Caracterização de laudos de aspirados de medula óssea em cães e gatos: estudo retrospectivo

Autores

DOI:

https://doi.org/10.17533/udea.rccp.v38n2a9

Palavras-chave:

animais de estimação, aspirados de medula óssea, doenças do cão, doenças do gato, hematologia, hiperplasia, medula óssea, neoplasias

Resumo

Antecedentes: A aspiração da medula óssea permite o estudo, estadiamento e monitorização de múltiplas entidades com envolvimento medular; O laudo é componente essencial da etapa posanalítica e os itens estabelecidos por cada instituição influenciam significativamente o entendimento e a tomada de decisão do médico assistente. Objetivo: Descrever as características zoográficas, clínicas e de qualidade, bem como a frequência dos diagnósticos e seus fatores associados nos relatos de aspirados de medula óssea de cães e gatos atendidos em centros veterinários na Colômbia durante o período 2012-2023. Métodos: Estudo descritivo transversal. Dos laudos de aspirados de medula óssea e das interconsultas, foram extraídas variáveis ​​zoográficas e clínicas e determinadas a frequência dos diagnósticos e os fatores associados a eles. A adesão às variáveis ​​de qualidade do relato foi avaliada por meio de diretrizes contrastantes para o relato de aspirados de medula óssea em cães, gatos e humanos. Resultados: De 8 instituições veterinárias foram obtidos 135 laudos de aspirados de medula óssea, 116 cães e 19 gatos, com idade média de 5,22 ± 3 anos, 53% eram do sexo masculino; A indicação mais frequente foi anemia persistente isolada ou acompanhada de outra alteração. Os itens com menor adesão na notificação dos resultados foram locais da punção (91,9%), dados clínicos relevantes (85,2%) e avaliação morfológica por linha (52,6%). 27,4% dos laudos foram excluídos por motivos associados à qualidade da amostra. O diagnóstico mais comum em cães foi hipoplasia (36,1%) e em gatos neoplasia (40,0%); A hiperplasia e a neoplasia eritróide foram mais comuns nos homens, enquanto a hipoplasia granulocítica foi mais comum nas mulheres. Conclusões: O estudo da medula óssea como ferramenta diagnóstica em cães e gatos tratados na Colômbia é raro. Foi encontrada uma percentagem significativa de amostras que não atendiam aos critérios de qualidade e baixa adesão às diretrizes para reporte de resultados.

|Resumo
= 25 veces | PDF (ENGLISH)
= 11 veces|

Downloads

Não há dados estatísticos.

Biografia do Autor

Ingrid J Roldán-Carvajal, Universidad de Antioquia

Grupo de Investigación HEMO, Escuela de Microbiología, Universidad de Antioquia. Medellín, Colombia

David Alzate-Velásquez, Clínica Veterinaria Caninos y Felinos

Clínica Veterinaria Caninos y Felinos. Medellín, Colombia

Julián D Muñoz-Duque, Universidad de Antioquia

Grupo de Investigación en Patobiología QUIRÓN, Facultad de Ciencias Agrarias, Universidad de Antioquia. Medellín, Colombia

Andrés F Mesa-Oquendo, Universidad CES

Universidad CES, Medellín, Colombia

Jorge E Salazar-Flórez, Fundación Universitaria San Martín

Fundación Universitaria San Martín, Sede Sabaneta, Colombia

Patricia E Jaramillo-Arbeláez, Universidad de Antioquia

Grupo de Investigación HEMO, Escuela de Microbiología, Universidad de Antioquia. Medellín, Colombia

Referências

Abella-Bourgès N, Trumel C, Chabanne L, Diquélou A. Myélogramme et biopsie de moelle osseuse. EMC - Vétérinaire 2005; 2(2): 74-95. https://doi.org/10.1016/j.emcvet.2005.05.001

