing and increasing creability of direct pulp capping studies Proceeding of symposium current concepts and controversies in vital pulp caping. Am J Dent 1998; 11(Spec Iss): S11-S16.

Camejo MV. Respuesta pulpar ante el recubrimiento pulpar directo - Revisión de la literatura. Acta Odontol Venez 1999; 37(3): 205-215.

Pitt Ford TR, Torabinejad M, Abedi HR, Backland LK, Kariyawasam SP. Mineral trioxide aggregate as a pulp capping material. J Am Dent Assoc 1996; 127: 1941-1944.

Eskandarizadeh A, Shahpasandzadeh MH, Shahpasandzadeh M, Torabi M, Parirokh M. A comparative study on dental pulp response to calcium hydroxide, white and grey mineral trioxide aggregate as pulp capping agents. J Conserv Dent 2011; 14(4): 351-355.

Leye Benoist F, Gaye Ndiaye F, Kane AW, Benoist HM, Farge P. Evaluation of mineral trioxide aggregate (MTA) versus calcium hydroxide cement (Dycal) in the formation of a dentine bridge: a randomised controlled trial. Int Dent J 2012; 62(1): 33-39.

Moretti ABS, Oliveira TM, Sakai VT, Santos CF, Machado MAAM, Abdo RCC. Mineral trioxide aggregate pulpotomy of a primary second molar in a patient with agenesis of the permanent successor. Int Endod J 2007; 40: 738-745.

Sari S, Sonmez D. Internal resorption treated with mineral trioxide aggregate in primary molar tooth: 18-month follow-up. J Endod 2006; 32(1): 69-71.

Holland R, Souza VMJN, Otoboni Filho JA, Bernabé PFE, Dezan E Jr. Reaction of rat connective tissue to implanted dentine tubes filled with mineral trioxide aggregate or calcium hydroxide. J Endod 1999; 25: 161-166.

ISO Dentistry-Preclinical Evaluation of Biocompatibility of Medical Devices Used in Dentistry. Test methods for dental materials. International Organization for Standardization, Technical report. Geneva: ISO; 1997.

Olsson H, Petersson K, Rohlin M. Formation of hard tissue barrier after pulp capping in humans: a systematic review. Int Endod J 2006; 39: 429-442.

Brasil K, De Franceschi C, Santangelo M. Uso del Pro RootTM MTA en perforaciones dentarias. Rev Fac Odontol (B. Aires) 2009; 24(56/57): 27-36.

Wu MK, Kontakiotis EG, Wesselink PR. Long-term seal provided by some root-end filling materials. J Endod 1998; 24: 557-560.

Keiser K, Johnson CC, Tipton DA. Cytotoxicity of mineral trioxide aggregate using human periodontal ligament fibroblasts. J Endod 2000; 26: 288-291.

Mitchell PJC, Pitt Ford TR, Torabinejad M, McDonald F. Osteoblast biocompatibility of mineral trioxide aggregate. Biomaterials 1999; 20: 167-173.

Camilleri J, Montesin FE, Di Silvio L, Pitt Ford TR. The chemical constitution and biocompatibility of accelerated Portland cement for endodontic use. Int Endod J 2005; 38: 834-842.

Koh ET, Pitt Ford TR, Torabinejad M, McDonald F. Mineral trioxide aggregate stimulates cytokine production in human osteoblasts. J Bone Miner Res 1995; 10S: S406.

Koh ET, McDonald F, Pitt Ford TR, Torabinejad M. Cellular response to mineral trioxide aggregate. J Endod 1998; 24: 543-547.

Moretti A, Sakai V, Oliveira T, Fornetti A, Santos C, Machado M et al. The effectiveness of mineral trioxide aggregate, calcium hydroxide and formocresol for pulpotomies in primary teeth. Int Endod J 2008; 41: 547-555.

