Bone angiosarcoma in the humerus of a pediatric patient, a whole diagnostic challenge: case report

Abstract

Angiosarcoma of the bone is a rare, aggressive and poor-prognosis malignancy, that is unusual in children. This entity preferentially affects the tubular bones, and can present as a solitary or multicentric lesion. We present the case of a 7-year-old girl, without medical surgical history, who  onsulted to the National Cancer Institute - Colombia, for presenting a tumor lesion that compromised the  entire humerus, destroying it and deforming the arm. To guide the diagnosis of the lesion, a detailed histopathological study and immunohistochemical markers were performed, which suggested a  alignant vascular neoplasm. Due to the extensive tumor involvement, the only therapeutic option was scapulothoracic disarticulation of the limb, followed by adjuvant management with a  hemotherapy protocol. During the chemotherapy cycles, the patient presented metastatic lesions in the lung, which were resected. At the moment, she is without tumor lesions and under close follow-up.