Bonilla-Aldana DK, Gutiérrez-Grajales EJ, Osorio-Navia D, Chacón-Peña M, Trejos-Mendoza AE, Pérez-Vargas S, Valencia-Mejía L, Marín-Arboleda LF, Martínez-Hidalgo JP, Reina-Mora MA, González-Colonia LV, Cardona-Ospina JA, Jiménez-Posada EV, Diaz-Guio DA, Salazar JC, Sierra M, Muñoz-Lara F, Zambrano LI, Ramírez-Vallejo E, Rodríguez-Morales AJ. Haematological Alterations Associated with Selected Vector-Borne Infections and Exposure in Dogs from Pereira, Risaralda, Colombia. Animals 2022; 12(24): 3460-3475. https://doi.org/10.3390/ani12243460

Campbell MW, Hess PR, Williams LE. Chronic lymphocytic leukaemia in the cat: 18 cases (2000-2010). Vet Comp Oncol 2013; 11(4): 256-264. https://doi.org/10.1111/j.1476-5829.2011.00315.x

Chervier C, Cadoré JL, Rodriguez-Piñeiro MI, Deputte BL, Chabanne L. Causes of anaemia other than acute blood loss and their clinical significance in dogs. J Small Anim Pract 2012; 53(4): 223-227. https://doi.org/10.1111/j.1748-5827.2011.01191.x

Comazzi S, Avery PR, Garden OA, Riondato F, Rütgen B, Vernau W. European canine lymphoma network consensus recommendations for reporting flow cytometry in canine hematopoietic neoplasms. Cytometry Part B 2017; 92(5): 411-419. https://doi.org/10.1002/cyto.b.21382

Cowell RL, Valenciano AC, Diagnóstico citológico y hematológico del perro y el gato. España. Elsevier 2023;5th ed.

Creevy KE, Grady J, Little SE, Moore GE, Strickler BG, Thompson S, Webb JA. 2019 AAHA Canine Life Stage Guidelines. J Am Anim Hosp Assoc 2019; 55(6): 267-290. https://doi.org/10.5326/jaaha-ms-6999

Evans SJM. Flow Cytometry in Veterinary Practice. Vet Clin North Am Small Anim Pract 2023; 53(1): 89-100. https://doi.org/10.1016/j.cvsm.2022.07.008

Gilroy C, Forzán M, Drew A, Vernau W. Eosinophilia in a cat with acute leukemia. Can Vet J 2011; 52(9): 1004-1008. PMCID: PMC3157058

Girardi AF, Campos AN, Pescador CA, Almeida AD, Mendonça AJ, Nakazato L, Oliveira AC, Sousa VR. Quantitative analysis of bone marrow in pancytopenic dogs. Semina-ciencias Agrarias 2017; 38: 3639-3646. https://doi.org/10.5433/1679-0359.2017v38n6p3639

Grimes CN, Fry MM. Nonregenerative Anemia: Mechanisms of Decreased or Ineffective Erythropoiesis. Veterinary Pathology 2015; 52(2): 298-311. https://doi.org/10.1177/0300985814529315

Grindem CB, Neel JA, Juopperi TA. Cytology of bone marrow. Vet Clin North Am Small Anim Pract 2002; 32(6): 1313-1374. https://doi.org/10.1016/s0195-5616(02)00052-9

Grzelak AK, Fry MM. Anemia of Inflammatory, Neoplastic, Renal, and Endocrine Diseases. In: Brooks MB, Harr KE, Seelig DM, Wardrop KJ, Weiss DJ, editors. Schalm's Veterinary Hematology 7th ed. Nueva Jersey: Wiley-Blackwell. 2022; p. 313-317. https://doi.org/https://doi.org/10.1002/9781119500537.ch39

Haines JM, Mackin A, Day MJ. Immune-Mediated Anemia in the Dog. In: Brooks MB, Harr KE, Seelig DM, Wardrop KJ, Weiss DJ, editors. Schalm's Veterinary Hematology 7th ed. Nueva Jersey: Wiley-Blackwell 2022; p. 278-291. https://doi.org/10.1002/9781119500537.ch35