Fagundes TC, Barata TJ E, Prakki A, Bresciani E, Pereira JC. Indirect pulp treatment in a permanent molar: Case report of 4-year follow-up. J Appl Oral Sci 2009; 17(1): 70-74.

Modena KC, Casas-Apayco LC, Atta MT, Costa CA, Hebling J, Sipert CR et al. Cytotoxicity and biocompatibility of direct and indirect pulp capping materials. J Appl Oral Sci 2009; 17(6): 544-554.

Gupta A, Sinha N, Logani A, Shah N. An ex vivo study to evaluate the remineralizing and antimicrobial efficacy of silver diamine fluoride and glass ionomer cement type VII for their proposed use as indirect pulp capping materials-Part I. J Conserv Dent 2011; 14(2): 113-116.

Sinha N, Gupta A, Logani A, Shah N. Remineralizing efficacy of silver diamine fluoride and glass ionomer type VII for their proposed use as indirect pulp capping materials-Part II (A clinical study). J Conserv Dent 2011; 14(3): 233-236.

Torabinejad M, Watson TF, Pitt Ford TR. Sealing ability of a mineral trioxide aggregate when used as a root end filling material. J Endod 1993; 19(12): 591-595.

Sarkar NK, Caicedo R, Ritwik P, Moiseyeva R, Kawashima I. Physicochemical basis of the biologic properties of mineral trioxide aggregate. J Endod 2005; 31(2): 97-100.

Accorinte ML, Holland R, Reis A, Bortoluzzi MC, Murata SS, Dezan E Jr. et al. Evaluation of mineral trioxide aggregate and calcium hydroxide cement as pulp-capping agents in human teeth. J Endod 2008; 34(1): 1-6.

Graham L, Cooper PR, Cassidy N, Nor JE, Sloan AJ, Smith AJ. The effect of calcium hydroxide on solubilisation of bio-active dentine matrix components. Biomaterials 2006; 27(14): 2865-2873.

Huang F-M, Tai K-W, Chou M-Y, Chang Y-C. Cytotoxicity of resin, zinc oxide-eugenol, and calcium hydroxide-based root canal sealers on human periodontal ligament cells and permanent V79 cells. Int Endod J 2002; 35(2): 153-158.

Huang T-H, Huei L DMS, Kao Ch-T, Evaluation of the genotoxicity of zinc oxide eugenol-based, calcium hydroxide-based, and epoxy resin-based root canal sealers by comet assay. J Endod 2001; 27(12): 744-748.

Rosenberg B, Murray PE, Namerow, K. The effect of calcium hydroxide root filling on dentin fracture strength. Dent Traumatol 2007; 23: 26-29.

Andreassen JO, Farik B, Munksgaard EC. Long term calcium hydroxide as a root canal dressing may increase risk of root fracture. Dent Traumatol 2002; 18:134-7.

Pashley DH, Sano H, Ciucchi B, Yoshiyama M, Carvalho RM. Adhesion testing of dentin bonding agents: a review. Dent Mater 1995; 11: 117-125.

Molander A, Reit C, Dahlen G, Kvist T Microbiological status of root-filled teeth with apical periodontitis. Int Endod J 1998; 31: 1-7.

Sjögren U, Figdor D, Persson S, Sundqvist G. Influence of infection at the time of root filling on the outcome of endodontic treatment of teeth with apical periodontitis. Int Endod J 1997; 30: 297-306.

Estrela C, Sydney GB, Bammann LL, Felipe O Jr. Mechanism of action of calcium and hydroxyl ions of calcium hydroxide on tissue and bacteria. Braz Dent J1995; 6: 85-90.

Estrela C, Pimenta FC, Ito IY, Bammann LL. In vitro determination of direct antimicrobial effect of calcium hydroxide. J Endod 1997; 24(1): 15-17.

Mohammadi Z, Dummer PM. Properties and applications of calcium hydroxide in endodontics and dental traumatology. Int Endod J 2011; 44(8): 697-730.

