MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO

Authors

  • Gloria RUÍZ
  • Evone S. GHALY

Keywords:

Carrageenan matrices, eudragit RLPO matrices, chlorpheniramine maleate, bioadhesion, sustained release, controlled release, mucoadhesive.

Abstract


The objective of this research is a bioadhesive two layers controlled release tablets. The drug

release and the physical properties of tablet formulations using two polymers (Carrageenan 934

and Eudragit RL PO) at three levels and at a combination of different ratios of the two polymers

were evaluated. Formulation containing 40% total polymer level and a ratio of 1 Carrageenan to

1 Eudragit RLPO was the best formulationa. This formulation was tested in different dissolution

medium and at different rotational speed. The drug release was 96.3% in phosphate buffer pH

7.4; 59.1% in 0.1 N HCl and 46.4% in distilled water.

This study demonstrates the significance of the combination of two polymers for obtaining

controlled release bioadhesive matrix and enhancing the characteristic of each polymer.

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Published

2009-02-02

How to Cite

RUÍZ, G., & GHALY, E. S. (2009). MUCOADHESIVE DELIVERY SYSTEMS USING CARRAGEENAN AND EUDRAGIT RLPO. Vitae, 13(1). Retrieved from https://revistas.udea.edu.co/index.php/vitae/article/view/508

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