Biomarcadores para la evaluación de riesgo en la salud humana

Sandra S. Arango V.

doi:10.17533/udea.rfnsp.9607

Authors

Sandra S. Arango V. Metropolitan Technological Institute

DOI:

https://doi.org/10.17533/udea.rfnsp.9607

Keywords:

biomarkers, occupational health, toxicology, carcinogenesis

Abstract

In the field of human health, the development, validation, and use of biomarkers as information tools to assess risk factors associated with exposure to environmental agents increases daily. This is a result of the need to understand the adverse effects of the various work environments and lifestyles. A biomarker is an event that takes place in a biological system and is understood as an indicator of health status, life expectancy, or disease risk. Biomarkers usually fall within the following categories: exposure, effect, and susceptibility biomarkers. This review will discuss their importance in understanding different aspects of diseases such as diagnosis, treatment, prevention, disease progression, response to therapy, and their application in toxicological experimental evaluation for the development of drugs or pesticides. Furthermore, their contribution to the development of different fields of study such as toxicology, occupational health, and carcinogenesis shall also be discussed.

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Author Biography

Sandra S. Arango V., Metropolitan Technological Institute

Master in biotechnology, biologist. Professor, Metropolitan Technological Institute, Medellín, Colombia.

References

(1). Ilizaliturri C, González D, Pelallo N, Domínguez G, Mejía J, Torres A, et al. Revisión de las metodologías sobre evaluación de riesgos en salud para el estudio de comunidades vulnerables en América Latina. Interciencia. 2009; 34(10): 710-717.

(2). Lock EA, Bonventre JV. Biomarkers in translation; past, present and future. Toxicology 2008; 245(3): 163-166. DOI: https://doi.org/10.1016/j.tox.2007.12.004

(3). Llynin A, Belkowski S, Plata C. Biomarkers discovery and validation: technologies and integrative approaches. trends in Biote-chnology. 2004; 8(4): 411-416 DOI: https://doi.org/10.1016/j.tibtech.2004.06.005

(4). Mayeux R. Biomarkers: potential uses and limitations. The jour-nal of the American Society for Experimental NeuroTherapeutics. 2004; 2(1): 182-188 DOI: https://doi.org/10.1007/BF03206601

(5). Schulte PA. The contributions of genetic and genomic to occupational safety and health. Occup. Environ. Med. 2007; 64(1): 717-718. DOI: https://doi.org/10.1136/oem.2006.030619

(6). Poste G. Bring on the biomarkers. Nature. 2011; 469(1): 156-157 DOI: https://doi.org/10.1038/469156a

(7). Albertini RJ. Biomarker responses in human populations: towards a worldwide map. Mutat. Res. 1999; 428(1-2): 217-226. DOI: https://doi.org/10.1016/S1383-5742(99)00049-6

(8). Vainio H. Review: Use of biomarkers in risk assessment. Int J Hyg Environ Health. 2001; 204(2-3): 91-102. DOI: https://doi.org/10.1078/1438-4639-00088

(9). Van den Brand P, Voorrips L, Hertz I, Shuker D, Boeing H, Speijers G, et al. The contribution of epidemiology. Food Chem. Toxi-col. 2002; 40(1): 387-424. DOI: https://doi.org/10.1016/S0278-6915(01)00114-4

(10). Schulte PA, Hauser JE. The use of biomarkers in occupational health research, practice, and policy. Toxicology Letters. 2011 Mar. DOI: https://doi.org/10.1016/j.toxlet.2011.03.027

(11). Atkinson AJ, Colburn WA, DeGruttola VG, DeMets DL, Dow-ning GJ, Hoth DF, et al. Biomarkers and surrogate endopoints: preferred definitions and conceptual framework. Clin. Pharmacol. Therap. 2000; 69(1): 89-95. DOI: https://doi.org/10.1067/mcp.2001.113989

(12). Owen R, Depledge M, Hagger J, Jones M, Galloway T. Biomarkers and environmental risk assessment: guiding principles from the human health field. Marine Pollution Bulletin. 2008; 56(1): 613-619. DOI: https://doi.org/10.1016/j.marpolbul.2008.01.022

(13). Tambor V, Fucíková A, Lenco J, Kacerovský M, Rehácek V, Stu-lík J, et al. Application of proteomics in biomarker discovery: a primer for the clinician. Physiol Res. 2010; 59(4): 471-497. DOI: https://doi.org/10.33549/physiolres.931758

(14). Department of Health and Human Services, U.S. Food and Drug Administration. The Critical Path Initiative: Transforming the Way FDA-Regulated Products are Developed, Evaluated, Manu-factured, and Used 2009. Washington DC: fda; 2009.