Sydney GB, Estrela C. The influence of root canal preparation on anaerobic bacteria in teth with asymptomatic apical periodontitis. Braz Endod J 1996; 1(1): 12-15.

Gomes B, Lilley JD, Drucker DB. Variation in the susceptibilities of components of the endodontic microflora to biomechanical procedures. Int Endod J 1996; 29: 235-241.

Tanomaru Filho M, Yamashita J, Leonardo M, da Silva L, Tanomaru J, Ito I. In vivo microbiological evaluation of the effect of biomechanical preparation of root canals using different irrigating solutions. J Appl Oral Sci. 2006;14(2):105-10.

Chaves ES, Jeffcoat MK, Ryerson CC, Snyder B. Persistent bacterial colonization of Porphyromonas gingivalis, Prevotella intermedia and Actinobacillus actinomycetemcomitans in periodontitis and its association with alveolar bone loss after 6 months of therapy. J Clin Periodontol 2000; 7: 897-903.

Solomon C, Chalfin H, Kellert M, Weseley P. The endodontic- periodontal lesion: a rational approach to treatment. J Am Dent Assoc 1995; 126(4): 473-479.

Gomes B, Montagner F, Bellocchio V, Zaia A, Ferraz C, Almeida J et al. Antimicrobial action of intracanal medicaments on the external root surface. J Dent 2009; 37: 76-81.

Ferraz CCR, Gomes BPFA, Zaia AA, Teixeira FB, Souza-Filho FJ. In vitro assessment of the antimicrobial action and mechanical ability of chlorhexidine gel as and endodontic irrigant. J Endod 2001; 27: 452-455.

White RR, Hays GL, Janer LR. Residual antimicrobial activity after canal irrigation with chlorhexidine. J Endod 1997; 23: 229-231.

Dametto FR, Ferraz CCR, Gomes B, Zaia AA, Teixeira FB, Souza-Filho FJ. In vitro assessment of the immediate and prolonged antimicrobial action of chlorhexidine gel as an endodontic irrigant against Enterococcus faecalis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 99: 768-772.

Siqueira Jr JF, Uzeda M. Intracanal medicaments: evaluation of the antibacterial effects of chlorhexidine, metronidazole, and calcium hydroxide associated with three vehicles. J Endod 1997; 22: 167-169.

Gomes B, Souza S, Ferraz C, Teixeira F, Zaia A, Valdrighi L et al. Effectiveness of 2% chlorhexidine gel and calcium hydroxide against Enterococcus faecalis in bovine root dentine in vitro. Int Endod J 2003; 36: 267-275.

Estrela C, Pesce HF. Chemical analysis of the liberation of calcium and hydroxyl ions from calcium hydroxide pastes in connective tissue in dog. Part I. Braz Dent J 1996; 7: 41-46.

Ballal V, Kundabala M, Acharya S, Ballal M. Antimicrobial action of calcium hydroxide, chlorhexidine and their combination on endodontic pathogens. Aust Dent J 2007; 52(2): 118-121.

Leonardo MR, Silva LAB, Utrilla LS, Leonardo RT, Consolaro A. Effect of intracanal dressings on repair and apical bridging of teeth with incomplete root formation. Endod Dent Traumatol 1993; 9(1): 25-30.

Estrela C, Bammann LL, Pimenta FC, Pécora JD. Control of microorganisms in vitro by calcium hydroxide pastes. Int Endod J 2001; 34(5): 341-345.

Orstavik D, Kerekes K, Molven O. Effects of extensive apical reaming and calcium hydroxide dressing on bacterial infection during treatment of apical periodontitis: a pilot study. Int Endod J 1991; 24: 1-7.

Orstavik D, Haapasalo M. Disinfection by endodontic irrigants and dressings of experimentally infected dentinal tubules. Endod Dent Traumatol 1990; 6: 142-149.

Safavi KE, Spangberg LS, Langeland K. Root canal dentinal tubule disinfection. J Endod 1990; 16: 207-210.