Hawkins R. Managing the pre- and post-analytical phases of the total testing process. Ann Lab Med 2012; 32(1): 5-16. https://doi.org/10.3343/alm.2012.32.1.5

Javinsky E. Hematology and Immune-Related Disorders. In: Little SE, editor. The Cat: Clinical Medicine and Management 2nd ed. Georgia: Elsevier Saunders 2012; p. 643-703. https://doi.org/10.1016/B978-1-4377-0660-4.00025-9

Lee SH, Erber WN, Porwit A, Tomonaga, M, Peterson LC. ICSH guidelines for the standardization of bone marrow specimens and reports. Int J Lab Hematol 2008; 30(5): 349-364. https://doi.org/10.1111/j.1751-553X.2008.01100.x

Messick JB. A Primer for the Evaluation of Bone Marrow. Vet Clin North Am Small Anim Pract 2023; 53(1): 241-263. https://doi.org/10.1016/j.cvsm.2022.08.002

Ministerio de Salud y Protección Social. Cobertura Vacunación antirrábica de perros y gatos por departamento y municipio. Colombia: biblioteca digital. 2022. https://www.minsalud.gov.co/BibliotecaDigital/vacunacion-antirrabica-perros-gatos2022

Molina V. Prevalence of the Feline Leukemia Virus (FeLV) in Southern Valle de Aburrá, Colombia. Rev Med Vet 2020; 40: 9-16. https://doi.org/10.19052/mv.vol1.iss40.2

Moore C, Krishnan K. Bone Marrow Failure. StatPearls [Internet] 2023. https://www.ncbi.nlm.nih.gov/books/NBK459249/

Mylonakis M, Hatzis A. Practical bone marrow cytology in the dog and cat. J Hellenic Vet Med Soc 2014; 65(3): 181-196. https://doi.org/10.12681/jhvms.15534

Newman A, Stokol T. Immune-Mediated Anemia in the Cat. In: Brooks MB, Harr KE, Seelig DM, Wardrop KJ, Weiss DJ, editors. Schalm's Veterinary Hematology 7th ed. Nueva Jersey: Wiley-Blackwell 2022; p. 292-299. https://doi.org/10.1002/9781119500537.ch36

Orazi A, O’Malley DP, Arber DA. The hyperplasias. In Orazi A, Arber DA, O'Malley DP, editors. Illustrated Pathology of the Bone Marrow 1st ed. Cambridge: Cambridge University Press 2006; p. 31-38. https://doi.org/10.1017/CBO9780511543531

Ortega C, Valencia AC, Duque-Valencia J, Ruiz-Saenz J. Prevalence and Genomic Diversity of Feline Leukemia Virus in Privately Owned and Shelter Cats in Aburrá Valley, Colombia. Viruses 2020; 12(4); 464-477. https://doi.org/10.3390/v12040464

Patel RT, Caceres A, French AF, McManus PM. Multiple myeloma in 16 cats: a retrospective study. Vet Clin Pathol 2005; 34(4): 341-352. https://doi.org/https://doi.org/10.1111/j.1939-165X.2005.tb00059.x

Pinello K, Pires I, Castro AF, Carvalho PT, Santos A, de Matos A, Queiroga F, Canadas-Sousa A, Dias-Pereira P, Catarino J, Faísca P, Branco S, Lopes C, Marcos F, Peleteiro MC, Pissarra H, Ruivo P, Magalhães R, Severo M, Niza-Ribeiro J. Cross Species Analysis and Comparison of Tumors in Dogs and Cats, by Age, Sex, Topography and Main Morphologies. Data from Vet-OncoNet. Vet. Sci 2022; 9(4): 167-185. https://doi.org/10.3390/vetsci9040167