(15). Goodsaid FM, Frueh FW. Questions and answers about the pilot process for biomarkers qualification at the FDA. Drug Discovery Today: Technologies. 2007; 4(1): 9-11. DOI: https://doi.org/10.1016/j.ddtec.2007.10.005

(16). Bonassi S, Au WW. Biomarkers in molecular epidemiology studies for health risk prediction. Mutation Research. 2002; 511(1): 73-86. DOI: https://doi.org/10.1016/S1383-5742(02)00003-0

(17). World Health Organization. Biomarkers and risk assessment: con-cepts and principles Environmental health criteria; N° 155I CPS 1993 [internet]. Geneva: who/ipcs; 1993 [acceso 15 de junio de 2010]. Disponible en: http://www.inchem.org/documents/ehc/ehc/ehc155.htm

(18). Lee JW, Devanarayan V, Barrett YC, Weiner R, Allinson J, Foun-tain S, et al. Fit-for-purpose method development and validation for successful biomarker measurement. Pharm. Res. 2006; 23(2): 312-328. DOI: https://doi.org/10.1007/s11095-005-9045-3

(19). Goodsaid FM, Frueh FW, Mattes W. “Strategic paths for biomar-ker qualification”. Toxicology. 2008; 245(3): 219-223. DOI: https://doi.org/10.1016/j.tox.2007.12.023

(20). Schulte P. Opportunities for the development and use of biomar-kers. Toxicol Lett. 1995; 77(1-3): 25-29. DOI: https://doi.org/10.1016/0378-4274(95)03267-3

(21). Knudsen LE, Hansen AM. Biomarkers of intermediate endpo-ints in environmental and occupational health. Int J Hyg Environ Health. 2007; 210(3-4): 461-470. DOI: https://doi.org/10.1016/j.ijheh.2007.01.015

(22). Rodríguez E, García D, Carabias R. Development and validation of a method for the detection and confirmation of biomarkers of exposure in human urine b y means of restricted access material-liquid chromatography–tandem mass spectrometry. Journal of Chromatography A. 2010; 1217(1): 40-48. DOI: https://doi.org/10.1016/j.chroma.2009.11.002

(23). Shuker D. The enemy at the gates? DNA adducts as biomarkers of exposure to exogenous and endogenous genotoxic agents. Toxico-logy Letters. 2002; 134: 51-56. DOI: https://doi.org/10.1016/S0378-4274(02)00162-5

(24). Funk WE, He L, Iavarone AT, Williams ER, Riby J, Rappaport SM. Biochemistry Enrichment of cysteinyl adducts of human serum albumin. Analytical Biochemistry. 2010; 400(1): 61-68. DOI: https://doi.org/10.1016/j.ab.2010.01.006

(25). Richter E, Branner B. Biomonitoring of exposure to aromatic ami-nes: haemoglobinadducts in humans. Journal of Chromatography B. 2002; 778(1-2): 49-62. DOI: https://doi.org/10.1016/S0378-4347(01)00466-2

(26). Shankar A, Mitchell P, Rochtchina E, Wang J. The association between circulating white blood cell count, triglyceride level and cardiovascular and all cause mortality: population-based cohort study. Atherosclerosis. 2007; 192(1): 177-183. DOI: https://doi.org/10.1016/j.atherosclerosis.2006.04.029

(27). Maiese K, Chong Z, Hou J, Shang Y. Oxidative stress: Biomar-kers and novel therapeutic pathways. Experimental Gerontology. 2010; 45(3): 217-234. DOI: https://doi.org/10.1016/j.exger.2010.01.004

(28). Lieggi NT, Edvardsson A, O’Brien PJ. Translation of novel anticancer cytotoxicity biomarkers detected with high content analysis from an in vitro predictive model to an in vivo cell model. Veterinary Science Toxicology in Vitro. 2010; 24(8): 2063-2071. DOI: https://doi.org/10.1016/j.tiv.2010.07.014

(29). Greystokea A, Hughesa A, Ransona M, Divea C, Cummingsa J, Warda T. Serum biomarkers of apoptosis. European Journal of Cancer Supplements. 2007; 5(5): 115-127. DOI: https://doi.org/10.1016/S1359-6349(07)70032-0