Vahdaty A, Ford TPR, Wilson RF. Efficacy of chlorhexidine in disinfecting dentinal tubules in vitro. Endod Dent Traumatol 1993; 9: 243-248.

Heling I, Sommer M, Steinberg D, Friedman M, Sela MN. Microbiological evaluation of the efficacy of chlorhexidine in a sustained-release device for dentin sterilization. Int Endod J 1992; 25: 15-19.

Heling I, Steinberg D, Kenig S, Gavrilovich I, Sela MN, Friedman M. Efficacy of a sustained-release device containing chlorhexidine and Ca(OH)2 in preventing secondary infection of dentinal tubules. Int Endod J 1992; 25: 20-24.

Sirén EJ, Haapasalo MPP, Waltimo TM, Ørstavik D. In vitro antibacterial effect of calcium hydroxide combined with chlorhexidine or iodine potassium iodide on Enterococcusfaecalis. Eur J Oral Sci 2004; 112(4): 326-331.

Evans M, Davies J, Sundqvist G, Figdor D. Mechanisms involved in the resistance of Enterococcus faecalis to calcium hydroxide. Int Endod J 2002; 35: 221-228.

Barnard D, Davies J, Figdor D. Susceptibility of Actinomyces israelii to antibiotics, sodium hypochlorite and calcium hydroxide. Int Endod J 1996; 29(5): 320-326.

çalişkan M, Sen B. Endodontic treatment of teeth with apical periodontitis using calcium hydroxide: a long-term study. Endod Dent Traumatol 1996, 12: 215-221.

Basrani B, Ghanem A, Tjäderhane L. Physical and chemical properties of chlorhexidine and calcium hydroxide-containing medications J Endod 2004; 30: 413-417.

Stuart KG, Miller CH, Brown CE, Newton CW. The comparative antimicrobial effect of calcium hydroxide. Oral Surg Oral Med Oral Pathol 1991; 72: 101-104.

Georgopoulou M, Kontakiotis E, Nakou M. In vitro evaluation of the effectiveness of calcium hydroxide and paramonochlorophenol on anaerobic bacteria from the root canal. Endod Dent Traumatol 1993; 9: 249-253.

Siqueira JF Jr, Lopes HP. Mechanisms of antimicrobial activity of calcium hydroxide: a critical review. Int Endod J 1999; 32: 361-369.

Peters LB, van Winkelhoff AJ, Buijs JF, Wesselink PR. Effects of instrumentation, irrigation and dressing with calcium hydroxide on infection in pulpless teeth with periapical bone lesions. Int Endod J 2002; 35: 13-21.

Wang JD, Hume WR. Diffusion of hydrogen ion and hydroxyl ion from various sources through dentine. Int Endod J 1988; 21: 17-26.

Nerwich A, Figdor D, Messer HH. pH changes in root dentin over a 4-week period following root canal dressing with calcium hydroxide. J Endod 1993; 19: 302-306.

Weiger R, de Lucena J, Decker HE, Lost C. Vitality status of microorganisms in infected human root dentine. Int Endod J 2002; 35: 166-171.

Haapasalo H, Sirén E, Waltimo T, Ørstavik D, Haapasalo M Inactivation of local root canal medicaments by dentine: in vitro study. Int Endod J 2000; 33: 126-31.

Tang G, Samaranayake LP, Yip H-K. Molecular evaluation of residual endodontic microorganisms after instrumentation, irrigation and medication with either calcium hydroxide or Septomixine. Oral Dis 2004; 10(6): 389-397.

Athanassiadis B, Abbott PV, Walsh LJ. The use of calcium hydroxide, antibiotics and biocides as antimicrobial medicaments in endodontics. Aust Dent J 2007; 52(1 Suppl): S64-S82.

