Mecanismos de activación de las células T asesinas naturales invariantes (iNKT)

Autores/as

  • Andrés Baena Universidad de Antioquia
  • Lina Gómez-Giraldo Universidad de Antioquia
  • Leandro J Carreño Universidad de Chile

DOI:

https://doi.org/10.17533/udea.iatreia.v29n1a05

Palabras clave:

α-galactosilceramida, células inkt, CD1d, glicolípidos, presentación antigénica, TCR

Resumen


Aunque se ha logrado un conocimiento amplio acerca de las células T asesinas naturales (iNKT), aún no existe consenso sobre sus mecanismos de activación. Dichas células reconocen diferentes antígenos glicolipídicos presentados por medio de la molécula CD1d, los cuales pueden ser endógenos, exógenos derivados de organismos como bacterias y sintéticos desarrollados para aplicaciones clínicas. Existe mucho interés en entender cómo estas distintas variantes glicolipídicas inducen diferentes tipos de polarización, pero ha sido muy difícil llegar a un consenso, debido a que la respuesta depende de varios factores como la naturaleza, la internalización y el procesamiento de los glicolípidos. Además, la activación de las células iNKT la determinan el tipo y estado de activación de la célula presentadora de antígeno, las moléculas coestimuladoras, los mecanismos de transactivación y la localización de los complejos CD1d-glicolípido en distintas microrregiones de la membrana plasmática, como las balsas lipídicas. Esta revisión explora la evidencia sobre los factores que afectan la activación de las células iNKT con el fin de entender su potencial inmunomodulador. 

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Biografía del autor/a

Andrés Baena, Universidad de Antioquia

Grupo de Inmunología Celular e Inmunogenética, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.

Lina Gómez-Giraldo, Universidad de Antioquia

Grupo de Inmunología Celular e Inmunogenética, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.

Leandro J Carreño, Universidad de Chile

Instituto Milenio de Inmunología e Inmunoterapia, Programa Disciplinario de Inmunología, Facultad de Medicina, Universidad de Chile, Santiago, Chile. Departamento de Microbiología e Inmunología, Facultad de Medicina Albert Einstein. Nueva York, Estados Unidos.

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2015-11-17

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1.
Baena A, Gómez-Giraldo L, Carreño LJ. Mecanismos de activación de las células T asesinas naturales invariantes (iNKT). Iatreia [Internet]. 17 de noviembre de 2015 [citado 25 de junio de 2022];29(1):51-64. Disponible en: https://revistas.udea.edu.co/index.php/iatreia/article/view/21776

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