(30). Whiteaker JR, Zhao L, Zhang HY, Feng L, Piening BD, Ander-son L, et al. Antibody-based enrichment of peptides on magnetic beads for mass-spectrometry-based quantification of serum bio-markers. AnalyticalBiochemistry. 2007; 362(1): 44-54. DOI: https://doi.org/10.1016/j.ab.2006.12.023

(31). Anderson JE, Hansen LL, Mooren FC, Post M, Hug H, Zuse A, Los M. Methods and biomarkers for the diagnosis and progno-sis of cancer and other diseases: Towards personalized medicine. Drug Resistance. 2006; 9(4-5): 198-210. DOI: https://doi.org/10.1016/j.drup.2006.08.001

(32). Norppa H. Cytogenetic biomarkers and genetic polymorphisms. Toxicology Letters. 2004; 149(1-3): 309-334. DOI: https://doi.org/10.1016/j.toxlet.2003.12.042

(33). Knudsen LE, Loft SH, Autrup H. Risk assessment: the importan-ce of genetic polymorphisms in man. Mutation Research. 2001; 482(1-2): 83-88. DOI: https://doi.org/10.1016/S0027-5107(01)00213-5

(34). Timbrell JA. Biomarker in toxicology. Toxicology. 1998; 129(1-7): 1-12. DOI: https://doi.org/10.1016/S0300-483X(98)00058-4

(35). Gil F. El papel de los biomarcadores en Toxicologíaa humana. Re-vista de Toxicología. 2000; 17(1): 19-26.

(36). Eason C, O’Halloran K. Biomarkers in toxicology versus ecological risk assessment. Toxicology. 2002; 181-182: 517-521. DOI: https://doi.org/10.1016/S0300-483X(02)00472-9

(37). Vasseur P, Cossu C. Biomarkers and community indices as complementary tools for environmental safety. Environ. Int. 2003; 28(8): 711-717. DOI: https://doi.org/10.1016/S0160-4120(02)00116-2

(38). Grandjen S, Bonassi S. Linking toxicology to epidemiology: biomarkers and new technologies-special issue overview. Mutat. Res. 2005; 592(1): 3-5. DOI: https://doi.org/10.1016/j.mrfmmm.2005.05.007

(39). Bakhtiar R. Biomarkers in drug discovery and development. Journal of Pharmacological and Toxicological Methods. 2008; (57)2: 85-91. DOI: https://doi.org/10.1016/j.vascn.2007.10.002

(40). Swenberg JA, Fryar E, Jeong Y, Boysen G, Starr T, Walker VE, Albertini RJ. Biomarkers in Toxicology and Risk Assessment: In-forming Critical Dose-Response Relationships. Chem Res Toxi-col. 2008; 21(1): 253-265. DOI: https://doi.org/10.1021/tx700408t

(41). Moore TJ, Cohen MR, Furger CD. Serious adverse drug events reported to the Food and Drug Administration, 1998-2005. Arch. Intern. Med. 2007; 167(16): 1752-1759. DOI: https://doi.org/10.1001/archinte.167.16.1752

(42). Mendrick DL. Genomic and genetic biomarkers of toxicity. Toxi-cology. 2008; 245(3): 175-181. DOI: https://doi.org/10.1016/j.tox.2007.11.013

(43). Beals JK. “FDA Releases List of Genomic Biomarkers Predictive of Drug Interactions” [internet]. New York: Medscape Medical News; 2008. [acceso 12 de Julio de 2010]. Disponible en: http://www.medscape.com/viewarticle/578464.

(44). Mateuca R, Lombaert N, Aka P, Decordier I, Kirsch M. Chromo-somal changes: induction, detection methods and applicability in human biomonitoring. Biochimie. 2006; 88(1): 1515-1531. DOI: https://doi.org/10.1016/j.biochi.2006.07.004

(45). Smolders R, Bartonova A, Boogaard PJ, Dusinska M, Koppen G, Merlo F, et al. The use of biomarkers for risk assessment: re-porting from the INTARESE/ENVIRISK Workshop in Prague. International journal of hygiene and environmental health. 2010; 213(5): 395-400. DOI: https://doi.org/10.1016/j.ijheh.2010.05.006

(46). Manno M, Viau C, Cocker J, Colosio C, Lowrye L, Muttif A, Nor-dbergg M, Wangh S. Biomonitoring for occupational health risk assessment (BOHRA). Toxicol Lett. 2010; 192: 3-16. DOI: https://doi.org/10.1016/j.toxlet.2009.05.001

(47). Shvedova A, Kisin ER, Mercer R, Murray AR, Johnson VJ,Pota-povich A, et al. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbón nanotubes in mice. Am. J. Phy-siol. Lung. Cell. Mol. 2005; 289(5): L698-708. DOI: https://doi.org/10.1152/ajplung.00084.2005

(48). Schulte P, Howard J. Genetic Susceptibility and the Setting of Occupational Health Standards. Annu. Rev. Public Health. 2011; 32(1): 149-159. DOI: https://doi.org/10.1146/annurev-publhealth-031210-101144

(49). American Conference of Governmental Industrial Hygienists. Annual Reports of the Committee on TLVs and BEIS for the tear 2009. Cincinnati: acgih; 2010.