Soriano C, Palmier R, Souto R, Escobar M, Vieira A. Endodontic therapy associated with calcium hydroxide as an intracanal dressing: microbiologic evaluation by the checkerboard DNA-DNA hybridization technique. J Endod 2005; 31(2): 79-83.

Leonardo MR, Leal J. Endodoncia. Tratamiento de conductos radiculares. 2.a ed. Buenos Aires: Editorial Médica Panamericana; 1994.

Bakland LK, Andreasen JO. Will mineral trioxide aggregate replace calcium hydroxide in treating pulpal and periodontal healing complications subsequent to dental trauma? A review. Dent Traumatol 2012; 28(1): 25-32.

Andreasen JO. Treatment of fractured and avulsed teeth. ASDC J Dent Child 1971; 38: 29-35.

Sjögren U, Figdor D, Persson S, Sundqvist G. Influence of infection at the time of root filling on the outcome of endodontic treatment of teet with apical periodontitis. Int Endod J 1997; 30: 297-306.

Peters L, Wesselink P. Periapical healing of endodontically treated teeth in one and two visits obturated in the presence or absence of detectable microorganisms. Int Endod J 2002, 35: 660-667.

Caviedes-Bucheli J, Lombana N, Azuero-Holguin MM, Munoz HR. Quantification of neuropeptides (calcitonin gene-related peptide, substance P, neurokinin A, neuropeptide Y and vasoactive intestinal polypeptide) expressed in healthy and inflamed human dental pulp. Int Endod J 2006; 39(5):394-400.

Haapasalo M, Orstavik D. In vitro infection and disinfection of dentinal tubules. J Dent Res 1987; 66: 137-159.

Distel J, Hatton J, Gillespie J. Biofilm formation in medicated root canals. J Endod 2002, 28: 689-693.

Simon S, Bhat K, Francis R. Effect of four vehicles on the pH of calcium hydroxide and the release of calcium ion. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995; 80: 459-464.

Siqueira J, Uzeda M. Influence of different vehicles on the antibacterial effects of calcium hydroxide. J Endod 1998; 24: 663-665.

Ozcelik B, Tasman F, Ogan C. A comparison of the surface tension of calcium hydroxide mixed with different vehicles. J Endod 2000; 26: 500-502.

Fava L, Saunders W. Calcium hydroxide pastes: classification and clinical indications. Int Endod J 1999; 32: 257-282.

Weisenseel J, Hicks L, Pelleu G. Calcium hydroxide as an apical barrier. J Endod 1987; 13: 1-5.

Tziafas D, Economides N. Formation of crystals on the surface of calcium hydroxide containing materials in vitro. J Endod 1999; 25: 539-542.

Cvek M. Prognosis of luxated non-vital maxillary incisors treated with calcium hydroxide and filled with gutta percha. Endod Dent Traumatol 1992; 8: 45-55.

Al-Jundi SH. Type of treatment, prognosis and estimation of time spent to manage dental trauma in late presentation cases at a dental teaching hospital: a longitudinal and retrospective study. Dent Traumatol 2004; 20: 1-5.

Goel M, Bala S, Sachdeva G, Shweta. Comparative evaluation of MTA, calcium hydroxide and portland cement as a root end filling materials: a comprehensive review. Indian J Dent Sci 2011; 3(5): 212-217.

Hakki S, Bozkurt SB, Ozcopur B, Purali N, Belli S. Periodontal ligament fibroblast response to root perforations restored with different materials-a laboratory study. Int Endod J 2012; 45(3): 240-248.

Soares JA, Queiroz CE. Patogenesia periapical: aspectos clínicos, radiográficos e tratamento da reabsorção óssea e radicular de origem endodôntica. J Bras Endod 2001; 2: 124-135.

Felippe WT, Felippe MC, Rocha MJ. The effect of mineral trioxide aggregrated on the apexification and periapical healing of teeth with incomplete root formation. Int Endod J 2006; 39: 2-9.

