MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO
DOI:
https://doi.org/10.17533/udea.vitae.508Keywords:
Carrageenan matrices, eudragit RLPO matrices, chlorpheniramine maleate, bioadhesion, sustained release, controlled release, mucoadhesive.Abstract
The objective of this research is a bioadhesive two layers controlled release tablets. The drug
release and the physical properties of tablet formulations using two polymers (Carrageenan 934
and Eudragit RL PO) at three levels and at a combination of different ratios of the two polymers
were evaluated. Formulation containing 40% total polymer level and a ratio of 1 Carrageenan to
1 Eudragit RLPO was the best formulationa. This formulation was tested in different dissolution
medium and at different rotational speed. The drug release was 96.3% in phosphate buffer pH
7.4; 59.1% in 0.1 N HCl and 46.4% in distilled water.
This study demonstrates the significance of the combination of two polymers for obtaining
controlled release bioadhesive matrix and enhancing the characteristic of each polymer.
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