Parâmetros de estresse oxidativo em cães naturalmente infectados com sarna sarcóptica
DOI:
https://doi.org/10.17533/udea.rccp.v36n4a2Palavras-chave:
biomarcador, estresse oxidativo, infestação, cachorro, Sarcoptes, sarna sarcóptica, sarna, zoonoseResumo
Antecedentes: A sarna é uma das doenças mais comuns em cães, e também ameaça a saúde humana e animal devido ao seu caráter zoonótico. Objetivo: O objetivo da pesquisa foi estudar o equilíbrio oxidante/antioxidante com achados hematológicos em cães infestados com sarna sarcóptica. Métodos: Os cães do grupo Sarcoptes apresentavam sinais de infestação como prurido intenso, escoriações, alopecia e bolhas no cotovelo e margens auriculares. O material deste estudo consistiu em 32 cães sem raça definida, entre 1 e 2 anos de idade. Os cães foram divididos em dois grupos que foram grupo controle (animais livres de infestação, n=10), bem como o grupo sarna sarcóptica (Sarcoptes; n=22). Resultados: Os resultados do estudo demonstraram que houve aumentos significativos (p<0,01) no total oxidant status (TOS), malondialdeído (MDA), oxidative stress index (OSI) e nos níveis de óxido nítrico (NO), enquanto glutationa (GSH) e os níveis de status antioxidante total (TAS) dos cães infestados por Sarcoptes diminuíram significativamente (p<0,01). Além disso, foi encontrado um aumento significativo (p<0,01) da contagem de leucócitos dos cães do grupo Sarcoptes em comparação com o controle. Por outro lado, houve reduções significativas (p <0,01) nas contagens de RBC, HGB e PCV em cães infestados por Sarcoptes. Conclusões: Pode-se sugerir uma possível associação entre desequilíbrio oxidante/antioxidante e achados hematológicos nos cães infestados por sarna sarcóptica. Além disso, além dos marcadores MDA, TAS, TOS e OSI, NO e GSH também podem ser usados para descobrir o estresse oxidativo em cães naturalmente infectados por Sarcoptes scabiei.
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