Rosenberg B, Murray PE, Namerow, K. The effect of calcium hydroxide root filling on dentin fracture strength. Dent Traumatol 2007; 23: 26-29.

American Association of Endodontists. Recommended guidelines for treatment of the avulsed tooth. J Endod 1983; 9: 571.

Leonardo MR. Endodontia: tratamento dos canais radiculares-principios técnicos e biológicos. Art Med 2005; 1: 1215-1240.

Soares JA, Santos S, Silveira F, Nunes E. Nonsurgical treatment of extensive cyst-like periapical lesion of endodontic origin. Int Endod J 2006; 39: 566-575.

Çalişkan M K, Türkün M. Periapical repair and apical closure of a pulpless tooth using calcium hydroxide. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 84(6): 683-687.

Vellore KG. Calcium hydroxide induced apical barrier in fractured nonvital immature permanent incisors. J Indian Soc Pedod Prev Dent 2010; 28(2): 110-112.

Chala S, Abouqal R, Rida S. Apexification of immature teeth with calcium hydroxide or mineral trioxide aggregate: systematic review and meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 112(4): e36-42.

Morse D, O’Larnic J, Yesilsoy C. Apexification: review of the literature. Quintessence Int 1990; 21: 589-598.

Shabahang S, Torabinejad M, Boyne P, Abedi H, McMillan P. A comparative study of root-end induction using osteogenic protein-1, calcium hydroxide, and mineral trioxide aggregate in dogs. J Endod 1999; 25: 1-5.

Smith J, Leeb I, Torney D. A comparison of calcium hydroxide and barium hydroxide as agents for inducing apical closure. J Endod 1984; 10: 64-70.

Meligy OAS, Avery DR. Comparison of apexification with mineral trioxide aggregate and calcium hydroxide. Am Pediatr Dent 2006; 28(3): 248-253.

Lee YL, Lee BS, Lin FH, Yun Lin A, Lan WH, Lin CP. Effects of physiological environments on the hydration behavior of mineral trioxide aggregate. Biomaterials 2004; 25(5): 787-793.

Nair PN, Duncan HF, Pitt Ford TR, Luder HU. Histological, ultrastructural and quantitative investigations on the response of healthy human pulps to experimental capping with mineral trioxide aggregate: a randomized controlled trial. Inter Endod J 2008; 41: 128-150.

Faraco IM Jr. Holland R. Response of the pulp of dogs to capping with mineral trioxide aggregate or a calcium hydroxide cement. Dent Traumatol 2001; 17: 163-166.

Menezes R, Bramante CM, Letra A, Carvalho VG, García RB. Histologic evaluation of pulpotomies in dog using two types of mineral trioxide aggregate and regular and white Portland cements as wound dressing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004; 98: 376-379.

Aeinehchi M, Dadvand S, Fayazi S, Bayat-Movahed S. Randomized controlled trial of mineral trioxide aggregate and formocresol for pulpotomy in primary molar teeth. Int Endod J 2007; 40: 261-267.

Barrieshi-Nusair KM, Qudeimat MA. A prospective clinical study of mineral trioxide aggregate for partial pulpotomy in cariously exposed permanent teeth. J Endod 2006; 32: 731-735.

Eidelman E, Holan G, Fuks AB. Mineral trioxide aggregate vs. formocresol in pulpotomized primary molars: a preliminary report. Pediatr Dent 2001; 23: 15-18.

Moretti ABS, Oliveira TM, Sakai VT, Santos CF, Machado MA, Abdo RCC. Mineral trioxide aggregate pulpotomy of a primary second molar in a patient with agenesis of the permanent successor. Int Endod J 2007; 40: 738-745.

Sari S, Sonmez D. Internal resorption treated with mineral trioxide aggregate in primary molar tooth: 18-month follow-up. J Endod 2006; 32: 69-71.

Chacko V, Kukirose S. Human pulpal response to mineral trioxide aggregate (MTA): a histologic study. J Clin Pediatr Dent 2006; 30: 203-210.

