ACTIVITY AND EFFECTS OF UREASE AND ARGININE DEIMINASE IN SALIVA AND HUMAN ORAL BIOFILM

Authors

  • Évelyn Reyes-Beltrán Universidad de Chile
  • Javier Martín-Casielles Universidad de Chile
  • Ismael Yevenes-López Universidad de Chile
  • Miguel Neira-Jara Universidad de Chile
  • Patricia Palma-Fluxá Universidad de Chile
  • Valeria Gordan-Veiga University of Florida
  • Gustavo Moncada-Cortés Universidad de Chile

Keywords:

ammonium, urease, arginine deiminase, saliva, biofilm, dental caries

Abstract


The purpose of this review is to present the emerging findings on the potential anti-cariogenic properties of the bioactive molecules of oral metabolism related with ammonia production. The literature analysis supports a new preventive dimension in the knowledge of dental caries disease by studying the published evidence provided by in vitro and clinical studies, in which the ammonia produced from urea and arginine in the oral environment represents an important endogenous inhibitory factor in the development of dental caries lesions. This fact would support the hypothesis that ammonia production by urease and the arginine deiminase system could potentially inhibit the development of dental caries by neutralizing acids and stabilizing the oral microbiota, thus enhancing the conditions for oral health maintenance. This review presents studies on the oral enzyme activity which may constitute a promising field in the definition of new lines of research in cariology, particularly in vivo and in situ, amed at establishing the effectiveness and clinical application of these compounds in the prevention of dental caries.

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Author Biographies

Évelyn Reyes-Beltrán, Universidad de Chile

Operative Dentistry, School of Dentistry, Universidad de Chile

Javier Martín-Casielles, Universidad de Chile

Operative Dentistry, School of Dentistry, Universidad de Chile

Ismael Yevenes-López, Universidad de Chile

Chemistry, School of Dentistry, Universidad de Chile

Miguel Neira-Jara, Universidad de Chile

Chemistry, School of Dentistry, Universidad de Chile

Patricia Palma-Fluxá, Universidad de Chile

Microbiology, School of Dentistry, Universidad de Chile

Valeria Gordan-Veiga, University of Florida

Operative Dentistry Department, College of Dentistry, University of Florida, Gainesville, FL, USA

Gustavo Moncada-Cortés, Universidad de Chile

Operative Dentistry, School of Dentistry, Universidad de Chile

Published

2012-06-20

How to Cite

Reyes-Beltrán, Évelyn, Martín-Casielles, J., Yevenes-López, I., Neira-Jara, M., Palma-Fluxá, P., Gordan-Veiga, V., & Moncada-Cortés, G. (2012). ACTIVITY AND EFFECTS OF UREASE AND ARGININE DEIMINASE IN SALIVA AND HUMAN ORAL BIOFILM. Revista Facultad De Odontología Universidad De Antioquia, 23(2), 343–352. Retrieved from https://revistas.udea.edu.co/index.php/odont/article/view/8748

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