Posada O S, Gomez OL, Rosero NR. Application of the logistic model to describe the growth curve in dogs of different breeds. Rev MVZ Córdoba 2014; 19: 4015-4022. https://doi.org/10.21897/rmvz.121

Rafalko JM, Kruglyak KM, McCleary-Wheeler AL, Goyal V, Phelps-Dunn A, Wong LK, Warren CD, Brandstetter G, Rosentel MC, DiMarzio L, McLennan LM, O'Kell AL, Cohen TA, Grosu DS, Chibuk J, Tsui DWY, Chorny I, Flory A. Age at cancer diagnosis by breed, weight, sex, and cancer type in a cohort of more than 3,000 dogs: Determining the optimal age to initiate cancer screening in canine patients. PLoS One 2023; 18(2): e0280795. https://doi.org/10.1371/journal.pone.0280795

Raskin RE, Messick JB. Bone marrow cytologic and histologic biopsies: indications, technique, and evaluation. Vet Clin North Am Small Anim Pract 2012; 42(1): 23-42. https://doi.org/10.1016/j.cvsm.2011.10.001

Riley RS, Gandhi P, Harley SE, Garcia P, Dalton JB, Chesney A. A Synoptic Reporting System to Monitor Bone Marrow Aspirate and Biopsy Quality. J Pathol Inform 2021; 12: 23-29. https://doi.org/10.4103/jpi.jpi_53_20

Ritt MG. Epidemiology of Hematopoietic Neoplasia. In: Brooks MB, Harr KE, Seelig DM, Wardrop KJ, Weiss DJ, editors. Schalm's Veterinary Hematology 7th ed. Nueva Jersey: Wiley-Blackwell; 2022. p. 457-462. https://doi.org/10.1002/9781119500537.ch58

Rout ED, Burnett RC, Yoshimoto JA, Avery PR, Avery AC. Assessment of immunoglobulin heavy chain, immunoglobulin light chain, and T-cell receptor clonality testing in the diagnosis of feline lymphoid neoplasia. Vet Clin Pathol 2019; 48(S1): 45-58. https://doi.org/https://doi.org/10.1111/vcp.12767

Rütgen BC, Bouschor J. Classification and General Features of Lymphoma and Leukemia. In: Brooks MB, Harr KE, Seelig DM, Wardrop KJ, Weiss DJ, editors. Schalm's Veterinary Hematology 7th ed. Nueva Jersey: Wiley-Blackwell; 2022;p. 528-537. https://doi.org/10.1002/9781119500537.ch65

Santisteban RR, Muñoz-Rodríguez LC, Díaz Nieto J, Pachón-Londoño V, Curiel-Peña J. Seroprevalencia del virus de inmunodeficiencia felina (VIF) y el virus de la leucemia felina (ViLeF) en gatos del centro de Risaralda, Colombia. Rev Inv Vet Perú 2021; 32(3): e18901. https://doi.org/10.15381/rivep.v32i3.18901

Sciacovelli L, Aita A, Padoan A, Pelloso M, Antonelli G, Piva E, Chiozza ML, Plebani M. Performance criteria and quality indicators for the post-analytical phase. Clin Chem Lab Med 2016; 54(7): 1169-1176. https://doi.org/10.1515/cclm-2015-0897

Sever C, Abbott CL, de Baca ME, Khoury JD, Perkins SL, Reichard KK, Taylor A, Terebelo HR, Colasacco C, Rumble RB, Thomas NE. Bone Marrow Synoptic Reporting for Hematologic Neoplasms: Guideline From the College of American Pathologists Pathology and Laboratory Quality Center. Arch Pathol Lab Med 2016; 140(9): 932-949. https://doi.org/10.5858/arpa.2015-0450-SA

Siddon AJ, Kroft SH. The Lab as a Driver of Quality in the Preanalytical Realm: The Case of Technologist-Assisted Bone Marrow Biopsies. Am J Clin Pathol 2021; 157(4): 480-481. https://doi.org/10.1093/ajcp/aqab180