Torabinejad M, Chivian N. Clinical applications of mineral trioxide aggregate. J Endod 1999; 25: 197-205.

Torneck C, Moe H, Howley T. The effect of calcium hydroxide on porcine pulp fibrobasts in vitro. J Endod 1983, 9: 131-136.

Cvek M, Granath P, Cleaton J, Austin J. Hard tissue barrier fomation in pulpotomized monkey teeth capped with cyanocrylate or calcium hydroxide for 10 and 60 minutes. J Dent Res 1985; 66: 1166-1174.

Güzeler I, Uysal S, Cehreli ZC. Management of trauma-induced inflammatory root resorption using mineral trioxide aggregate obturation: two-year follow up. Dent Traumatol 2010; 26(6): 501-504.

Marão HF, Panzarini SR, Aranega AM, Sonoda CK, Poi WR, Esteves JC et al. Periapical tissue reactions to calcium hydroxide and MTA after external root resorption as a sequela of delayed tooth replantation. Dent Traumatol 2011; 8(4): 306-313.

Cunha RS, Abe FC, Araujo RA, Fregnani ER, Bueno CE. Treatment of inflammatory external root resorption resulting from dental avulsion and pulp necrosis: clinical case report. Gen Dent 2011; 59(3): e101-6104.

Asgary S, Nosrat A, Seifi A. Management of inflammatory external root resorption by using calcium-enriched mixture cement: a case report. J Endod 2011; 37(3): 411-413.

Tronstad L. Root resorption-etiology, terminology and clinical manifestations. Endod Dent Traumatol 1988, 4: 241-252.

Siqueira J, Lopes H, Uzeda M. Recontamination of coronally unsealed root canals medicated with camphorated paramonochlorophenol or calcium hydroxide pastes after saliva challenge. J Endod 1998; 24: 11-14.

Nerwich A, Figdor D, Messer H. pH changes in root dentine over a 4-week period following root canal dressing with calcium hydroxide. J Endod 1993; 19: 302-306.

Wang J, Hume W. Diffusion of hydrogen ion and hydroxil ion from various sources through dentine. Int Endod J 1988; 21: 17-26.

Ozcelik B, Tasman F, Ogan C. A comparison of the surface tension of calcium hydroxide mixed with different vehicles. J Endod 2000; 26: 500-502.

Wedenberg C, Zetterqvist L. Interna resorption in human teeth: a histological, scanning electron microscope and enzyme histo-chemical study. J Endod 1987; 13: 255-259.

Cotti E, Lusso D, Dettori C. Management of apical inflammatory root resorption: report of a case. Int Endod J 1998; 31: 301-304.

Hammarstrom L, Blomlof L, Feiglin B, Lindskog S. Effect of calcium hydroxide treatment of periodontal repair and root resorption. Endod Dent Traumatol 1986; 2: 184-189.

Ardila Medina CM. Hipersensibilidad dentinal: Una revisión de su etiología, patogénesis y tratamiento. Av. Odontoestomatol 2009; 25 (3): 137-146.

Hargreaves KM, Goodis HE, Seltzer S (eds.). Seltzer and bender’s dental pulp. Dentin Formation and Repair. Chicago: Quintessence Publishing; 2012.

Wolfart S, Wegner SM, Kern M. Comparison of using calcium hydroxide or a dentine primer for reducing dentinal pain following crown preparation: a randomized clinical trial with an observation time up to 30 months. J Oral Rehabil 2004; 31(4): 344-350.

Trowbridge HO, Silver DR. A review of current approaches to in-office management of tooth hypersensitivity. Dent Clin North Am 1990; 34: 561.

Lang NP. Checkliste Zahnärztliche Behandlungsplanung, 2.a ed. Stuttgart: Georg Thieme Verlag; 1988: 214.