(50). German Research Foundation. List of MAK and BAT Values: Maximun Concetrationes and Biological tolerance Values at the Workplace. California: dfg; 2009.

(51). Occupational Safety and Health Administration. Blood lead Labo-ratories Program Descriptions and Background. Salt Lake Techni-cal Center (SLCT). U.S Department of labor, Occupational safety and Health Administration. Washington D.C: osha; 2005.

(52). National Institute for Occupational Safety and Health preventing occupational. nioshList of Antineoplastic and Other Hazardous Drugs in Healthcare settings 2010. Cincinnati: niosh; 2010.

(53). Plant N. Can systems toxicology identify commom biomarker of non-genotoxic carcinogénesis? Toxicology. 2008; 254(3): 164-169. DOI: https://doi.org/10.1016/j.tox.2008.07.001

(54). Vineis P. Use of biomarkers in epidemiology: the example o me-tabolic susceptibility to cancer. Toxicol Lett. 1995; 77(1-3): 163-168. DOI: https://doi.org/10.1016/0378-4274(95)03286-X

(55). Kyrtopoulos SA. Biomarkers in environmental carcinogenesis research: Striving for a new momentum. Toxicology Lett. 2006; 162(1): 3-15. DOI: https://doi.org/10.1016/j.toxlet.2005.10.010

(56). Albertini RJ, Anderson D, Douglas GR, Hagmar L, Hemminki K, Merlo F, et al. IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. Mutat Res. 2000; 463(1): 111-172. DOI: https://doi.org/10.1016/S1383-5742(00)00049-1

(57). Fenech M. Biomarkers of genetic damage for cancer epidemiolo-gy. Toxicology. 2002; 181-182: 411-416. DOI: https://doi.org/10.1016/S0300-483X(02)00480-8

(58). Hick AS, Paczkowski M, Gadano AB, Carballo MA. Biomarca-dores de Genotoxicidad en Individuos Expuestos al Arsénico. Lat. Am. J. Pharm. 2007; 26(5): 691-699.

(59). Jimeno A, Hidalgo M. Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pan-creatic cancer. Mol Cancer Ther. 2006; 5(4): 787-796. DOI: https://doi.org/10.1158/1535-7163.MCT-06-0005

(60). Hsueh YM, Cheng GS, Wu M, Yu HS, Kuo TL, Chen CJ. Multiple risk factors associated with arsenic-induced skin cancer: effects of chronic liver disease and malnutritional status. Br J Cancer. 1995; 71(1): 109-114. DOI: https://doi.org/10.1038/bjc.1995.22

(61). Dopp E, Hartmann L, Florea A, Recklinghausen V, Pieper R, Shokouhi B, et al. Uptake of inorganic and organic derivatives of arsenic associated with induced cytotoxic and genotoxic effects in Chinese hamster ovary (CHO) cells. Toxicol Appl Pharmacol. 2004; 201(2): 156-165. DOI: https://doi.org/10.1016/j.taap.2004.05.017

(62). Trossero C, Caffarena G, Hure E, Rizzotto M. Detección de Mutagenicidad en Compuestos N-Nitrosocon el Test de Ames Acta Farm. Bonaerense.2006; 25(1): 139-144.

(63). Tainsky MA. Genomic and proteomic biomarkers for cancer: a multitude of opportunities. Biochim Biophys Acta 2009 (2):176-193. DOI: https://doi.org/10.1016/j.bbcan.2009.04.004

(64). Kuramitsu Y, Nakamura K. Proteomic analysis of cancer tissues: shedding light on carcinogenesis and possible biomarkers. Proteo-mics 2006; 6:5650–5661. DOI: https://doi.org/10.1002/pmic.200600218

(65). Narayan A, Mathur R, Farooque A, Verma A; Dwarakanath B.S Cancer biomarkers - current perspectives. The Indian journal of medical research 2010; 132: 129-149.