Sontas HB, Dokuzeylu B, Turna O, Ekici H. Estrogen-induced myelotoxicity in dogs: A review. Can Vet J 2009; 50(10): 1054-1058. PMCID: PMC2748286

Stacy NI, Harvey JW. Bone marrow aspirate evaluation. Vet Clin North Am Small Anim Pract 2017; 47(1): 31-52. https://doi.org/10.1016/j.cvsm.2016.07.003

Tommasi ASD, Baneth G, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Otranto D, Caprariis D. Anaplasma platys in Bone Marrow Megakaryocytes of Young Dogs. J Clin Microbiol 2014; 52(6): 2231-2234. https://doi.org/doi:10.1128/jcm.00395-14

Turinelli V, Gavazza A, Stock G, Fournel-Fleury C. Canine bone marrow cytological examination, classification, and reference values: A retrospective study of 295 cases. Res Vet Sci 2015; 103: 224-230. https://doi.org/10.1016/j.rvsc.2015.10.008

Turinelli V, Gavazza A. Retrospective study of 152 feline cytological bone marrow examinations: preliminary classification and ranges. J Feline Med Surg 2018; 20(12): 1158-1168. https://doi.org/10.1177/1098612x18757602

The Royal College of Pathologists of Australasia. Bone marrow specimen (aspirate and trephine biopsy) structured reporting protocol. 1st ed. RCPA. 2014. ISBN: 978-1-74187-964-3

Trejo-Ayala RA, Luna-Pérez M, Gutiérrez-Romero M, Collazo-Jaloma J, Cedillo-Pérez MC, Ramos-Peñafiel CO. Bone marrow aspiration and biopsy. Technique and considerations. Rev Med Hosp Gen Méx 2015; 78(4): 196-201. https://doi.org/10.1016/j.hgmx.2015.06.006

Weiss DJ, Aird B. Cytologic Evaluation of Primary and Secondary Myelodysplastic Syndromes in the Dog. Vet Clin Pathol 2001; 30(2): 67-75. https://doi.org/https://doi.org/10.1111/j.1939-165X.2001.tb00261.x

Weiss DJ. A retrospective study of the incidence and classification of bone marrow disorder in cats (1996–2004). Comp Clin Path 2006a; 14: 179-185. http://dx.doi.org/10.1007/s00580-005-0575-1

Weiss DJ. A retrospective study of the incidence and the classification of bone marrow disorders in the dog at a veterinary teaching hospital (1996–2004). J Vet Intern 2006b; 20(4): 955-961. https://doi.org/10.1111/j.1939-1676.2006.tb01811.x

Weiss DJ. Blood and Bone Marrow Toxicity Induced by Drugs, Heavy Metals, Chemicals, and Toxic Plants. In: Brooks MB, Harr KE, Seelig DM, Wardrop KJ, Weiss DJ, editors. Schalm's Veterinary Hematology 7th ed. Nueva Jersey: Wiley-Blackwell 2022; p. 122-132. https://doi.org/10.1002/9781119500537.ch15

Woods GA, Simpson M, Boag A, Paris J, Piccinelli C, Breheny C. Complications associated with bone marrow sampling in dogs and cats. J Small Anim Pract 2021; 62(3): 209-215. https://doi.org/10.1111/jsap.13274

Downloads

Publicado

2024-12-11

Como Citar

Roldán-Carvajal, I. J., Alzate-Velásquez, D., Muñoz-Duque, J. D., Mesa-Oquendo, A. F., Salazar-Flórez, J. E., & Jaramillo-Arbeláez, P. E. (2024). Caracterização de laudos de aspirados de medula óssea em cães e gatos: estudo retrospectivo. Revista Colombiana De Ciencias Pecuarias. https://doi.org/10.17533/udea.rccp.v38n2a9

Edição

Seção

Accepted manuscripts