Strub JR, Türp JC, Witkowski S, Hürzeler MB, Kern M. Curriculum Prothetik I. Geschichte-Grundlagen-Behandlungskonzept-Vorbehandlung, 2.a ed. Berlin: Quintessenz; 1999.

Brännström M, Aström A. The hydrodynamics of the dentine: it’s possible relationship to dentinal pain. Int Dent J 1972; 22: 219.

Mash LK, Beninger CK, Bullard JT, Staffanou RS. Leakage of various types of luting agents. J Prosthet Dent 1991; 66: 763.

Bergenholtz G, Cox CF, Loesche WJ, Syed SA. Bacterial leakage around dental restorations: its effect on the dental pulp. J Oral Pathol 1982; 11: 439.

Bergenholtz G, Reit C. Reactions of the dental pulp to microbial provocation of calcium hydroxide treated dentin. Scand J Dent Res 1980; 88: 187.

Wolfart S, Wegner SM, Kern M. Comparison of using calcium hydroxide or a dentine primer for reducing dentinal pain following crown preparation: a randomized clinical trial with an observation time up to 30 months. J Oral Rehabil 2004; 31(4): 344-350.

Johnson GH, Lepe X, Bales DJ. Crown retention with use of a 5% glutaraldehyde sealer on prepared dentin. J Prosthet Dent 1998; 79: 671.

Wolfart S, Linnemann J, Kern M. Crown retention with use of different sealing systems on prepared dentin. J Oral Rehabil 2003; 30: 1053.

Pashley DH, Kalathoor S, Burnham D. The effects of calcium hydroxide on dentin permeability. J Dent Res 1986; 65: 417.

Lang NP. Checkliste Zahnärztliche Behandlungsplanung, 2.a ed. Stuttgart: Georg Thieme Verlag; 1988: 214.

Strub JR, Türp JC, Witkowski S, Hürzeler MB, Kern M. Curriculum Prothetik I. Geschichte-Grundlagen-Behandlungskonzept-Vorbehandlung, 2.a ed. Berlin: Quintessenz; 1999.

Levin MP, Yearwood LL, Carpenter WN. The desensitizing effect of calcium hydroxide and magnesium hydroxide on hypersensitive dentin. Oral Surg Oral Med Oral Pathol 1973; 35: 741.

Green BL, Green ML, McFall WT. Calcium hydroxide and potassium nitrate as desensitizing agents for hypersensitive root surfaces. J Periodontol 1977; 48: 667.

Bartold PM. Dentinal hypersensitivity: a review. Aust Dent J 2006 Sep; 51(3): 212-218.

McFall WT. A review of the active agents available for treatment of dentinal hypersensitivity. Endod Dent Traumatol 1986; 2: 141-149.

Scherman A, Jacobsen PL. Managing dentin hypersensitivity: what treatment to recommend to patients. J Am Dent Assoc 1992; 123: 57-61.

Nerwich A, Figdor D, Messer H. pH changes in root dentine over a 4-week period following root canal dressing with calcium hydroxide. J Endod 1993; 19: 302-306.

Miñana M, Carnes D, Walker III W. pH changes at the surface of root dentin after intracanal dressing with calcium oxide and calcium hydroxide. J Endod 2001, 27: 43-45.

Caviedes Bucheli J, Muñoz HR, Meneses JP. El paradigma del hidróxido de calcio en endodoncia: ¿sustancia milagrosa? Pontificia Universidad Javeriana. Facultad de Odontología. Posgrado en Endodoncia. [en línea] 2006. Disponible en: http://dentalexperience.es.tl/HIDROXIDO-DE-CALCIO-controversia.htm

Published

2014-01-14

How to Cite

Yepes-Delgado, F. L., & Castrillón-Yepes, C. A. (2014). Calcium hydroxide as a clinical paradigm is surpassed by mineral trioxide aggregate (MTA). Revista Facultad De Odontología Universidad De Antioquia, 25(1), 176–207. Retrieved from https://revistas.udea.edu.co/index.php/odont/article/view/11166

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